PREVENTIONAL EFFECT OF GRAPEFRUIT JUICE (CITRUS PARADISI MACF.) ON WITHDRAWAL SYMPTOMS IN RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SARKAKI A.R.; SADIPOUR KH.; GHARIB NASERI MOHAMMAD KAZEM; BADAVI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Seminar Paper

Paper Information

Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Year:2007 | Issue:18

Download Full-Text

View:

130

Download:

Information Seminar Paper

Title

PREVENTIONAL EFFECT OF GRAPEFRUIT JUICE (CITRUS PARADISI MACF.) ON WITHDRAWAL SYMPTOMS IN RATS

Author(s)

SARKAKI A.R. | SADIPOUR KH. | GHARIB NASERI MOHAMMAD KAZEM | BADAVI M.

Keywords

Not Registered.

Abstract

Introduction: Addiction to opiates such as morphine is one of major public health problems. It has been shown that in addicted animals, administration of antioxidant agents such as vitamin C can reduce the withdrawal symptoms (WDS). The aim of this study was to evaluate the preventional effect of grapefruit juice (GPJ) on withdrawal symptoms in rats.Methods: Sixteen young male Wistar rats (250-300gr) randomly divided into two groups (n=8). The first group received 2 ml GFJ, 1 hour before morphine administration orally once a day for 9 days (the first 3 days: 10 mg/kg, the second 3 days: 20 mg/kg and the last 3 days 40 mg/kg; i.p). In the control group 2 ml of normal saline was administrated instead of GFJ. In the 10th day naloxone (10mg/kg,s.c), 45 minutes after injection of morphine (40 mg/kg; i.p) administrated for WDS inducing. Then WDS such as wet-dog shaking, teeth chattering, frequency of defecation and frequency of penis licking were evaluated for 30 minutes. Results: All of the above mentioned withdrawal symptoms reduced in the GFJ preventional group in comparison with the control group significantly (p<0.05, student t-test).Conclusion: The results of this study show that presumably antioxidant activity of GFJ can reduce WDS. Although the exact mechanisms of its effect in brain need to be determined.

Multimedia

No record.

Cites

No record.

References

No record.

Cite

APA: Copy

SARKAKI, A.R., SADIPOUR, KH., GHARIB NASERI, MOHAMMAD KAZEM, & BADAVI, M.. (2007). PREVENTIONAL EFFECT OF GRAPEFRUIT JUICE (CITRUS PARADISI MACF.) ON WITHDRAWAL SYMPTOMS IN RATS. IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. SID. https://sid.ir/paper/904829/en

Vancouver: Copy

SARKAKI A.R., SADIPOUR KH., GHARIB NASERI MOHAMMAD KAZEM, BADAVI M.. PREVENTIONAL EFFECT OF GRAPEFRUIT JUICE (CITRUS PARADISI MACF.) ON WITHDRAWAL SYMPTOMS IN RATS. 2007. Available from: https://sid.ir/paper/904829/en

IEEE: Copy

A.R. SARKAKI, KH. SADIPOUR, MOHAMMAD KAZEM GHARIB NASERI, and M. BADAVI, “PREVENTIONAL EFFECT OF GRAPEFRUIT JUICE (CITRUS PARADISI MACF.) ON WITHDRAWAL SYMPTOMS IN RATS,” presented at the IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. 2007, [Online]. Available: https://sid.ir/paper/904829/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops