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Information Seminar Paper

Title

SYNTHESIS OF PYRANOPYRAZOLE-PYRIMIDINE HYBRIDS

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Abstract

 PYRANOPYRAZOLES ARE FUSED HETEROCYCLIC COMPOUNDS THAT EXHIBIT A WIDE RANGE OF BIOLOGICAL ACTIVITIES [1]. DUE TO THEIR BIOLOGICAL SIGNIFICANCE, THERE HAS BEEN CONSIDERABLE INTEREST IN DEVELOPING SYNTHETIC METHODS FOR PREPARATION OF PYRANOPYRAZOLE DERIVATIVES.FUSION OF PYRIMIDINE MOIETY WITH DIFFERENT HETEROCYCLE SCAFFOLDS GIVES RISE TO A NEW CLASS OF HYBRID HETEROCYCLES POSSESSING IMPROVED ACTIVITY [2].HEREIN WE WISH TO DESCRIBE THE SYNTHESIS OF NOVEL HYBRIDE COMPOUNDS, BASED ON A PYRANOPYRAZOLE AND A PYRIMIDINE. IN THIS WORK, FIRSTLYNOVEL 3-METHYL CARBOXYLATE SUBSTITUTED PYRANO [2,3-C] PYRAZOLES WERE PREPARED BY A CATALYST-FREE FOUR-COMPONENT REACTION OF DIMETHYL ACETYLENEDICARBOXYLATE, HYDRAZINE HYDRATE, MALONONITRILE AND AROMATIC ALDEHYDES IN WATER. THEN REACTION OF PYRANOPRRAZOLE DERIVATIVES WITH PHENYL ISOTHIOCYANATE IN PYRIDINE GAVE PYRANOPYRAZOLEPYRIMIDINE HYBRIDS (SCHEME 1).

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    APA: Copy

    MOSHTAGHI ZONOUZ, A., GHAFFARI, P., & POURREZA, A.. (2013). SYNTHESIS OF PYRANOPYRAZOLE-PYRIMIDINE HYBRIDS. IRANIAN CHEMISTRY CONGRESS. SID. https://sid.ir/paper/914860/en

    Vancouver: Copy

    MOSHTAGHI ZONOUZ A., GHAFFARI P., POURREZA A.. SYNTHESIS OF PYRANOPYRAZOLE-PYRIMIDINE HYBRIDS. 2013. Available from: https://sid.ir/paper/914860/en

    IEEE: Copy

    A. MOSHTAGHI ZONOUZ, P. GHAFFARI, and A. POURREZA, “SYNTHESIS OF PYRANOPYRAZOLE-PYRIMIDINE HYBRIDS,” presented at the IRANIAN CHEMISTRY CONGRESS. 2013, [Online]. Available: https://sid.ir/paper/914860/en

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