A COMPARATIVE STUDY ON THE SOYBEAN LIPOXYGENASEINHIBITORY ACTIVITIES OF ESTERAGOL DERIVATIVES

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

JAFARI Z.; SEYEDI S.M.; SADEGHIAN H.; ESHGHI H.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Seminar Paper

Paper Information

Seminar: IRANIAN CHEMISTRY CONGRESS
Year:2013 | Issue:16

Download Full-Text

View:

121

Download:

Information Seminar Paper

Title

A COMPARATIVE STUDY ON THE SOYBEAN LIPOXYGENASEINHIBITORY ACTIVITIES OF ESTERAGOL DERIVATIVES

Author(s)

JAFARI Z. | SEYEDI S.M. | SADEGHIAN H. | ESHGHI H. | Issue Writer Certificate

Keywords

Not Registered.

Abstract

IT IS WELL DOCUMENTED THAT MAMMALIAN LIPOXYGENASES (LOS) ARE NON-HEME IRON-CONTAINING ENZYMES RESPONSIBLE FOR THE OXIDATION OF POLYUNSATURATED FATTY ACIDS AND ESTERS TO HYDROPEROXY DERIVATIVES [1]. RECENTLY, 15-LIPOXYGENASE HAS EMERGED AS AN ATTRACTIVE TARGET FOR THERAPEUTIC INTERVENTION. IN ADDITION, THE IMMEDIATE PRODUCTS OF 15-LO OXIDATION OF AA AND LINOLEIC ACID HAVE BEEN SHOWN TO BE PRO-INFLAMMATORY AND PRO-THROMBOTIC [2]. THERE IS REASONABLE HOMOLOGY BETWEEN THE SOYBEAN LIPOXYGENASE (SLO) AND THE HUMAN ONE [3]. OBVIOUSLY SOYBEAN ENZYME IS MUCH MORE ACCESSIBLE THAN THE HUMAN ONE. THEREFORE, ONE CAN EXPECT THAT THE RESULTS CAN BE EXTENDABLE TO THE HUMAN LO.RECENTLY WE REPORTED THE RESULTS OF A COMPARATIVE STUDY ON SLO INHIBITORY ACTIVITIES OF EUGENOL, EUGENYL BENZOATE, METHYLEUGENOL AND ESTERAGOL. ALSO, WE SUGGESTED THAT THE INHIBITORY ACTIVITY OF THESE MOLECULES LARGELY DEPENDS ON THE ORIENTATION OF ALLYL GROUP TOWARDS CHELATED FE3+-OH AND THE MOLECULAR VOLUME OF CARBOXYLATE MOIETY IN ACTIVE SITE POCKET OF THE ENZYME WITHOUT HYDROPEROXIDATION OF ALLYLIC CARBONS. IN THIS WORK, WE DECIDED TO DEMETHYLATEESTERAGOL AND SYNTHESIZE THE BENZOATE ESTER AND STUDY ITS INHIBITORY POTENCY. BASED ON THE IC50 OF THIS ESTER COMPARING TO EUGENYL BENZOATE, IT IS SUGGESTED THAT THE METHOXY GROUP OF EUGENYL BENZOATE HAVE NO EFFECTIVE ROLE IN INHIBITORY POTENCY. THEN THE ALLYL GROUP OF THIS COMPOUND WAS REPLACED WITH ALLYLOXY TO STUDY ITS INHIBITORY POTENCY. THE RESULTS OF DOCKING ANALYSIS SHOWED THESE COMPOUNDS HAVE THE SIMILAR ESTIMATED INHIBITORY CONSTANT (KI) IN A RANGE OF 2-4×106.

Multimedia

No record.

Cites

No record.

References

No record.

Cite

APA: Copy

JAFARI, Z., SEYEDI, S.M., SADEGHIAN, H., & ESHGHI, H.. (2013). A COMPARATIVE STUDY ON THE SOYBEAN LIPOXYGENASEINHIBITORY ACTIVITIES OF ESTERAGOL DERIVATIVES. IRANIAN CHEMISTRY CONGRESS. SID. https://sid.ir/paper/914924/en

Vancouver: Copy

JAFARI Z., SEYEDI S.M., SADEGHIAN H., ESHGHI H.. A COMPARATIVE STUDY ON THE SOYBEAN LIPOXYGENASEINHIBITORY ACTIVITIES OF ESTERAGOL DERIVATIVES. 2013. Available from: https://sid.ir/paper/914924/en

IEEE: Copy

Z. JAFARI, S.M. SEYEDI, H. SADEGHIAN, and H. ESHGHI, “A COMPARATIVE STUDY ON THE SOYBEAN LIPOXYGENASEINHIBITORY ACTIVITIES OF ESTERAGOL DERIVATIVES,” presented at the IRANIAN CHEMISTRY CONGRESS. 2013, [Online]. Available: https://sid.ir/paper/914924/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops