ASSESSMENT OF GENETIC VARIATIONS IN EXON 4 OF RABL2B GENE IN INFERTILE MEN WITH OLIGOASTHENOTERATOSPERMIA

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HOSSEINI H.; MOHSENI MEYBODI A.; HOSSEINIFAR H.; SADIGHI GILANI M.A.; SABBAGHIAN M.

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Seminar Paper

Paper Information

Seminar: IRHRC ANNUAL MEETING REPRODUCTIVE AND INFERTILITY UPDATES
Year:2015 | Issue:7

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Title

ASSESSMENT OF GENETIC VARIATIONS IN EXON 4 OF RABL2B GENE IN INFERTILE MEN WITH OLIGOASTHENOTERATOSPERMIA

Author(s)

HOSSEINI H. | MOHSENI MEYBODI A. | HOSSEINIFAR H. | SADIGHI GILANI M.A. | SABBAGHIAN M.

Keywords

OLIGOASTHENOTERATOSPERMIA

RABL2B GENE

Abstract

DEFECT IN STRUCTURE AND FUNCTION OF SPERM IS ONE OF THE MAIN CAUSES OF MALE INFERTILITY. NORMAL SPERMATOZOA MUST HAVE APPROPRIATE MORPHOLOGY, MOTILITY AND COUNT ACCORDING TO THE WHO 2010 STANDARDS.OLIGOASTHENOTERATOSPERMIC MEN HAVE SPERMS WITH ABNORMALITIES IN COUNT, MOTILITY AND MORPHOLOGY THAT NOT ABLE TO FERTILIZE OOCYTE. SEVERAL GENES ARE INVOLVED IN THE FORMATION OF SPERM. ONE OF THESE GENES IS RAB LIKE2B (RABL2B) WHICH ITS ESSENTIAL ROLE IN SPERM INTRAFLAGELLAR TRANSPORT AND FERTILITY IN MOUSE HAS BEEN DEMONSTRATED. ACCORDINGLY IT IS AN APPROPRIATE CANDIDATE GENE IN HUMAN STUDIES. RABL2B IS A G PROTEIN AND HAVE 4 GTP BINDING DOMAINS THAT HAVE IMPORTANT ROLES IN PROTEIN FUNCTION. EXON 4 CODES ONE OF THESE DOMAINS….

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APA: Copy

HOSSEINI, H., MOHSENI MEYBODI, A., HOSSEINIFAR, H., SADIGHI GILANI, M.A., & SABBAGHIAN, M.. (2015). ASSESSMENT OF GENETIC VARIATIONS IN EXON 4 OF RABL2B GENE IN INFERTILE MEN WITH OLIGOASTHENOTERATOSPERMIA. IRHRC ANNUAL MEETING REPRODUCTIVE AND INFERTILITY UPDATES. SID. https://sid.ir/paper/924561/en

Vancouver: Copy

HOSSEINI H., MOHSENI MEYBODI A., HOSSEINIFAR H., SADIGHI GILANI M.A., SABBAGHIAN M.. ASSESSMENT OF GENETIC VARIATIONS IN EXON 4 OF RABL2B GENE IN INFERTILE MEN WITH OLIGOASTHENOTERATOSPERMIA. 2015. Available from: https://sid.ir/paper/924561/en

IEEE: Copy

H. HOSSEINI, A. MOHSENI MEYBODI, H. HOSSEINIFAR, M.A. SADIGHI GILANI, and M. SABBAGHIAN, “ASSESSMENT OF GENETIC VARIATIONS IN EXON 4 OF RABL2B GENE IN INFERTILE MEN WITH OLIGOASTHENOTERATOSPERMIA,” presented at the IRHRC ANNUAL MEETING REPRODUCTIVE AND INFERTILITY UPDATES. 2015, [Online]. Available: https://sid.ir/paper/924561/en

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