SYNTHESIS AND CHARACTERIZATION OF NOVEL SUBSTITUTED OF 1, 3, 4- THIADIAZOLE AND 1, 3, 4- OXADIAZOLE

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SEYYED SHAHABI SOULMAZ; GHARIBI MAHTAB

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Seminar Paper

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Seminar: IRANIAN SEMINAR OF ORGANIC CHEMISTRY
Year:2012 | Issue:19

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Title

SYNTHESIS AND CHARACTERIZATION OF NOVEL SUBSTITUTED OF 1, 3, 4- THIADIAZOLE AND 1, 3, 4- OXADIAZOLE

Author(s)

SEYYED SHAHABI SOULMAZ | GHARIBI MAHTAB

Keywords

Not Registered.

Abstract

A NEW SERIES OF 5- (ISOMERIC PYRIDYL) - 1, 3, 4- OXADIAZOLE 3 (A-C) AND THIADIAZOLE 4 (A-C), DERIVATIVES WERE SYNTHESIZED IN EXCELLENT YIELD AND TO OBTAIN NEW COMPOUNDS WITH POTENTIAL SIGNIFICANT BIOLOGICAL ACTIVITY. THE STARTING COMPOUND, THIOSEMICARBAZIDES 2 (A-C), WERE USED AS THE KEY INTERMEDIATES FOR THE SYNTHESIS OF HETEROCYCLIC COMPOUNDS. THE STRUCTURE OF THE TARGET COMPOUNDS WERE CONFIRMED BY IR, 1H-NMR, AND MS SPECTROSCOPY.THE NEW OXADIAZOLE AND THIADIAZOLE DERIVATIVES WERE PREPARED FOLLOWING THE REACTION SEQUENCES DEPICTED IN SCHEME 1. THE STARTING MATERIAL FOR THE SYNTHESIS OF THE TARGETED COMPOUNDS IS THIOSEMICARBAZIDE, WHICH WAS PREPARED BY THE REACTION 4-HALO PHENYL ISOTHIOCYANATE AND ISOMERIC PYRIDINE CARBOXYLIC ACID HYDRAZIDES 1 (A-C) IN ETHANOL MEDIA.THEREFORE 2- (4- HALOANILINE) - 5 - (ISOMERIC PYRIDYL) - 1, 3, 4- THIADIAZOLE AND 2- (4- HALOANILINE)-5- (ISOMERIC PYRIDYL) - 1, 3, 4-OXADIAZOLE WERE REACTED WITH CORRESPONDING REAGENTS PRODUCTS. FROM THE PRESENT STUDY, IT CAN PROMOT FUTURE RESEARCHER TO SYNTHESIZE A SERIES OF THESE COMPOUNDS CONTAINING WIDE VARIETIES OF SUBSTITUENT WITH THE AIM OF OBTAINING SOME NOVEL HETEROCYCLIC SYSTEMS WITH ENHANCED MEDICAL PROPERTIES.

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APA: Copy

SEYYED SHAHABI, SOULMAZ, & GHARIBI, MAHTAB. (2012). SYNTHESIS AND CHARACTERIZATION OF NOVEL SUBSTITUTED OF 1, 3, 4- THIADIAZOLE AND 1, 3, 4- OXADIAZOLE. IRANIAN SEMINAR OF ORGANIC CHEMISTRY. SID. https://sid.ir/paper/909471/en

Vancouver: Copy

SEYYED SHAHABI SOULMAZ, GHARIBI MAHTAB. SYNTHESIS AND CHARACTERIZATION OF NOVEL SUBSTITUTED OF 1, 3, 4- THIADIAZOLE AND 1, 3, 4- OXADIAZOLE. 2012. Available from: https://sid.ir/paper/909471/en

IEEE: Copy

SOULMAZ SEYYED SHAHABI, and MAHTAB GHARIBI, “SYNTHESIS AND CHARACTERIZATION OF NOVEL SUBSTITUTED OF 1, 3, 4- THIADIAZOLE AND 1, 3, 4- OXADIAZOLE,” presented at the IRANIAN SEMINAR OF ORGANIC CHEMISTRY. 2012, [Online]. Available: https://sid.ir/paper/909471/en

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