THE OPTIMIZATION OF THE RSAD2 SIRNA CONCENTRATION IN HUH-7 CELLS TREATED WITH INTERFERON ALPHA

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shirmast Paniz; MIRSHAHABI HESAM; AREFIAN EHSAN; HAGHI FAKHRI

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Seminar Paper

Paper Information

Seminar: CONFERENCE ON UPDATE MANAGEMENT OF HBV AND HCV
Year:2016 | Issue:37

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Title

THE OPTIMIZATION OF THE RSAD2 SIRNA CONCENTRATION IN HUH-7 CELLS TREATED WITH INTERFERON ALPHA

Author(s)

shirmast Paniz | MIRSHAHABI HESAM | AREFIAN EHSAN | HAGHI FAKHRI

Keywords

SIRNA

RSAD2

HBV

INTERFERON ALPHA

HCV

Abstract

BACKGROUND: SMALL INTERFERING RNAS (SIRNAS) HAVE BEEN USED AS A REMARKABLE TOOL FOR KNOCK DOWNING OF SPECIFIC GENES EXPRESSION IN EXPERIMENTAL STUDIES. RSAD2 (RADICAL SAM-DOMAIN-CONTAINING 2) BELONGS TO THE FAMILY OF INTERFERON STIMULATED GENES (ISG) WHICH IS HIGHLY INDUCED BY TYPE I, II, AND III INTERFERONS (IFN).INTERFERON ALPHA HAS BEEN APPROVED AS THE FIRST DRUG USED FOR TREATMENT OF VIRAL HEPATITIS INFECTION.RSAD2 GENE PLAYS A FUNDAMENTAL ROLE IN RESTRICTING REPLICATIONS OF DIFFERENT VIRUSES INCLUDING HCV AND ALSO MAY BE A KEY FACTOR DURING INFECTION OF HEPATITIS B VIRUS. THE AIM OF THIS STUDY WAS TO DETERMINE THE OPTIMAL CONCENTRATION OF SIRNA WHICH IS NEEDED FOR INHIBITION OF THE RSAD2 GENE EXPRESSION IN HUH-7 CELLS.

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APA: Copy

shirmast, Paniz, MIRSHAHABI, HESAM, AREFIAN, EHSAN, & HAGHI, FAKHRI. (2016). THE OPTIMIZATION OF THE RSAD2 SIRNA CONCENTRATION IN HUH-7 CELLS TREATED WITH INTERFERON ALPHA. CONFERENCE ON UPDATE MANAGEMENT OF HBV AND HCV. SID. https://sid.ir/paper/924748/en

Vancouver: Copy

shirmast Paniz, MIRSHAHABI HESAM, AREFIAN EHSAN, HAGHI FAKHRI. THE OPTIMIZATION OF THE RSAD2 SIRNA CONCENTRATION IN HUH-7 CELLS TREATED WITH INTERFERON ALPHA. 2016. Available from: https://sid.ir/paper/924748/en

IEEE: Copy

Paniz shirmast, HESAM MIRSHAHABI, EHSAN AREFIAN, and FAKHRI HAGHI, “THE OPTIMIZATION OF THE RSAD2 SIRNA CONCENTRATION IN HUH-7 CELLS TREATED WITH INTERFERON ALPHA,” presented at the CONFERENCE ON UPDATE MANAGEMENT OF HBV AND HCV. 2016, [Online]. Available: https://sid.ir/paper/924748/en

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