EFFECTS OF GRAPE SEED EXTRACT ON ISCHEMIA-REPERFUSION INDUCED INFARCT SIZE OF ISOLATED RAT HEARTS

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VAEZ H.; ZAHEDNEZHAD F.; SAMADZADEH MEHRABAN; NAJAFI MOSLEM; BABAEI HOSSEIN

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Seminar Paper

Paper Information

Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Year:2009 | Issue:19

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Title

EFFECTS OF GRAPE SEED EXTRACT ON ISCHEMIA-REPERFUSION INDUCED INFARCT SIZE OF ISOLATED RAT HEARTS

Author(s)

VAEZ H. | ZAHEDNEZHAD F. | SAMADZADEH MEHRABAN | NAJAFI MOSLEM | BABAEI HOSSEIN

Keywords

GRAPE SEED EXTRACT

ISCHEMIA-REPERFUSION

INFARCT SIZE

ISOLATED RAT HEARTS

Abstract

As no studies performed about pharmacologic effects of GRAPE SEED EXTRACT (GSE) on ischemia/reperfusion-induced injuries especially INFARCT SIZE, we performed this study to investigate effects of GSE on ISOLATED RAT HEARTS. Male SD rats were divided into four groups (n=8 in each group) and isolated hearts mounted on Langendorff apparatus under constant pressure and temperature. After stabilization (30 min), regional ischemia induced for 30 min followed by 120 min reperfusion. In the control group, the hearts were perfused with extract free Krebs-Henseleit (K/H) solution, while in the test groups; they were perfused 1, 10 and 100 mg/l of GSE enriched K/H solution from 15 min before ischemia to 120 min reperfusion. Then the hearts colored by evans blue and incubated by triphenyl tetrazolim chloride (TTZ). The area of infacted tissue was determined by computerized planimetry. The results show that perfusion of GSE produced significant reduction in INFARCT SIZE from 31±5% in control group to 12±3%, 16±6% (p<0.05) and 2±1% (p<0.01) in the test groups of GSE (1, 10 and 100 mg/l). The results can be attributed to the protective effects of proanthocyanidins to their ability to eliminatehydroxyl radicals. Also they may interact with intracellular calcium ions, leading to a reduction in reperfusion-induced calcium overload.

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APA: Copy

VAEZ, H., ZAHEDNEZHAD, F., SAMADZADEH, MEHRABAN, NAJAFI, MOSLEM, & BABAEI, HOSSEIN. (2009). EFFECTS OF GRAPE SEED EXTRACT ON ISCHEMIA-REPERFUSION INDUCED INFARCT SIZE OF ISOLATED RAT HEARTS. IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. SID. https://sid.ir/paper/904119/en

Vancouver: Copy

VAEZ H., ZAHEDNEZHAD F., SAMADZADEH MEHRABAN, NAJAFI MOSLEM, BABAEI HOSSEIN. EFFECTS OF GRAPE SEED EXTRACT ON ISCHEMIA-REPERFUSION INDUCED INFARCT SIZE OF ISOLATED RAT HEARTS. 2009. Available from: https://sid.ir/paper/904119/en

IEEE: Copy

H. VAEZ, F. ZAHEDNEZHAD, MEHRABAN SAMADZADEH, MOSLEM NAJAFI, and HOSSEIN BABAEI, “EFFECTS OF GRAPE SEED EXTRACT ON ISCHEMIA-REPERFUSION INDUCED INFARCT SIZE OF ISOLATED RAT HEARTS,” presented at the IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. 2009, [Online]. Available: https://sid.ir/paper/904119/en

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