INTERNATIONAL GASTROINTESTINAL CANCER CONGRESS | Year:2016 | دوره:3 |Papers Count:122

INTRODUCTION & AIM: VENIPUNCTURE IN GASTROINTESTINAL CANCER PATIENTS IS VERY DIFFICULT AND PAINFUL BECAUSE OF USING CHEMOTHERAPY DRUGS. THEREFORE, THIS STUDY AIMED TO COMPARE THE EFFECT OF CARDAMOM AROMA AND MUSIC THERAPY ON VENIPUNCTURE PAIN IN PATIENTS WITH GASTROINTESTINAL CANCER...

INTRODUCTION & AIM: TGIF2LX (TRANSFORMING GROWTH FACTOR BETA-INDUCED FACTOR 2 LIKE, X-LINKED) IS A HOMEODOMAIN (HD) PROTEIN THAT HAS BEEN IMPLICATED IN THE NEGATIVE REGULATION OF CELL SIGNALING PATHWAYS. THE AIM OF THIS STUDY WAS TO INVESTIGATE THE POSSIBLE FUNCTIONS OF TGIF2LX IN COLON ADENOCARCINOMA...

INTRODUCTION: THE AIM OF THE STUDY IS TO ASCERTAIN HER2 POSITIVITY IN GASTRIC CANCER WITCH OPERATED IN OUR CENTER AND TO EVALUATE ITS CORRELATION WITH STAGING AND RESPONSE TO TREATMENT...

INTRODUCTION: GASTRIC CANCER IS THE MOST COMMON CANCERS IN THE WORLD. IT IS THE FOURTH MOST COMMON CANCER AND THE SECOND LEADING CAUSE OF CANCER DEATHS WORLDWIDE. THE SURVIVIN GENE WHICH ENCODES AN APOPTOSIS PROTEIN INHIBITOR PLAYS AN IMPORTANT ROLE IN MAINTENANCE AND INTEGRITY OF THE GASTRIC MUCOSA. THE GENE IS NECESSARY FOR THE NORMAL PHYSIOLOGIC FUNCTION OF THE STOMACH, BUT ITS EXPRESSION INCREASES IN GASTRIC CANCER.

INTRODUCTION: PEDIATRIC ONCOLOGY PATIENTS DEVELOPED SIMILAR ABDOMINAL EMERGENCIES AS IMMUNOCOMPETENT CHILDREN IN ADDITION TO ACUTE ABDOMEN FROM MALIGNANCY OR SECONDARY TREATMENT. CYTOTOXIC CHEMOTHERAPY, RADIOTHERAPY AND EXTENSIVE SURGICAL RESECTION ALL CONTRIBUTE TO THE RISK OF GASTROINTESTINAL SYMPTOMS. IMMUNOCOMPROMISED CHILDREN MAY LACK THE INFLAMMATORY SIGNS OF ACUTE ABDOMEN MAKING PROMPT DIAGNOSIS OF PEDIATRIC ONCOLOGIC ABDOMINAL EMERGENCIES CHALLENGING...

INTRODUCTION: OVARIAN EPITHELIAL CARCINOMA IS ONE OF THE MOST COMMON GYNECOLOGICAL CANCERS AND COLORECTAL CANCER IS THE FOURTH MOST COMMON CANCER IN MEN AND THE THIRD MOST COMMON IN WOMEN. HEREIN, WE REPORT A PATIENT WHO PRESENTED WITH AN ADENOCARCINOMA OF THE COLON OF FOURTEEN YEARS AFTER AN OVARIAN ADENOCARCINOMA...

BACKGROUND AND AIM: THE HYPOTHESIS THAT NON-SECRETOR STATUS OF INDIVIDUALS MAKES THEM MORE SUSCEPTIBLE TO CERTAIN BACTERIAL INFECTIONS AND THEY MIGHT BE AT A GREATER RISK OF METABOLIC SYNDROMES AND AUTOIMMUNE DISEASES MOTIVATED US TO EVALUATE THE RELATIONSHIP BETWEEN SECRETOR STATUS AND RISK FACTORS FOR DUODENAL ULCER IN THE PRESENT STUDY...

