TRACHEAL RESPONSIVENESS TO METHACHOLINE AND MUSCARINC RECEPTOR BLOCKADE BLOCKADE BY ATROPINE IN AN ANIMAL MODEL OF COPD

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JANDAGHI P.; BOSKABADI M.H.

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Seminar Paper

Paper Information

Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Year:2007 | Issue:18

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Title

TRACHEAL RESPONSIVENESS TO METHACHOLINE AND MUSCARINC RECEPTOR BLOCKADE BLOCKADE BY ATROPINE IN AN ANIMAL MODEL OF COPD

Author(s)

JANDAGHI P. | BOSKABADI M.H.

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Abstract

Background: Airway hyperresponsiveness (AHR) is the main characteristic of asthma witch also exists in cigarette smokers. The mechanism of a competitive antagonism blockade is far simpler than that of agonists and depends only on drug delivery to the receptor sites and receptor affinity. Therefore, in this study we have examined the muscarinic receptor blockade by atropine in tracheal chains of an animal model of COPD.Methods: An experimental model of COPD was induced in guinea pigs by exposing to cigarette smoke for three months. The responses of tracheal chains of COPD and control animals (for each group n=7) to methacholine (as EC50) in the absence and presence of 10nM atropine and atropine blockade (CR-1) were measured.Results: The tracheal responses of COPD animals were significantly higher than controls (EC50; 0.80±0.22 vs 4.19±1.08 µM) (p<0.001). The (CR-1) value was also significantly higher in trachea of COPD compared to controls (19.94±3.79 vs 2.73±3.19, p<0.005). There was a significant correlation between EC50 M and (CR-1) (r=-0.639, p<0.05).Conclusion: The enhanced muscarinic receptor blockade, increased tracheal response to methacholine in tracheal chains of COPD animals and significant correlation between these two phenomenan may indicate that increased drug delivery to the receptors could also be a determinant factor for bronchial responsiveness to stimuli in COPD.

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APA: Copy

JANDAGHI, P., & BOSKABADI, M.H.. (2007). TRACHEAL RESPONSIVENESS TO METHACHOLINE AND MUSCARINC RECEPTOR BLOCKADE BLOCKADE BY ATROPINE IN AN ANIMAL MODEL OF COPD. IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. SID. https://sid.ir/paper/904813/en

Vancouver: Copy

JANDAGHI P., BOSKABADI M.H.. TRACHEAL RESPONSIVENESS TO METHACHOLINE AND MUSCARINC RECEPTOR BLOCKADE BLOCKADE BY ATROPINE IN AN ANIMAL MODEL OF COPD. 2007. Available from: https://sid.ir/paper/904813/en

IEEE: Copy

P. JANDAGHI, and M.H. BOSKABADI, “TRACHEAL RESPONSIVENESS TO METHACHOLINE AND MUSCARINC RECEPTOR BLOCKADE BLOCKADE BY ATROPINE IN AN ANIMAL MODEL OF COPD,” presented at the IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. 2007, [Online]. Available: https://sid.ir/paper/904813/en

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