CONFERENCE ON UPDATE MANAGEMENT OF HBV AND HCV | Year:2016 | دوره:37 |Papers Count:12

BACKGROUND AND OBJECTIVE: INTERLEUKIN 10 (IL-10) IS A CYTOKINE WITH ANTI-INFLAMMATORY FUNCTIONS. THE RESULTS OF THE DIFFERENT STUDIES VARY IN THE ROLES OF THE IL-10 SNPS IN THE SUSCEPTIBILITY TO THE HEPATITIS B VIRUS INFECTION. IN PARTICULAR, THE -1082A/G, -819 C/T AND -592 A/C POLYMORPHISMS HAVE MOST OFTEN BEEN IMPLICATED. WE HAVE PERFORMED A METAANALYSIS INCLUDING 31 CASE-CONTROL STUDIES TO SUMMARIZE THE DATA ON THE ASSOCIATION BETWEEN IL-10 SNPS AND SUSCEPTIBILITY TO HBV INFECTION. THIS STUDY AIMED AT EVALUATING THE RELATIONSHIP BETWEEN POLYMORPHISMS IN THE IL-10 PROMOTER REGION AND HBV INFECTION…..

BACKGROUND AND AIM: GENETIC VARIANTS OF CHEMOKINE AND REGULATORY CYTOKINES PLAYFUNCTIONAL ROLES IN CHRONIC HBV INFECTION. THE OBJECTIVE OF THE STUDY, WAS TO EVALUATE THE ASSOCIATION BETWEEN THECCR5D32, CCR5-2459A/G, MCP1-2518A/G, VDR-APA1A/A, VDR-TAQ1T/T SNPSAND HBV SUSCEPTIBILITY, IN A SAMPLE OF IRANIAN….

BACKGROUND: SMALL INTERFERING RNAS (SIRNAS) HAVE BEEN USED AS A REMARKABLE TOOL FOR KNOCK DOWNING OF SPECIFIC GENES EXPRESSION IN EXPERIMENTAL STUDIES. RSAD2 (RADICAL SAM-DOMAIN-CONTAINING 2) BELONGS TO THE FAMILY OF INTERFERON STIMULATED GENES (ISG) WHICH IS HIGHLY INDUCED BY TYPE I, II, AND III INTERFERONS (IFN).INTERFERON ALPHA HAS BEEN APPROVED AS THE FIRST DRUG USED FOR TREATMENT OF VIRAL HEPATITIS INFECTION.RSAD2 GENE PLAYS A FUNDAMENTAL ROLE IN RESTRICTING REPLICATIONS OF DIFFERENT VIRUSES INCLUDING HCV AND ALSO MAY BE A KEY FACTOR DURING INFECTION OF HEPATITIS B VIRUS. THE AIM OF THIS STUDY WAS TO DETERMINE THE OPTIMAL CONCENTRATION OF SIRNA WHICH IS NEEDED FOR INHIBITION OF THE RSAD2 GENE EXPRESSION IN HUH-7 CELLS.

BACKGROUND AND AIM: SEVERAL HOST AND VIRAL FACTORS AFFECT THE NATURAL HISTORY OF HEPATITIS C VIRUS (HCV) INFECTION. INTERLUKINE 32 (IL-32), A PROINFLAMMATORY CYTOKINE, IS INCREASINGLY RECOGNIZED TO BE AN IMPORTANT HOST-PROTECTIVE MOLECULE AGAINST INFECTIOUS DISEASES. THIS STUDY AIMED TO EVALUATE ANY ASSOCIATION BETWEEN IL-32 POLYMORPHISM AND HCV INFECTION AND ITS EFFECT ON VIRAL CLEARANCE.METHODS: IN A POPULATION-BASED STUDY OF 60 HCV PATIENTS AND 75 HEALTHY CONTROLS, IL-32 POLYMORPHISM WAS DETERMINED BY RFLP-PCR. THE MEAN AGE OF THE PATIENTS AND CONTROLS WAS 38.32 ± 10.31 AND 40.92 ± 3.026, RESPECTIVELY. ANY ASSOCIATION OF IL-32 T/C POLYMORPHISM WITH VIRAL CLEARANCE WAS ALSO DETERMINED….

