A FACILE ONE POT SYNTHESIS OF NOVEL CALIX [4] ARENE BISPHOSPHONIC ACIDS

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ALAVIJEH NAHID S.; Zadmard Reza; RAMEZANPOUR SOROUR; BALALAIE SAEED

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Seminar Paper

Paper Information

Seminar: IRANIAN SEMINAR OF ORGANIC CHEMISTRY
Year:2014 | Issue:22

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Title

A FACILE ONE POT SYNTHESIS OF NOVEL CALIX [4] ARENE BISPHOSPHONIC ACIDS

Author(s)

ALAVIJEH NAHID S. | Zadmard Reza | RAMEZANPOUR SOROUR | BALALAIE SAEED | Issue Writer Certificate

Keywords

CALIX [4] ARENES

BISPHOSPHONIC ACIDS

BISPHOSPHONATES

ZOLENDRONATE

Abstract

DURING THE LAST 10 YEARS, CALIXARENE DERIVATIVES, ESPECIALLY WATER SOLUBLE AND AMPHIPHILIC ONES, HAVE BEEN THE SUBJECT OF GROWING INTEREST IN THE FIELD OF BIOLOGY. HIGHLY DIVERSE BIOMEDICAL APPLICATIONS OF THESE MOLECULES INCLUDE ANTIBACTERIAL, ANTICANCER, ANTIVIRAL, ANTITHROMBOTIC, MEMBRANOTROPIC ACTIVITIES, SELECTIVE ENZYME BLOCKING AND MIMICKING, AS WELL AS PROTEIN COMPLEXATION [1]. CALIXARENES, SUBSTITUTED AT THE UPPER OR/ AND LOWER MACROCYCLIC RIM WITH BIOLOGICALLY ACTIVE FUNCTIONAL GROUPS, ARE CONSIDERED AS PROMISING COMPOUNDS FOR TREATMENT OF MANY DISEASES [2-3].RECENTLY, THE DEVELOPMENT OF ORGANOPHOSPHORUS CHEMISTRY HAS BEEN IDENTIFIED BY A GREAT INTEREST IN BISPHOSPHONATES AND BISPHOSPHONIC ACIDS. THEY BIND TO BONE MINERALS AND INHIBIT THE RESORPTION OF LIVING BONE. IN CLINICAL MEDICINE, SEVERAL BISPHOSPHONATES (E.G., ZOLEDRONATE, ETIDRONATE, PAMIDRONATE, ALENDRONATE, RISEDRONATE AND IBANDRONATE) ARE ESTABLISHED AS EFFECTIVE TREATMENTS FOR BONE DISEASES SUCH AS PAGET’S DISEASE, MYELOMA, AND BONE METASTASES. IN ADDITION, ETIDRONATE AND ALENDRONATE ARE APPROVED FOR THE PREVENTION AND TREATMENT OF OSTEOPOROSIS [4].IN THIS STUDY, THE FIRST AND ONE POT SYNTHESIS OF CALIX [4] ARENE BEARING TWO BISPHOSPHONIC ACID GROUPS AT THE LOWER RIM FROM THE CORRESPONDING CALIX [4] ARENE CARBOXYLIC ACID IS DESCRIBED. THIS METHOD INVOLVES THE BISPHOSPHONATION OF THE CORRESPONDING CARBOXYLIC ACIDS IN A SINGLE SOLVENT TO PRODUCE THE DESIRED BISPHONATES. FURTHER STUDIES ARE UNDERWAY TO O EXPLORE THEIR POSSIBLE BIOLOGICAL ACTIVITIES. THIS METHOD IS USEFUL FOR THE PREPARATION OF OTHER BISPHOSPHONATE COMPOUNDS.

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APA: Copy

ALAVIJEH, NAHID S., Zadmard, Reza, RAMEZANPOUR, SOROUR, & BALALAIE, SAEED. (2014). A FACILE ONE POT SYNTHESIS OF NOVEL CALIX [4] ARENE BISPHOSPHONIC ACIDS. IRANIAN SEMINAR OF ORGANIC CHEMISTRY. SID. https://sid.ir/paper/914042/en

Vancouver: Copy

ALAVIJEH NAHID S., Zadmard Reza, RAMEZANPOUR SOROUR, BALALAIE SAEED. A FACILE ONE POT SYNTHESIS OF NOVEL CALIX [4] ARENE BISPHOSPHONIC ACIDS. 2014. Available from: https://sid.ir/paper/914042/en

IEEE: Copy

NAHID S. ALAVIJEH, Reza Zadmard, SOROUR RAMEZANPOUR, and SAEED BALALAIE, “A FACILE ONE POT SYNTHESIS OF NOVEL CALIX [4] ARENE BISPHOSPHONIC ACIDS,” presented at the IRANIAN SEMINAR OF ORGANIC CHEMISTRY. 2014, [Online]. Available: https://sid.ir/paper/914042/en

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