THE EFFECT OF CHLORPROMAZINE ON ANTINOCICEPTION INDUCED BY SWIM-STRESS

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NASRI S.; KABIRZADEH M.

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Seminar Paper

Paper Information

Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Year:2007 | Issue:18

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Title

THE EFFECT OF CHLORPROMAZINE ON ANTINOCICEPTION INDUCED BY SWIM-STRESS

Author(s)

NASRI S. | KABIRZADEH M.

Keywords

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Abstract

Introduction: Exposure to a variety of environmental stressors has been shown to produce pain inhibition in animals. Stress-induced antinociception is a complex phenomenon, which depends on the animal species, nature of stress, intensity and type of noxious stimuli. It is suggested that in various models of stress, opioid and nonopioid pathways have been implicated.Methods: Male mice (25±5gr) were used in this study. Mice were Injected intraperitonally with Chlorpromazine (0.6, 1.25, 2.5, 5 mg/kg) and they were made to swim in water for a period of 3 minutes (20°C). We use formalin test to investigate chronic and acute pain.Results: Chlorpromazin produced antinoceptive effect in chronic phase. Swim stress induced antinociception but it had no interaction with Chlorpromazine.Conclusion: Swim stress in cold water produces antinociception via nonopioid pathways and also Chlorpromazine on antinociception which may activate nonopioid pathways as central monoaminergic pathways. So it seems that they both act via the same pathway.

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APA: Copy

NASRI, S., & KABIRZADEH, M.. (2007). THE EFFECT OF CHLORPROMAZINE ON ANTINOCICEPTION INDUCED BY SWIM-STRESS. IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. SID. https://sid.ir/paper/904992/en

Vancouver: Copy

NASRI S., KABIRZADEH M.. THE EFFECT OF CHLORPROMAZINE ON ANTINOCICEPTION INDUCED BY SWIM-STRESS. 2007. Available from: https://sid.ir/paper/904992/en

IEEE: Copy

S. NASRI, and M. KABIRZADEH, “THE EFFECT OF CHLORPROMAZINE ON ANTINOCICEPTION INDUCED BY SWIM-STRESS,” presented at the IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. 2007, [Online]. Available: https://sid.ir/paper/904992/en

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