GASTROINTESTINAL STEM CELLS AND CANCER BRIDGING THE MOLECULAR GAP

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Karimi Rokn Abadi Mohammad; zare Farshad; Tavakoli Sanaz; ASADI PARISA

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Seminar Paper

Paper Information

Seminar: INTERNATIONAL GASTROINTESTINAL CANCER CONGRESS
Year:2016 | Issue:3

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Title

GASTROINTESTINAL STEM CELLS AND CANCER BRIDGING THE MOLECULAR GAP

Author(s)

Karimi Rokn Abadi Mohammad | zare Farshad | Tavakoli Sanaz | ASADI PARISA

Keywords

APC

STEM CELLS

CLONALITY

NICHE SUCCESSION

CRYPT FISSION

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BOTTOM UP

Abstract

CANCER IS BELIEVED TO BE A DISEASE INVOLVING STEM CELLS. THE DIGESTIVE TRACT HAS A VERY HIGH CANCER PREVALENCE PARTLY OWING TO RAPID EPITHELIAL CELL TURNOVER AND EXPOSURE TO DIETARY TOXINS. WORK ON THE HEREDITARY CANCER SYNDROMES INCLUDING FAMALIAL ADENOMATOUS POLYPOSIS (FAP) HAS LED TO SIGNIFICANT ADVANCES, INCLUDING THE ADENOMACARCINOMA SEQUENCE. THE INITIAL MUTATION INVOLVED IN THIS STEPWISE PROGRESSION IS IN THE “GATEKEEPER” TUMOR SUPPRESSOR GENE ADENOMATOUS POLYPOSIS COLI (APC). IN FAP SOMATIC, SECOND HITS IN THIS GENE ARE NONRANDOM EVENTS, SELECTED FOR BY THE POSITION OF THE GERMLINE MUTATION...

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APA: Copy

Karimi Rokn Abadi, Mohammad, zare, Farshad, Tavakoli, Sanaz, & ASADI, PARISA. (2016). GASTROINTESTINAL STEM CELLS AND CANCER BRIDGING THE MOLECULAR GAP. INTERNATIONAL GASTROINTESTINAL CANCER CONGRESS. SID. https://sid.ir/paper/935670/en

Vancouver: Copy

Karimi Rokn Abadi Mohammad, zare Farshad, Tavakoli Sanaz, ASADI PARISA. GASTROINTESTINAL STEM CELLS AND CANCER BRIDGING THE MOLECULAR GAP. 2016. Available from: https://sid.ir/paper/935670/en

IEEE: Copy

Mohammad Karimi Rokn Abadi, Farshad zare, Sanaz Tavakoli, and PARISA ASADI, “GASTROINTESTINAL STEM CELLS AND CANCER BRIDGING THE MOLECULAR GAP,” presented at the INTERNATIONAL GASTROINTESTINAL CANCER CONGRESS. 2016, [Online]. Available: https://sid.ir/paper/935670/en

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