EFFECT OF SALT ON RECOMBINANT INTERFERON BETA-1B FUNCTION

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MALAKIAN A.; ARDJMAND M.; FAZELI A.; SABERI M.

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Seminar Paper

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Seminar: CHEMICAL ENGINEERING CONGRESS AND EXHIBITION
Year:2014 | Issue:8

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Title

EFFECT OF SALT ON RECOMBINANT INTERFERON BETA-1B FUNCTION

Author(s)

MALAKIAN A. | ARDJMAND M. | FAZELI A. | SABERI M. | Issue Writer Certificate

Keywords

REFOLDING PROCESS

INTERFERON BETA-1B

SALT PRESENCE

NACL

NA2SO4

PROTEIN ACTIVITY

Abstract

PRODUCING RECOMBINANT PROTEINS IN E. COLI RESULTS IN FORMATION OF INCLUSION BODIES AND NEED TO REFOLD TO NATIVE STRUCTURE FOR NORMAL ACTIVITY. MANY FACTORS EFFECT ON PROTEIN REFOLDING. ONE OF THEM IS PRESENCE OF SALTS [6, 7]. THE EFFECT OF NACL AND NA2SO4 WITH CONCENTRATION VARIETY ON INTERFERON BETA-1B WAS INVESTIGATED TO OBSERVE CHANGING OF PROTEIN ACTIVITY. HIGH CONCENTRATION OF NA2SO4 HAS INHIBITORY EFFECTS DUE TO TWO POSITIVE CHARGE OF CATION, BUT CONCENTRATION OF NACL UP TO 1M DOES NOT HAVE INHIBITORY EFFECT ON THE ACTIVITY OF PROTEIN. THE AMOUNT OF 0.56M OF NACL AND 0.002M OF NA2SO4 WAS FOUND FOR MAXIMUM INTERFERON BETA-1B ACTIVITY.

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APA: Copy

MALAKIAN, A., ARDJMAND, M., FAZELI, A., & SABERI, M.. (2014). EFFECT OF SALT ON RECOMBINANT INTERFERON BETA-1B FUNCTION. INTERNATIONAL CHEMICAL ENGINEERING CONGRESS AND EXHIBITION. SID. https://sid.ir/paper/916360/en

Vancouver: Copy

MALAKIAN A., ARDJMAND M., FAZELI A., SABERI M.. EFFECT OF SALT ON RECOMBINANT INTERFERON BETA-1B FUNCTION. 2014. Available from: https://sid.ir/paper/916360/en

IEEE: Copy

A. MALAKIAN, M. ARDJMAND, A. FAZELI, and M. SABERI, “EFFECT OF SALT ON RECOMBINANT INTERFERON BETA-1B FUNCTION,” presented at the INTERNATIONAL CHEMICAL ENGINEERING CONGRESS AND EXHIBITION. 2014, [Online]. Available: https://sid.ir/paper/916360/en

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