REAL TIME ASSESSMENT OF DRUG-RELEASE PROFILE FROM THERAPEUTIC NANOPARTICLES USING OF AMPEROMETRY

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HEDARI BAFROOEI ESMAEIL; ENSAFI ALI A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Seminar Paper

Paper Information

Seminar: IRANIAN CHEMISTRY CONGRESS
Year:2014 | Issue:17

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Title

REAL TIME ASSESSMENT OF DRUG-RELEASE PROFILE FROM THERAPEUTIC NANOPARTICLES USING OF AMPEROMETRY

Author(s)

HEDARI BAFROOEI ESMAEIL | ENSAFI ALI A. | Issue Writer Certificate

Keywords

DRUG RELEASE

VOLTAMMETRY

DOXORUBICIN

LIPOSOME

NANOPARTICLES

Abstract

BACKGROUND: IN THE PAST TWO DECADES, THERE HAS BEEN A STEADY RISE IN THE NUMBER OF COMMERCIALLY AVAILABLE NANOPARTICLE-BASED THERAPEUTIC PRODUCTS [1-2]. IDEALLY, A SUCCESSFUL NANOPARTICULATE SYSTEM AS A DRUG CARRIER SHOULD HAVE A HIGH DRUG LOADING CAPACITY THEREBY REDUCING THE QUANTITY OF MATRIX MATERIAL FOR ADMINISTRATION AND A CONTROLLED RELEASE DRUG DELIVERY TO ACHIEVE THE CORRECT DOSE OF DRUG AT ONLY THE DISEASE SITE WITH THE MOST EFFECTIVE RELEASE PROFILE. THEREFORE, CONTROLLING THE RATE OF DRUG RELEASE FROM CARRIERS IS ESSENTIAL FOR OPTIMUM DRUG DELIVERY.METHODS: THE METHOD IS BASED ON THE MULTIPLE PULSE AMPEROMETRIC MEASUREMENT OF THE OXIDATION AND REDUCTION OF DOXORUBICIN RELEASED FROM LIPOSOME A T A MWCNTS MODIFIED GLASSY CARBON ELECTRODE (MWCNT-GCE). THE RELEASED DOXORUBICIN WAS DETECTED AT + 0.60 AND 0.60 V BY TWO DIFFERENT OXIDATION. AND REDUCTION PROCESSES, RESPECTIVELY. THE THIRD POTENTIAL PULSE (1.00 V) WAS APPLIED FOR THE REGENERATION OF MWCNT-GCE.RESULTS: THE PROPOSED PROCEDURE ALSO PROVIDES ACCURATE ASSESSMENT OF DRUG RELEASE PROFILE FROM LIPOSOMES IN SERUM. ALTHOUGH SEVERAL TECHNIQUES (SUCH AS GEL FILTRATION CHROMATOGRAPHY, ION EXCHANGE CHROMATOGRAPHY AND DIALYSIS) EXIST FOR DETERMINING THE AMOUNT OF UNTRAPPED DOXORUBICIN IN LIPOSOMAL SYSTEMS, THESE ARE GENERALLY TIME CONSUMING AND REQUIRE SPECIALIZED SCIENTIFIC EQUIPMENT. THE MPA ASSAY FOR RELEASED DOXORUBICIN DESCRIBED HERE DOES NOT REQUIRE THE USE OF CHROMATOGRAPHY AND DIALYSIS EQUIPMENT.CONCLUSION: THE OBTAINED RESULTS CONFIRMED THAT THE MPA IS A GOOD ALTERNATIVE METHOD TO THE OTHER EXISTING TECHNIQUES FOR MONITORING THE DRUG RELEASE PROFILE. THE MAIN ADVANTAGE OF THIS METHOD IS THAT THERE IS NO NEED FOR ANY OPERATION FOR THE QUANTITATIVE ANALYSIS DURING THE RELEASE OF THE DRUG FROM NANOPARTICLES.

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APA: Copy

HEDARI BAFROOEI, ESMAEIL, & ENSAFI, ALI A.. (2014). REAL TIME ASSESSMENT OF DRUG-RELEASE PROFILE FROM THERAPEUTIC NANOPARTICLES USING OF AMPEROMETRY. IRANIAN CHEMISTRY CONGRESS. SID. https://sid.ir/paper/911624/en

Vancouver: Copy

HEDARI BAFROOEI ESMAEIL, ENSAFI ALI A.. REAL TIME ASSESSMENT OF DRUG-RELEASE PROFILE FROM THERAPEUTIC NANOPARTICLES USING OF AMPEROMETRY. 2014. Available from: https://sid.ir/paper/911624/en

IEEE: Copy

ESMAEIL HEDARI BAFROOEI, and ALI A. ENSAFI, “REAL TIME ASSESSMENT OF DRUG-RELEASE PROFILE FROM THERAPEUTIC NANOPARTICLES USING OF AMPEROMETRY,” presented at the IRANIAN CHEMISTRY CONGRESS. 2014, [Online]. Available: https://sid.ir/paper/911624/en

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