FABRICATION OF A POROUS COMPOSITE SCAFFOLD BASED ON GELATIN AND HYDROXYAPATITE FOR BONE TISSUE ENGINEERING AND EVALUATION OF CELL ATTACHMENT

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ASKARZADEH TABRIZI KARIM; ORANG FARIBA; MOZTARZADEH FATHOLLAH

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Seminar Paper

Paper Information

Seminar: IRANIAN CONFERENCE ON BIOMEDICAL ENGINEERING
Year:2004 | Issue:11

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Title

FABRICATION OF A POROUS COMPOSITE SCAFFOLD BASED ON GELATIN AND HYDROXYAPATITE FOR BONE TISSUE ENGINEERING AND EVALUATION OF CELL ATTACHMENT

Author(s)

ASKARZADEH TABRIZI KARIM | ORANG FARIBA | MOZTARZADEH FATHOLLAH

Keywords

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Abstract

GELATIN IS A PROTEIN DERIVED FROM THE ORGANIC CONSTITUENT OF BONE (COLLAGEN). COMBINATION OF THIS PROTEIN WITH THE INORGANIC CONSTITUENT (HYDROXYAPATITE) WOULD PROVIDE MUCH CLOSER PROPERTIES TO THE NATURAL BONE. THUS IN THIS STUDY A COMPOSITE SCAFFOLD BASED ON GELATIN AND HYDROXYAPATITE WAS OFFERED AS A BIODEGRADABLE SUBSTITUTE FOR BONE TISSUE. FABRICATION OF SUCH SCAFFOLDS WAS CARRIED OUT BY SOLVENT CASTING METHOD WITHOUT USING ANY ORGANIC SOLVENT INCREASING THE BIOCOMPATIBILITY LEVEL. POROSITIES OBTAINED HERE WERE QUITE SPONTANEOUS WITHOUT THE AID OF POROGENS. THE PORES INDICATED HIGH INTERCONNECTIVITIES WITH DIAMETERS RANGING FROM 50 TO 200 MICRONS, WHICH IS MUCH APPROPRIATE FOR BONE TISSUE ENGINEERING APPLICATIONS. IN ORDER TO STUDY THE BIOCOMPATIBILITY OF THE SCAFFOLDS, MOUSE FIBROBLASTIC CELLS WERE USED. AFTER 24-HOUR CELL CULTURE PERIOD, IN VITRO, SUITABLE CELL ATTACHMENT WAS OBSERVED SHOWING HIGH BIOCOMPATIBILITY FOR ALL THE SAMPLES. FURTHER EXAMINATIONS DEMONSTRATED THAT THE BEST BIOCOMPATIBILITY IS RELATED TO COMPOSITE OF 50 WT% HYDROXYAPATITE AND 50 WT% GELATIN.

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APA: Copy

ASKARZADEH TABRIZI, KARIM, ORANG, FARIBA, & MOZTARZADEH, FATHOLLAH. (2004). FABRICATION OF A POROUS COMPOSITE SCAFFOLD BASED ON GELATIN AND HYDROXYAPATITE FOR BONE TISSUE ENGINEERING AND EVALUATION OF CELL ATTACHMENT. IRANIAN CONFERENCE ON BIOMEDICAL ENGINEERING. SID. https://sid.ir/paper/906413/en

Vancouver: Copy

ASKARZADEH TABRIZI KARIM, ORANG FARIBA, MOZTARZADEH FATHOLLAH. FABRICATION OF A POROUS COMPOSITE SCAFFOLD BASED ON GELATIN AND HYDROXYAPATITE FOR BONE TISSUE ENGINEERING AND EVALUATION OF CELL ATTACHMENT. 2004. Available from: https://sid.ir/paper/906413/en

IEEE: Copy

KARIM ASKARZADEH TABRIZI, FARIBA ORANG, and FATHOLLAH MOZTARZADEH, “FABRICATION OF A POROUS COMPOSITE SCAFFOLD BASED ON GELATIN AND HYDROXYAPATITE FOR BONE TISSUE ENGINEERING AND EVALUATION OF CELL ATTACHMENT,” presented at the IRANIAN CONFERENCE ON BIOMEDICAL ENGINEERING. 2004, [Online]. Available: https://sid.ir/paper/906413/en

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