GENETICS IN OBESITY & METABOLIC SYNDROME

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JOWETT JEREMY

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Seminar Paper

Paper Information

Seminar: INTERNATIONAL CONGRESS OF METABOLIC SYNDROME, OBESITY & DIABETES
Year:2010 | Issue:2

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Title

GENETICS IN OBESITY & METABOLIC SYNDROME

Author(s)

JOWETT JEREMY

Keywords

Not Registered.

Abstract

THE METABOLIC SYNDROME IS A CONSTELLATION OF TRAITS THAT INCLUDES OBESITY, DYSLIPIDEMIA, GLUCOSE INTOLERANCE AND HYPERTENSION. IT HAS BEEN OBSERVED THAT THESE TRAITS CLUSTER TOGETHER IN AN INDIVIDUAL MORE OFTEN THAN WOULD BE EXPECTED TO OCCUR BY CHANCE. IN DEVELOPING COUNTRIES, THE RAPID INCREASE IN THE PREVALENCE OF THESE DISORDERS HAS BEEN ACCOMPANIED BY AN EQUALLY RAPID INCREASE IN MORBIDITY AND MORTALITY FROM CARDIOVASCULAR DISEASE DRIVEN JOINTLY BY GENETIC PREDISPOSITION AND AN INCREASINGLY PERMISSIVE ENVIRONMENT. EACH OF THE METABOLIC SYNDROME COMPONENTS SHOW STRONG AND STATISTICALLY SIGNIFICANT HERITABILITY, THAT IS THEY TEND TO "RUN IN FAMILIES". NUMEROUS EFFORTS HAVE BEEN MADE TO IDENTIFY THE GENETIC BASIS OF THIS FAMILIAL RISK INCLUDING CANDIDATE GENE STUDIES, GENOME WIDE LINKAGE IN FAMILIES AND MORE RECENTLY GENOME WIDE ASSOCIATION STUDIES. MUCH HAS BEEN ACHIEVED, BUT THE MAJORITY OF THE FAMILIAL RISK REMAINS TO BE IDENTIFIED. ELUCIDATING THE GENETIC AND ENVIRONMENTAL COMPLEXITY IS KEY TO UNDERSTANDING THE PATHOGENESIS OF THE METABOLIC SYNDROME, AND TO BRING ABOUT THE DEVELOPMENT EFFECTIVE TREATMENTS FOR THOSE AFFLICTED.

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References

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Cite

APA: Copy

JOWETT, JEREMY. (2010). GENETICS IN OBESITY & METABOLIC SYNDROME. INTERNATIONAL CONGRESS OF METABOLIC SYNDROME, OBESITY & DIABETES. SID. https://sid.ir/paper/905192/en

Vancouver: Copy

JOWETT JEREMY. GENETICS IN OBESITY & METABOLIC SYNDROME. 2010. Available from: https://sid.ir/paper/905192/en

IEEE: Copy

JEREMY JOWETT, “GENETICS IN OBESITY & METABOLIC SYNDROME,” presented at the INTERNATIONAL CONGRESS OF METABOLIC SYNDROME, OBESITY & DIABETES. 2010, [Online]. Available: https://sid.ir/paper/905192/en

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