OBJECTIVE: TO DETERMINE THE PATTERNS OF DISTRIBUTION OF HCV GENOTYPES AMONG HIGH RISK POPULATION IN NORTH OF IRAN.METHODS: A CROSS-SECTIONAL STUDY WAS CONDUCTED ON 135 HCV RNAPOSITIVE HIGH RISK INDIVIDUALS INCLUDING THALASSEMIA, HEMOPHILIA, PATIENTS UNDER HEMODIALYSIS AND INTRAVENOUS DRUG ADDICTS. HCV GENOTYPES WERE DETERMINED BASED ON AMPLIFICATION WITH TYPE-SPECIFIC PRIMERS METHODS….

BACKGROUND: HEPATITIS C VIRUS (HCV) INFECTION IS A MAJOR PUBLIC HEALTH CONCERN AND THE THIRD MOST COMMON CAUSE OF DEATH FROM CANCER, WORLDWIDE. THIS INFECTION IS THE MOST COMMON RISK FACTOR FOR THE PROGRESSION OF CHRONIC LIVER DISEASE, CHRONIC HEPATITIS, CIRRHOSIS, AND HEPATOCELLULAR CARCINOMA. HCV INFECTION HAS BEEN CLASSIFIED INTO SIX MAJOR GENOTYPES AND MULTIPLE SUBTYPES. THE DISTRIBUTION OF HCV GENOTYPES SEEMS TO VARY IN DIFFERENT AREAS AROUND THE WORLD….

BACKGROUND AND AIM: SURVIVIN CAN AFFECT THE PROGRESSION OF INFECTION AND IS CONSIDERED AS A MARKER OF VARIOUS MALIGNANCIES. THE AIM OF THE STUDY WASTO INVESTIGATE THE POSSIBLE ASSOCIATION OF GENE POLYMORPHISMS OF SURVIVING (1547A/G, -644C/T, -625 C/G, -241C/T, -31G/C, -141G/C) AND CHRONIC HEPATITIS B INFECTION IN IRANIAN PATIENTS….

BACKGROUND: HEPATITIS B VIRUS (HBV) INFECTION REMAINS A MAJOR HEALTH BURDEN WORLD-WIDE IN 5% OF HUMAN POPULATION THAT ARE CHRONIC CARRIERS OF HBV. VACCINATION IS A WELLESTABLISHED, SAFE AND EFFECTIVE METHOD OF CONFERRING LONG-TERM PROTECTION AGAINST HEPATITIS B VIRAL INFECTIONS GLOBAL, HOWEVER THE IMMUNE RESPONSE TO HBV VACCINE IS SIGNIFICANTLY DIFFERENT AMONG INDIVIDUALS AND 5-10% OF HEALTHY ADULTS FAIL TO PRODUCE PROTECTING LEVELS OF ANTIBODIES AGAINST THE HEPATITIS B SURFACE ANTIGEN (ANTI-HBS) CONTAINED IN THE VACCINE.THEREFORE, THE AIM OF THIS STUDY IS TO ASSESS THE FACTORS AFFECT ON INDIVIDUALS THAT NONRESPONSE TO HBV VACCINE….

BACKGROUND AND OBJECTIVE: HEPATITIS B VIRUS (HBV) INFECTION CAN RESULT IN A NUMBER OF DIFFERENT CLINICAL CONDITIONS. VARIATIONS IN CYTOKINE GENES HAVE BEEN DISCUSSED TO AFFECT THE NATURAL HISTORY OF HBV INFECTION. VARIOUS STUDIES REVEAL THAT SNPS PLAY AN IMPORTANT ROLE IN PATHOGENESIS OF HBV. ON THE OTHER HAND, VARIOUS OUTCOMES OF INFECTION CANNOT BE COMPLETELY SHOWN BY GENETIC FACTORS BECAUSE THESE STUDIES HAVE INCONSISTENT RESULTS WITH REGARD TO THE POSSIBLE IMPACTS OF HOST GENETIC POLYMORPHISMS ON SUSCEPTIBILITY TO INFECTION.THEREFORE, TO IDENTIFY THE REAL EFFECTS OF HOST GENETIC FACTORS IN HBV SUSCEPTIBILITY AND NATURAL HISTORY OF THE DISEASE, STUDIES WITH LARGE SAMPLE SIZE WILL BE NEEDED. IN ADDITION, DUE TO THE COMPLEX INTERACTIONS OF GENETIC IT IS BETTER TO IDENTIFY SYNERGIES OF SEVERAL SNPS.SUCH STUDIES CAN PROVIDE BETTER INSIGHTS INTO THE NOVEL METHODS OF DIAGNOSIS AND TREATMENT.SEARCH METHOD: HOST IMMUNITY AND GENETIC FACTORS PLAY IMPORTANT ROLES DURING INFECTIONS.CURRENT REVIEW WILL DISCUSS SIGNIFICANT GENETIC VARIATIONS IN CYTOKINE GENES THAT MAY AFFECT THE SUSCEPTIBILITY TO THE CHRONIC HBV INFECTION. THE AIM OF OUR RESEARCH IS TO PROVIDE DIAGNOSTIC MARKERS FOR THE SUSCEPTIBILITY TO HBV INFECTION….

