STUDY OF THE ANTI-INFLAMMATORY EFFECTS OF SIMVASTATIN IN CARRAGEENAN INDUCED FOOTPAD EDEMA IN RATS

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ZIAEI M.; ANDALIB S.; GARJANI A.R.; ZAKHERI A.

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Seminar Paper

Paper Information

Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Year:2007 | Issue:18

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Title

STUDY OF THE ANTI-INFLAMMATORY EFFECTS OF SIMVASTATIN IN CARRAGEENAN INDUCED FOOTPAD EDEMA IN RATS

Author(s)

ZIAEI M. | ANDALIB S. | GARJANI A.R. | ZAKHERI A.

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Abstract

Inhibitors of 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase, such as Simvastatin, lower circulating cholesterol levels and prevent myocardial infarction. Several studies have shown an unexpected effect of HMG-CoA reductase inhibitors on inflammation. Here, we confirm that Simvastatin is anti-inflammatory by using a classic model of inflammation: Carrageenan-induced foot pad edema. Simvastatin administered with 1mg/kg, 5mg/kg, 10mg/kg doses orally to rats 20, 12, 6, 1 hour before carrageenan injection significantly reduced the extent of edema. Changes in foot pad volume instantly after injection up to 4th hour periodically measured. Simvastatin did not alter plasma lipids. Simvastatin with 5 mg/kg, 10 mg/kg has shown its anti-inflammatory effects in 2nd and 4th hours (P<0.001). In addition, Simvastatin with 1mg/kg, decrease foot pad volume in 4th hour. Every 3 used doses decrease foot pad volume in 4th hour equally. Histology of foot pad lesions showed that simvastatin alter the rate of polymorphonucler cells. Achieved data showed PMN cells in foot pad of rats dosed simvastatin 5mg/kg, 10 mg/kg decreased significantly (P<0.001). PMN cells in Control group were 35±2.54, Simvatatin 5mg/kg were 16.2± 1.48 and Simvastatin 10 mg/kg were 11±2.23.

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APA: Copy

ZIAEI, M., ANDALIB, S., GARJANI, A.R., & ZAKHERI, A.. (2007). STUDY OF THE ANTI-INFLAMMATORY EFFECTS OF SIMVASTATIN IN CARRAGEENAN INDUCED FOOTPAD EDEMA IN RATS. IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. SID. https://sid.ir/paper/904740/en

Vancouver: Copy

ZIAEI M., ANDALIB S., GARJANI A.R., ZAKHERI A.. STUDY OF THE ANTI-INFLAMMATORY EFFECTS OF SIMVASTATIN IN CARRAGEENAN INDUCED FOOTPAD EDEMA IN RATS. 2007. Available from: https://sid.ir/paper/904740/en

IEEE: Copy

M. ZIAEI, S. ANDALIB, A.R. GARJANI, and A. ZAKHERI, “STUDY OF THE ANTI-INFLAMMATORY EFFECTS OF SIMVASTATIN IN CARRAGEENAN INDUCED FOOTPAD EDEMA IN RATS,” presented at the IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. 2007, [Online]. Available: https://sid.ir/paper/904740/en

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