INTRODUCTION AND AIM: SOLUBLE FACTORS, CHEMOKINES AND CYTOKINES OF TUMOR CELLS LEAD TO INFLAMMATION, AND THE CELLS RECRUITED TO THE TUMOR MICROENVIRONMENT ARE MACROPHAGE AND MAST CELLS. STUDIES INDICATE THAT INFLAMMATION ACCELERATES TUMOR PROGRESSION. ON THE OTHER HAND, IMMUNE CELLS CAN ALSO INCREASE ANTI-TUMOR IMMUNITY. EXISTENCE OF THE IMMUNE CELLS AND SOLUBLE FACTORS MAINTAIN A BALANCE BETWEEN TUMOR PROMOTING INFLAMMATION AND ANTI-TUMOR IMMUNITY. MACROPHAGE INFILTRATION HAS BEEN ASSOCIATED WITH POOR PROGNOSIS IN DIFFERENT CANCERS, SUCH AS BREAST CANCER, AND CERVICAL CANCER. BUT AT THE INVASIVE STAGES OF COLORECTAL CANCER, IT WAS ASSOCIATED WITH IMPROVED PROGNOSIS. IN THIS STUDY, EFFECT OF COLORECTAL CANCER STEM CELL (HT-29) IN AN IMMUNE RESPONSE PRODUCED BY PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMNCS) WAS EVALUATED...

INTRODUCTION: NATURAL PRODUCTS ISOLATED FROM MARINE ENVIRONMENT ARE WELL KNOWN FOR THEIR PHARMACO-DYNAMIC POTENTIAL IN DIVERSITY OF DISEASE TREATMENTS SUCH AS CANCER OR INFLAMMATORY CONDITIONS. SEA CUCUMBERS ARE ONE OF THE MARINE ANIMALS OF THE PHYLUM ECHINODERM AND THE CLASS HOLOTHUROIDEA, WITH A LEATHERY SKIN AND GELATINOUS BODY. MANY STUDIES HAVE SHOWN THAT THE SEA CUCUMBER AND SPONGE CONTAINS ANTIOXIDANTS AND ANTI-CANCER COMPOUNDS. THIS STUDY WAS DESIGNED TO FIGURE OUT THE SELECTIVE TOXICITY OF PERSIAN GULF SEA CUCUMBER (HOLOTHURIA PARVA) METHANOLIC EXTRACT ON LIVER MITOCHONDRIA ISOLATED FROM ANIMAL MODEL OF HEPATOCELLULAR CARCINOMA AS PART OF A NATIONAL PROJECT WHICH HOPES TO COME ACROSS NOVEL POTENTIAL ANTICANCER CANDIDATES IN IRANIAN PERSIAN GULF FLORA AND FAUNA...

INTRODUCTION: STATISTICS SHOW THAT CANCER INCLUDING THREE LEADING CAUSES OF DEATH IN THE WORLD AND IN TERMS OF EPIDEMIOLOGY, DUE TO VARIOUS FACTORS INVOLVED ARE COMPLICATED. THE INCIDENCE OF THE DIFFERENT HISTOLOGICAL TYPES OF CANCER VARIES GREATLY BETWEEN VARIOUS POPULATIONS AND IS ATTRIBUTED TO OCCUPATIONAL, SOCIAL, CULTURAL, RACIAL (POSSIBLY HEREDITARY), AND GEOGRAPHIC INFLUENCES...

INTRODUCTION AND AIM: RECENTLY NANOPARTICLES HAVE SHOWN GREAT POTENTIAL TO BE USED IN DIAGNOSTIC AND THERAPEUTIC APPLICATIONS IN NUCLEAR MEDICINE. CHITOSAN NANOPARTICLES HAVE GAINED MORE ATTENTION AS DRUG DELIVERY CARRIERS BECAUSE OF THEIR BETTER STABILITY, LOW TOXICITY, SIMPLE AND MILD PREPARATION METHOD. DUE TO EXCELLENT BIOCOMPATIBILITY AND BIODEGRADABILITY OF CHITOSAN, HAVE BEEN USED EXTENSIVELY FOR PHARMACEUTICAL APPLICATION AND RADIOPHARMACEUTICAL IN NUCLEAR MEDICINE...

