DIRECTED TRANSFORM FUNCTION APPROACH FOR FUNCTIONALNETWORK ANALYSIS IN RESTING STATE FMRI DATA OFPARKINSON DISEASE

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GHASEMI MAHDIEH; Mahloojifar ali

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Seminar Paper

Paper Information

Seminar: IRANIAN CONFERENCE ON BIOMEDICAL ENGINEERING
Year:2012 | Issue:19

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Title

DIRECTED TRANSFORM FUNCTION APPROACH FOR FUNCTIONALNETWORK ANALYSIS IN RESTING STATE FMRI DATA OFPARKINSON DISEASE

Author(s)

GHASEMI MAHDIEH | Mahloojifar ali

Keywords

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Abstract

PARKINSON'S DISEASE (PD) IS A PROGRESSIVE NEUROLOGICAL DISORDER CHARACTERIZED BY TREMOR, RIGIDITY, AND SLOWNESS OF MOVEMENTS. SPECIFIC CHANGES ASSOCIATED WITH VARIOUS PATHOLOGICAL ATTACKS IN PARKINSON DISEASE CAN BE INDICATES IN DIRECTIONAL INTERACTION OF THE BRAIN NETWORK FROM RESTING STATE FMRI DATA. FOR CONSTRUCTING THE DIRECTIONAL BRAIN NETWORK FROM SPONTANEOUS ACTIVITY IN RESTING STATE, WE USED DIRECTED TRANSFORM FUNCTION (DTF) APPROACH COMBINING WITH GRAPH THEORY. THE PROPOSED METHOD APPLIED ON EACH PAIR OF REFERENCE TIME SERIES OF THE SELECTED REGIONS IN THE FREQUENCY DOMAIN. FURTHERMORE, TOPOLOGICAL PARAMETERS LIKE DEGREE OF A GIVEN NODE WERE CALCULATED FOR GRAPHS IN THREE FREQUENCY BANDWIDTHS. MINIMUM SIGNIFICANT CONNECTIONS OF BETWEEN GROUP ANALYSIS IN THE UPPER FREQUENCY BANDWIDTH DEPICTED THAT THERE ARE COMMON INFLUENCE INFORMATION IN UPPER BAND BETWEEN PD AND HEALTHY. MOREOVER, INTER-GROUP COMPARISON ANALYSIS OF RESTING STATE SHOWS THAT EFFECTIVE INTERACTIONS IN PD ARE STRONGER THAN HEALTHY. FURTHERMORE, SOME BRAIN REGIONS SUCH AS LEFT THALAMUS HAS THE MOST INFORMATION FLOW IN PD WHICH CHARACTERIZED BY PIVOTAL REGIONS WHICH WERE INFLUENCED BY THE OTHER BRAIN REGIONS. WE FOUND THAT DTF ANALYSIS IN FREQUENCY DOMAIN COMBINED WITH GRAPH STRUCTURECOULD POTENTIALLY PROVIDE INFORMATION ON DIRECTIONAL INTERACTIONS WITHIN REGIONS.

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APA: Copy

GHASEMI, MAHDIEH, & Mahloojifar, ali. (2012). DIRECTED TRANSFORM FUNCTION APPROACH FOR FUNCTIONALNETWORK ANALYSIS IN RESTING STATE FMRI DATA OFPARKINSON DISEASE. IRANIAN CONFERENCE ON BIOMEDICAL ENGINEERING. SID. https://sid.ir/paper/926375/en

Vancouver: Copy

GHASEMI MAHDIEH, Mahloojifar ali. DIRECTED TRANSFORM FUNCTION APPROACH FOR FUNCTIONALNETWORK ANALYSIS IN RESTING STATE FMRI DATA OFPARKINSON DISEASE. 2012. Available from: https://sid.ir/paper/926375/en

IEEE: Copy

MAHDIEH GHASEMI, and ali Mahloojifar, “DIRECTED TRANSFORM FUNCTION APPROACH FOR FUNCTIONALNETWORK ANALYSIS IN RESTING STATE FMRI DATA OFPARKINSON DISEASE,” presented at the IRANIAN CONFERENCE ON BIOMEDICAL ENGINEERING. 2012, [Online]. Available: https://sid.ir/paper/926375/en

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