SYNTHESIS OF 4,4’-(ARYLMETHYLENE) BIS (1H-PYRAZOL-5-OLS) USING PERCHLORATE SULFURIC ACID(PCSA) AS CATALYST

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IRAVANI N.; Perastehnejad E.

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Seminar Paper

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Seminar: IRANIAN CHEMISTRY CONGRESS
Year:2013 | Issue:16

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Title

SYNTHESIS OF 4,4’-(ARYLMETHYLENE) BIS (1H-PYRAZOL-5-OLS) USING PERCHLORATE SULFURIC ACID(PCSA) AS CATALYST

Author(s)

IRAVANI N. | Perastehnejad E. | Issue Writer Certificate

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Abstract

HETEROCYLIC COMPOUNDS ARE CONSIDERED AS THE MOST PROMISING MOLECULES FOR THE DESIGN OF NEW DRUG. PYRAZOLES ARE AN IMPORTANT CLASS OF BIO-ACTIVE DRUG TARGESTS IN THE PHARMACEUTICAL IN DUSTRY, AS THEY ARE THE CORE STRUCTURE OF NUMEROUS BIOLOGICALLY ACTIVE COMPOUNDS [1, 2]. PYRAZOLE DERIVATIVES ARE ASSOCIATED WITH WIDE SPECTRUM OF BIOLOGICAL ACTIVITIES SUCH AS ANALGESIC, ANTI- PYRETIC AND PLANT GROWTH REGULATING [3].SYNTHESIS OF 4, 4' (ARYLMETHYLENE) BIS (1H-PYRAZOL-5-OLS) HAS BEEN ACCOMPLISHED BY TANDEM KNOEVENAGEL-MICHAEL REACTION OF TWO EQUIVALENTS OF 3-METHYL-1-PHENYL-2-PYRAZOLINE-5-ON WITH VARIOUS AROMATIC ALDEHYDES CATALYZED BY PERCHLORATE SULFURIC ACID (PCSA) IN ETHANOL UNDER REFLUXING CONDITIONS WITH 80-93%YELID. (SCHEME 1).

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APA: Copy

IRAVANI, N., & Perastehnejad, E.. (2013). SYNTHESIS OF 4,4’-(ARYLMETHYLENE) BIS (1H-PYRAZOL-5-OLS) USING PERCHLORATE SULFURIC ACID(PCSA) AS CATALYST. IRANIAN CHEMISTRY CONGRESS. SID. https://sid.ir/paper/915433/en

Vancouver: Copy

IRAVANI N., Perastehnejad E.. SYNTHESIS OF 4,4’-(ARYLMETHYLENE) BIS (1H-PYRAZOL-5-OLS) USING PERCHLORATE SULFURIC ACID(PCSA) AS CATALYST. 2013. Available from: https://sid.ir/paper/915433/en

IEEE: Copy

N. IRAVANI, and E. Perastehnejad, “SYNTHESIS OF 4,4’-(ARYLMETHYLENE) BIS (1H-PYRAZOL-5-OLS) USING PERCHLORATE SULFURIC ACID(PCSA) AS CATALYST,” presented at the IRANIAN CHEMISTRY CONGRESS. 2013, [Online]. Available: https://sid.ir/paper/915433/en

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