INTRODUCTION & AIM: THE FLUOROPYRIMIDINE DRUG 5-FLUOROURACIL (5-FU) AND THE PRODRUG CAPECITABINE, HAVE BEEN EXTENSIVELY USED FOR TREATMENT OF MANY TYPES OF CANCER INCLUDING COLORECTAL, GASTRIC AND HEAD AND NECK. APPROXIMATELY 10% OF THE PATIENTS SUFFER FROM SEVERE FLUOROPYRIMIDINE-INDUCED TOXICITY, LIKE DIARRHEA, MUCOSITIS, MYELOSUPPRESSION AND HAND-FOOT SYNDROME. THIS MAY LEAD TO DOSE REDUCTION AND TREATMENT DISCONTINUATION. PHARMACOGENETICS RESEARCH COULD BE USEFUL FOR IDENTIFICATION OF PREDICTIVE MARKERS IN CHEMOTHERAPY TREATMENT...

INTRODUCTION & AIM: ESOPHAGEAL CANCER IS A DANGEROUS AND FATAL DISEASE THAT A HIGH PERCENTAGE OF CANCER-RELATED MORTALITY STATISTICS HAS BEEN ALLOCATED TO THIS CANCER.NOWADAYS, THERE ARE MANY METHODS FOR TREATMENT OF ESOPHAGEAL CANCER, ALTHOUGH AN EXCESS NUMBER OF THE PATIENTS SUFFERING FROM THE POSTOPERATIVE CONVALESCENCE, RECURRENCE, AND METASTASIS OF THIS CANCER. THERE IS AN ENDLESS NEED FOR PICKING UP OUR UNDERSTANDING OF THE MOLECULAR BASIS OF THIS DISEASE. ONCOGENE OVEREXPRESSION OF HMGA2 GENE IS THE CAUSE OF TUMOR DEVELOPMENT IN CANCERS SUCH AS COLORECTAL, LUNG, PANCREAS, THYROID AND PROSTATE...

INTRODUCTION & AIM: EPIGENETIC ABNORMALITIES, INCLUDING CHANGES IN DNA METHYLATION, HAVE BEEN OBSERVED IN MANY TYPES OF CANCER, INCLUDING COLORECTAL CANCER (CRC). COLORECTAL CANCER IS THE THIRD MOST COMMON CANCER AND THE FOURTH LEADING CAUSE OF DEATH IN THE WORLD. TUMOR SUPPRESSOR EYA4 GENE THAT ACTS BY INDUCING UPREGULATION OF DKK1 AND INHIBITING THE WNT SIGNALING PATHWAY THAT WNT SIGNALING PLAYS AN IMPORTANT ROLE IN CRC CARCINOGENESIS...

YTTRIUM-90 (90Y) RADIOEMBOLISATION (RE) IS INCREASINGLY USED FOR THE TREATMENT OF PATIENTS WITH UNRESECTABLE PRIMARY OR METASTATIC LIVER TUMOURS. IMAGE-BASED APPROACHES TO ASSESS MICROSPHERE DISTRIBUTION AFTER RE HAVE GAINED INTEREST BUT ARE MOSTLY HAMPERED BY THE LIMITED IMAGING POSSIBILITIES OF THE ISOTOPE 90Y...

INTRODUCTION: COLORECTAL CANCER IS ONE OF THE MOST COMMON GASTROINTESTINAL CANCER, ABOUT 10 PERCENT OF CANCER DEATHS ACCOUNTED FOR. COLORECTAL CANCER IS THE FIFTH MOST COMMON CANCER IN WOMEN BRAS AND IRANIAN MEN TAKEN INTO ACCOUNT. THE CLOSE ASSOCIATION BETWEEN COLORECTAL CANCER AND LIFESTYLE AND EATING BEHAVIORS SHOWN. SO THAT PROPER NUTRITION CAN PREVENT MORE THAN 50% OF THE CASES CAN BE PREVENTED. THIS STUDY AIMED TO REVIEW THE RELATIONSHIP BETWEEN NUTRITIONAL FACTORS AND COLORECTAL CANCER...

INTRODUCTION AND AIM: DAILY SETUP ERRORS AND CHANGES IN BODY HABITUS DURING EXTERNAL BEAM RADIOTHERAPY CAN RESULT IN INTERFRACTION VARIATION, CONTRIBUTING TO UNCERTAINTIES IN TREATMENT DELIVERY. THE CONVENTIONAL METHOD OF PATIENT POSITIONING USING EXTERNAL SKIN MARKINGS IS INADEQUATE IN REDUCING THESE INTERFRACTION VARIATIONS.TO EVALUATE USE OF ON-BOARD IMAGING WITH DAILY KV-KV IMAGE MATCHING TO REDUCE INTERFRACTION VARIATION IN PATIENTS WITH PRIMARY GASTROINTESTINAL CANCER...

