CHLOROPLAST ENGINEERING FOR BIOPHARMACEUTICALS PRODUCTION

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RAHMANI M.; AALAMI SAEID KH.; ABBASZADEH SH.

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Seminar Paper

Paper Information

Seminar: HAMAYESHE MANTAGHEI KARBORD FANAVARIHAYE NOVIN DAR KESHAVARZI
Year:2008 | Issue:1

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Title

CHLOROPLAST ENGINEERING FOR BIOPHARMACEUTICALS PRODUCTION

Author(s)

RAHMANI M. | AALAMI SAEID KH. | ABBASZADEH SH.

Keywords

CHLOROPLAST GENETIC ENGINEERING

BIOPHARMACEUTICALS

PROTEIN

Abstract

IN RECENT TIMES, ENGINEERING OF PLANT GENOMES IN ORDER TO SIMPLE AND COMPLEX BIOPRODUCTS FOR THERAPEUTIC PURPOSES HAD A SALIENT INCREASE. THE CHLOROPLAST GENETIC ENGINEERING OFFERS A NUMBER OF UNIQUE ADVANTAGES INCLUDING HIGH LEVEL OF TRANSGENE EXPRESSION, MULTI-GENE EXPRESSION IN SINGLE TRANSFORMATION EVENT AND TRANSGENE CONTAINMENT DUE TO MATERNAL INHERITANCE. HYPER EXPRESSION OF DRUGS OR THERAPEUTIC PROTEINS IN TRANSGENIC CHLOROPLASTS OR CHROMOPLASTS FACILITATES EFFICIENT THERAPEUTIC PROCESS. ABILITY OF CHLOROPLASTS TO CORRECTLY FOLD HUMAN BLOOD PROTEINS WITH PROPER DISULFIDE BRIDGES (HUMAN SERUM ALBUMIN) OR PRESENCE OF CHAPERONES IN CHLOROPLASTS TO FACILITATE ASSEMBLY OF COMPLEX MULTI-SUBUNIT PROTEINS OR THEIR PROKARYOTIC NATURE TO EXPRESS NATIVE BACTERIAL GENES ARE ATTRACTIVE FEATURES FOR THERAPEUTIC PROTEIN PRODUCTION. PURIFICATION OF THERAPEUTIC PROTEINS HAS BEEN ACHIEVED USING NOVEL PURIFICATION STRATEGIES THAT DO NOT REQUIRE EXPENSIVE COLUMN CHROMATOGRAPHY.

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APA: Copy

RAHMANI, M., AALAMI SAEID, KH., & ABBASZADEH, SH.. (2008). CHLOROPLAST ENGINEERING FOR BIOPHARMACEUTICALS PRODUCTION. Hamayesh Mantaghei karbord fanavarihaye Novin Dar keshavarzi. SID. https://sid.ir/paper/905152/en

Vancouver: Copy

RAHMANI M., AALAMI SAEID KH., ABBASZADEH SH.. CHLOROPLAST ENGINEERING FOR BIOPHARMACEUTICALS PRODUCTION. 2008. Available from: https://sid.ir/paper/905152/en

IEEE: Copy

M. RAHMANI, KH. AALAMI SAEID, and SH. ABBASZADEH, “CHLOROPLAST ENGINEERING FOR BIOPHARMACEUTICALS PRODUCTION,” presented at the Hamayesh Mantaghei karbord fanavarihaye Novin Dar keshavarzi. 2008, [Online]. Available: https://sid.ir/paper/905152/en

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