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Information Seminar Paper

Title

N-NICOTINYL PHOSPHORAMIDES CONTAINING HETEROCYCLIC AMINE

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Abstract

 BACKGROUND: NICOTINAMIDE IS A PART OF THE PYRIDINE NUCLEOTIDES AS NADC AND NADPC THAT PLAYS A CRUCIAL ROLE IN BIOLOGICAL OXIDATIVE CHEMISTRY AND IS ESSENTIAL FOR THE HUMAN BODY [1, 2]. PHOSPHORAMIDES HAVE UNIQUE ANTI-HIV, ANTI-HCV, ANTIBACTERIAL AND ANTICANCER PROPERTIES [3].METHODS: FROM THE REACTION OF PCL5 AND NICOTINAMIDE, OXIDATION AND ADDING HETEROCYCLIC AMINE TO THE INTERMEDIATE AND THEN PURIFICATION WITH SOLVENTS WE SYNTHESIZED SOME NEW PHOSPHORAMIDES CONTAINING NICOTINAMIDE WITH FORMULA: C5H4NC (O) NHP (O) (R)2, R=NC4H8 (1), NC5H10 (2), NC6H12 (3), 4-CH3- NC5H9 (4), NC4H8O (5) AND CHARACTERIZED THEM BY 1H, 13C, 31P, NMR, IR SPECTROSCOPY, ELEMENTAL ANALYSIS AND X-RAY CRYSTALLOGRAPHY.RESULTS: 1HNMR SPECTRA OF COMPOUND 2 DEMONSTRATED LONG-RANGE PHOSPHOROUS-HYDROGEN COUPLING CONSTANT, NJP, H (N=5, 7). THE CRYSTAL STRUCTURE OF 3 WAS DETERMINED BY X-RAY CRYSTALLOGRAPHY (SEE BELOW). IT SHOWS THAT THE P-NAMIDE BONDS ARE LONGER THAN THE P-NAMINE BONDS AND THE C-NAMIDE BOND LENGTHS ARE SHORTER THAN THE C-NAMINE BOND LENGTHS.CONCLUSION: SOME NEW PHOSPHORAMIDES WERE SYNTHESIZED IN WHICH RESONANCE INTERACTION OF THE NAMIDE WITH THE C=O P SYSTEM CAUSES A PARTIAL MULTIPLE BOND CHARACTER IN C-NAMIDE.

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    APA: Copy

    OROUJZADEH, NASRIN, & GHOLIVAND, KHODAYAR. (2014). N-NICOTINYL PHOSPHORAMIDES CONTAINING HETEROCYCLIC AMINE. IRANIAN CHEMISTRY CONGRESS. SID. https://sid.ir/paper/913249/en

    Vancouver: Copy

    OROUJZADEH NASRIN, GHOLIVAND KHODAYAR. N-NICOTINYL PHOSPHORAMIDES CONTAINING HETEROCYCLIC AMINE. 2014. Available from: https://sid.ir/paper/913249/en

    IEEE: Copy

    NASRIN OROUJZADEH, and KHODAYAR GHOLIVAND, “N-NICOTINYL PHOSPHORAMIDES CONTAINING HETEROCYCLIC AMINE,” presented at the IRANIAN CHEMISTRY CONGRESS. 2014, [Online]. Available: https://sid.ir/paper/913249/en

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