ENVIRONMENTAL ESTROGENS, COSMETICS AND BREAST CANCER

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EBRAHIMI M.; SHAMABADI N.

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Seminar Paper

Paper Information

Seminar: HAMAYESH MELLI ENSAN, MOHITE ZIST VA TOSEE PAYDAR
Year:2010 | Issue:0

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Information Seminar Paper

Title

ENVIRONMENTAL ESTROGENS, COSMETICS AND BREAST CANCER

Author(s)

EBRAHIMI M. | SHAMABADI N.

Keywords

ESTROGEN

ENVIRONMENTAL ESTROGEN

COSMETICS

BREAST CANCER

Abstract

THE ESTABLISHED ROLE OF ESTROGEN IN THE DEVELOPMENT AND PROGRESSION OF BREAST CANCER RAISES QUESTIONS CONCERNING A POTENTIAL CONTRIBUTION FROM THE MANY CHEMICALS IN THE ENVIRONMENT WHICH CAN ENTER THE HUMAN BREAST AND WHICH HAVE ESTROGENIC ACTIVITY. ALTHOUGH BREAST CANCER MAY NOT BE A NEW DISEASE, THE INCIDENCE OF FEMALE BREAST CANCER HAS RISEN WORLDWIDE IN UNPRECEDENTED TERMS IN RECENT DECADES. EPIDEMIOLOGICAL STUDIES SHOW THAT 90% OF BREAST CANCERS ARE ENVIRONMENTAL IN ORIGIN. THE MAIN INFLUENCE IN THE DEVELOPMENT OF BREAST CANCER REMAINS LIFETIME EXPOSURE TO ESTROGEN.A RANGE OF ORGAN CHLORINE PESTICIDES AND POLYCHLORINATED BIPHENYLS POSSESS ESTROGEN-MIMICKING PROPERTIES AND HAVE BEEN MEASURED IN HUMAN BREAST ADIPOSE TISSUE AND IN HUMAN MILK. THESE ENTER THE BREAST FROM VARIED ENVIRONMENTAL CONTAMINATION OF FOOD, WATER AND AIR, AND DUE TO THEIR LIPOPHILIC PROPERTIES CAN ACCUMULATE IN BREAST FAT. HOWEVER, IT IS EMERGING THAT THE BREAST IS ALSO EXPOSED TO A RANGE OF ESTROGENIC CHEMICALS APPLIED AS COSMETICS TO THE UNDERARM AND BREAST AREA. THESE COSMETICS ARE LEFT ON THE SKIN IN THE APPROPRIATE AREA, ALLOWING A MORE DIRECT DERMAL ABSORPTION ROUTE FOR BREAST EXPOSURE TO ESTROGENIC CHEMICALS AND ALLOWING ABSORBED CHEMICALS TO ESCAPE SYSTEMIC METABOLISM. THIS REVIEW CONSIDERS EVIDENCE IN SUPPORT OF A FUNCTIONAL ROLE FOR THE COMBINED INTERACTIONS OF MECHANISMS OF DISRUPTING EFFECTS OF ENVIRONMENTAL HORMONE AND NATURAL HORMONE, COSMETIC CHEMICALS WITH ENVIRONMENTAL ESTROGENS, PHARMACOLOGICAL ESTROGENS, PHYTO-ESTROGENS AND PHYSIOLOGICAL ESTROGENS IN THE RISING INCIDENCE OF BREAST CANCER.

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Cite

APA: Copy

EBRAHIMI, M., & SHAMABADI, N.. (2010). ENVIRONMENTAL ESTROGENS, COSMETICS AND BREAST CANCER. HAMAYESH MELLI ENSAN, MOHITE ZIST VA TOSEE PAYDAR. SID. https://sid.ir/paper/905935/en

Vancouver: Copy

EBRAHIMI M., SHAMABADI N.. ENVIRONMENTAL ESTROGENS, COSMETICS AND BREAST CANCER. 2010. Available from: https://sid.ir/paper/905935/en

IEEE: Copy

M. EBRAHIMI, and N. SHAMABADI, “ENVIRONMENTAL ESTROGENS, COSMETICS AND BREAST CANCER,” presented at the HAMAYESH MELLI ENSAN, MOHITE ZIST VA TOSEE PAYDAR. 2010, [Online]. Available: https://sid.ir/paper/905935/en

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