SHOULD TRIGLYCERIDE BE TARGET TO REDUCE CVD EVENTS?

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HOSSEIN PANAHI FARHAD

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Seminar Paper

Paper Information

Seminar: INTERNATIONAL CONGRESS OF METABOLIC SYNDROME, OBESITY & DIABETES
Year:2010 | Issue:2

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Title

SHOULD TRIGLYCERIDE BE TARGET TO REDUCE CVD EVENTS?

Author(s)

HOSSEIN PANAHI FARHAD

Keywords

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Abstract

THE SERUM TRIGLYCERIDE CONCENTRATION CAN BE STRATIFIED IN TERMS OF CORONARY RISK. NORMAL < 150 MG/DL, BORDERLINE HIGH 150 TO 199 MG/DL, HIGH 200 TO 499 MG/DL, VERY HIGH ≥ 500 MG/DL. THE ROLE OF TRIGLYCERIDES IN PROMOTING CARDIOVASCULAR DISEASE (CVD) IS STILL DEBATED MORE THAN 60 YEARS AFTER A RELATIONSHIP WAS FIRST POSTULATED. RECENT DATA FOCUSING ON THE POTENTIAL IMPORTANCE OF NONFASTING TRIGLYCERIDE LEVELS SEEM TO SETTLE THIS DEBATE BY ESTABLISHING A CONSISTENT STRONG RELATION OF TRIGLYCERIDES WITH CVD RISK. A RECENT META-ANALYSIS USING 29 PROSPECTIVE STUDIES CONDUCTED IN WESTERN POPULATIONS AGAIN NOTED THAT TG CONCENTRATIONS WERE AN INDEPENDENT RISK FACTOR FOR CORONARY HEART DISEASE IN BOTH SEXES. MOREOVER CHANGE IN TG CONCENTRATIONS HAS BEEN SHOWN TO RESULT IN CHANGE IN THE RISK OF DEVELOPING INCIDENT CORONARY HEART DISEASE. HOWEVER TWO IMPORTANT QUESTIONS REMAIN UNANSWERED. 1) HOW CAN DISTINGUISH THE EFFECTS OF TRIGLYCERIDES ON CHD RISK FROM THAT OF LOW HDL-C, OR FROM THAT OF INSULIN RESISTANCE PER SE. 2) IS IT APPROPRIATE TO ADJUST FOR HDL-C, WHICH IS STRONGLY INVERSELY CORRELATED WITH TRIGLYCERIDES AND ALSO BIOLOGICALLY LINKED TO INSULIN RESISTANCE IN MULTIVARIABLE ANALYSES. RECOMMENDATIONS FOR THE THERAPY OF HYPERTRIGLYCERIDEMIA HAVE BEEN LIMITED BY PREVIOUSLY INCONSISTENT EPIDEMIOLOGIC STUDIES, THE INTERRELATIONSHIP BETWEEN TRIGLYCERIDES WITH HDL AND OTHER RISK FACTORS, AND THE LACK OF CONCLUSIVE DATA THAT TRIGLYCERIDE LOWERING CAN REDUCE CHD RISK. A MAJOR QUESTION IN MANAGEMENT IS WHETHER THERAPY SHOULD BE DIRECTED SOLELY TOWARD REDUCTION OF TRIGLYCERIDE LEVELS OR TOWARD THE MODIFICATION OF ASSOCIATED ABNORMALITIES OF INTERMEDIATE-DENSITY LIPOPROTEIN, LDL, AND HDL CHOLESTEROL. THE BENEFIT OF TREATING MILD-TOMODERATE ELEVATIONS IN TRIGLYCERIDE LEVELS IS LESS CLEAR.

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Cite

APA: Copy

HOSSEIN PANAHI, FARHAD. (2010). SHOULD TRIGLYCERIDE BE TARGET TO REDUCE CVD EVENTS?. INTERNATIONAL CONGRESS OF METABOLIC SYNDROME, OBESITY & DIABETES. SID. https://sid.ir/paper/905194/en

Vancouver: Copy

HOSSEIN PANAHI FARHAD. SHOULD TRIGLYCERIDE BE TARGET TO REDUCE CVD EVENTS?. 2010. Available from: https://sid.ir/paper/905194/en

IEEE: Copy

FARHAD HOSSEIN PANAHI, “SHOULD TRIGLYCERIDE BE TARGET TO REDUCE CVD EVENTS?,” presented at the INTERNATIONAL CONGRESS OF METABOLIC SYNDROME, OBESITY & DIABETES. 2010, [Online]. Available: https://sid.ir/paper/905194/en

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