BACKGROUND AND AIM: THE HOST GENETIC BACKGROUND REGULATES THE NATURAL HISTORY OF CHRONIC HBV INFECTION. THE AIM OF THIS STUDY WAS TO INVESTIGATE THE ASSOCIATION BETWEEN TNF-A GENE POLYMORPHISM IN THE PROMOTER REGION WITH SUSCEPTIBILITY TO CHRONIC HEPATITIS B VIRUS INFECTION….

INTRODUCTION: KNOWLEDGE AND ATTITUDES OF SOCIETY PLAY AN IMPORTANT ROLE IN REDUCING THE PREVALENCE AND INCIDENCE OF HEPATITIS B DISEASE. HEPATITIS IS A GENERAL TERM FOR INFLAMMATION OF THE LIVER THAT CAUSED BY VARIOUS REASONS, SUCH AS MEDICATION, A VIRUS AND ETC. HEPATITIS IS A VIRAL INFECTION AND SYSTEMIC THAT INFECTS THE LIVER AND HAVE ABILITY TO BE BLOOD TRANSMITTED FROM ONE PERSON TO ANOTHER. INCREASE KNOWLEDGE AND ATTITUDE OF STUDENTS ABOUT THE PREVENTION OF THIS KIND OF DISEASE SEEMS ESSENTIAL. THAT IS WHY THIS STUDY AIMED TO DETERMINE THE KNOWLEDGE OF PARAMEDICAL STUDENTS OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES ABOUT HEPATITIS B. BECAUSE FIELDS OF THIS FACULTY LIKE MEDICAL LABORATORY SCIENCES ARE IN HIGH RISK OF DEVELOPING THIS DISEASE BY DEALING WITH BLOOD PRODUCTS….

HEPATITIS C VIRUS (HCV) IS ONE OF THE MOST ENDEMIC VIRAL PATHOGEN THAT CURRENTLY INFECTS MORE THAN 170 MILLION PEOPLE WORLDWIDE. HCV CAUSES ACUTE AND CHRONIC HEPATITIS THAT PROGRESS TO LIVER CIRRHOSIS OR HEPATOCELLULAR CARCINOMA. HCV PATIENTS HAVE TWO POSSIBLE OUTCOMES OF INFECTION, CLEARANCE OR PERSISTENT INFECTION. APPROXIMATELY 20 % OF PRIMARY HCV INFECTED-PEOPLE SUCCESSFULLY CLEAR THE HCV, WHILE THE REMAINING 80 % OF CASES FAIL TO DO SO. THE INTERACTION BETWEEN HOST AND HCV VIRAL COMPONENTS ULTIMATELY DETERMINES THE BALANCE BETWEEN THE VIRUS AND HOST. HOST FACTORS, SUCH AS GENETIC BACKGROUND OR IMMUNE RESPONSIVENESS, DICTATE THE DISTINCT OUTCOMES. VIRAL INFECTION OF A CELL ACTIVATES A PANEL OF PATTERN RECOGNITION RECEPTORS THAT MEDIATE ANTIVIRAL INNATE AND ADAPTIVE HOST IMMUNE RESPONSES TO INHIBIT VIRAL REPLICATION AND DISSEMINATION. HOWEVER, HCV UTILIZES MULTIFACETED STRATEGIES TO EVADE OR SUBVERT THE HOST IMMUNE RESPONSES….