GENES INVOLVING IMMUNOLOGICAL PATHWAY OF MULTIPLE SCLEROSIS

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DEHGHANI LEILA; SABBAGH SIMA

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Seminar Paper

Paper Information

Seminar: INTERNATIONAL MS CONGRESS OF IRAN
Year:2015 | Issue:12

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Title

GENES INVOLVING IMMUNOLOGICAL PATHWAY OF MULTIPLE SCLEROSIS

Author(s)

DEHGHANI LEILA | SABBAGH SIMA

Keywords

MULTIPLE SCLEROSIS

GENES

IMMUNE SYSTEM

Abstract

MULTIPLE SCLEROSIS (MS) IS A CHRONIC AUTOIMMUNE DEMYELINATING DISEASE OF THE CENTRAL NERVOUS SYSTEM (CNS) CHARACTERIZED BY INFLAMMATION, DEMYELINATION AND PRIMARY OR SECONDARY AXONAL DEGENERATION. AUTOIMMUNE DISEASES REVEAL TYPICAL CHARACTERISTICS OF COMMON COMPLEX DISEASES. THESE DISEASES ARE NON- MENDELIAN, BUT FREQUENTLY SHOW FAMILIAL CLUSTERING. RECENT DATA, HOWEVER, SUGGEST THAT THE PATHOGENESIS OF MULTIPLE SCLEROSIS IS MUCH MORE COMPLEX AND THAT AUTOIMMUNE MEDIATED INFLAMMATION MAY ONLY BE RESPONSIBLE FOR A PART OF THE DISEASE SPECTRUM. PREVIOUS STUDIES HAVE CONFIRMED THAT THE ONSET OF MS IS THE RESULT OF THE INTERPLAY OF ENVIRONMENTAL FACTORS AND GENETICS. THE GENETICS OF COMMON COMPLEX DISEASES, MANY OF WHICH ARE AUTOIMMUNE, ARE DIFFICULT TO UNDERSTAND. IT IS CLEAR THAT THE SUSCEPTIBILITY TO MS, RESULTS FROM INTERACTIONS OF GENES, ENVIRONMENTAL INTERACTIONS AND GENE/ENVIRONMENT INTERACTIONS...

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APA: Copy

DEHGHANI, LEILA, & SABBAGH, SIMA. (2015). GENES INVOLVING IMMUNOLOGICAL PATHWAY OF MULTIPLE SCLEROSIS. INTERNATIONAL MS CONGRESS OF IRAN. SID. https://sid.ir/paper/921100/en

Vancouver: Copy

DEHGHANI LEILA, SABBAGH SIMA. GENES INVOLVING IMMUNOLOGICAL PATHWAY OF MULTIPLE SCLEROSIS. 2015. Available from: https://sid.ir/paper/921100/en

IEEE: Copy

LEILA DEHGHANI, and SIMA SABBAGH, “GENES INVOLVING IMMUNOLOGICAL PATHWAY OF MULTIPLE SCLEROSIS,” presented at the INTERNATIONAL MS CONGRESS OF IRAN. 2015, [Online]. Available: https://sid.ir/paper/921100/en

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