THE NOVEL MITOCHONDRIAL HETEROPLASMIC MUTATION (M.9140 C>G) IN AN IRANIAN FAMILY WITH LONG QTS (LQT3)

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HEIDARI MOHAMMAD MEHDI; KHATAMI MEHRI

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Seminar Paper

Paper Information

Seminar: INTERNATIONAL IRANIAN BIOLOGY CONFERENCE
Year:2012 | Issue:17

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Title

THE NOVEL MITOCHONDRIAL HETEROPLASMIC MUTATION (M.9140 C>G) IN AN IRANIAN FAMILY WITH LONG QTS (LQT3)

Author(s)

HEIDARI MOHAMMAD MEHDI | KHATAMI MEHRI

Keywords

ARRHYTHMIA

LONG QT SYNDROME

MITOCHONDRIAL DNA

MUTATION

SSCP

Abstract

MITOCHONDRIAL DNA (MTDNA) COULD BE CONSIDERED A CANDIDATE MODIFIER FACTOR FOR SYNDROME OF LONG QT (LQTS), SINCE MITOCHONDRIAL OXIDATIVE STRESS IS THOUGHT TO BE INVOLVED IN ATP PRODUCTION. IT HAS BEEN REPORTED THAT THE ACTIVITY OF ION CHANNELS IN CARDIOMYOCYTES IS SENSITIVE TO ATP LEVEL. WE SEARCHED 40% OF THE ENTIRE MITOCHONDRIAL GENOME IN AN IRANIAN FAMILY WITH LQT3 FOR MUTATION BY PCR-SSCP AND DNA SEQUENCING. WE REPORT FOUR NEW MUTATIONS AND ONE REPORTED MUTATION, LEADING TO AN AMINO ACID SUBSTITUTION AND TWO MUTATIONS IN MITOCHONDRIAL TRNA. WE FOUND STATISTICALLY SIGNIFICANT CORRELATION (R=0.737) BETWEEN QTC (MS) AND AGE OF LQTS PATIENTS. OUR DATA SUGGEST THAT THESE MITOCHONDRIAL MUTATIONS IN A FAMILY WITH LQTS MIGHT BE RESPONSIBLE MITOCHONDRIAL DEFECTS AND INCREASE THE GRAVITY OF SYNDROME OF LONG QT (LQTS).

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APA: Copy

HEIDARI, MOHAMMAD MEHDI, & KHATAMI, MEHRI. (2012). THE NOVEL MITOCHONDRIAL HETEROPLASMIC MUTATION (M.9140 C>G) IN AN IRANIAN FAMILY WITH LONG QTS (LQT3). INTERNATIONAL IRANIAN BIOLOGY CONFERENCE. SID. https://sid.ir/paper/929066/en

Vancouver: Copy

HEIDARI MOHAMMAD MEHDI, KHATAMI MEHRI. THE NOVEL MITOCHONDRIAL HETEROPLASMIC MUTATION (M.9140 C>G) IN AN IRANIAN FAMILY WITH LONG QTS (LQT3). 2012. Available from: https://sid.ir/paper/929066/en

IEEE: Copy

MOHAMMAD MEHDI HEIDARI, and MEHRI KHATAMI, “THE NOVEL MITOCHONDRIAL HETEROPLASMIC MUTATION (M.9140 C>G) IN AN IRANIAN FAMILY WITH LONG QTS (LQT3),” presented at the INTERNATIONAL IRANIAN BIOLOGY CONFERENCE. 2012, [Online]. Available: https://sid.ir/paper/929066/en

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