PURPOSE/ OBJECTIVES: UROLOGICAL AND SEXUAL DYSFUNCTION ARE RECOGNISED RISKS OF RECTAL CANCER SURGERY, HOWEVER, THERE IS LIMITED EVIDENCE REGARDING UROGENITAL FUNCTION COMPARING ROBOTIC TO LAPAROSCOPIC APPROACH. THE AIM OF THIS STUDY WAS TO ASSESS THE UROLOGICAL AND SEXUAL OUTCOMES OF PATIENTS UNDERGOING LAPAROSCOPIC AND ROBOTIC RECTAL CANCER SURGERY...

INTRODUCTION & AIM: COLORECTAL CANCER IS THE DEVELOPMENT OF CANCER FROM THE COLON OR RECTUM THAT HAVE THE ABILITY TO INVADE OR SPREAD TO OTHER PARTS OF THE BODY.COLORECTAL CANCER IS A MAJOR WORLDWIDE HEALTH PROBLEM OWING TO ITS HIGH PREVALENCE AND MORTALITY RATES. THE CUCURBITACINS ARE A GROUP OF TETRACYCLIC TRITERPENOIDS DERIVED FROM THE CUCURBITANE SKELETON AND FOUND PRIMARILY IN THE CUCURBITACEAE FAMILY. A FACT WHICH HAS GIVEN RISE TO SEVERAL STUDIES CONCERNING THEIR POTENTIAL USE AS ANTIINFLAMMATORY AND ANTICANCER AGENTS...

INTRODUCTION & AIM: GASTRIC CANCER IS AMONG THE LEADING CAUSES OF CANCER-RELATED DEATH, AND THE SYMPTOMS ARE COMMONLY CHARACTERIZED IN ADVANCED STAGES. HISTONE ACETYLATION IS AMONG THE MOST IMPORTANT EPIGENETIC ALTERATIONS OCCURRING DURING CANCER DEVELOPMENT. IN ADDITION, REDUCED E-CADHERIN EXPRESSION IS A MAJOR CONTRIBUTOR IN THE PROCESS OF TUMOR CELL INVASION AND METASTASIS. OXAMFLATIN IS A HISTONE DEACETYLASE INHIBITOR THAT HAS BEEN SUGGESTED AS A PROMISING ANTI-TUMOR AGENT; YET ITS EFFECT ON THE VIABILITY AND INVASION OF GASTRIC TUMOR CELLS IS UNCLEAR. WE AIMED TO ASSESS THE IMPACT OF OXAMFLATIN ON THE VIABILITY OF GASTRIC TUMOR CELLS AND EXPRESSION OF E-CADHERIN AS A MARKER OF TUMOR INVASION SUSCEPTIBILITY...

INTRODUCTION & AIM: COLORECTAL CANCER (CRC) IS ONE OF THE MOST COMMON TYPES OF CANCERS IN THE WORLD. VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) HAS AN ESSENTIAL ROLE IN TUMOR ANGIOGENESIS AND INVOLVED IN THE GROWTH AND PROGRESSION OF CRC. KDR (VEGFR2) IS THE MAIN PRO-ANGIOGENIC RECEPTOR FOR VEGF AND SEEMS TO PLAY AN IMPORTANT CRUCIAL ROLE IN TUMOR ANGIOGENESIS. THE AIMS OF THIS STUDY WERE TO MEASURE RELATIVE EXPRESSION OF KDR GENE IN TUMOR AND MARGINAL TISSUES IN CRC PATIENTS AND TO ASSAY THE CORRELATION OF KDR MRNA EXPRESSION LEVEL WITH CLINICO-PATHOLOGICAL FACTORS...

INTRODUCTION & AIM: COLORECTAL CANCER IS ONE OF THE MAIN CAUSES OF CANCER RELATED DEATH WORLDWIDE. CRC ARISES FROM MUTATIONS IN DIFFERENT GENES. ONE OF THE MOST IMPORTANT MUTATIONS IN THIS TYPE OF CANCER IS IN THE K-RAS (KIRSTEIN RAT SARCOMA) GENE. THE MOST IMPORTANT MUTATIONS IN KRAS GENE OCCUR IN 12TH AND 13TH CODON OF THE SECOND EXON. MUTATIONS THAT OCCUR IN THIS AREA, ARE VERY IMPORTANT FOR PREDICTING THE RESPONSE OF PATIENTS TO ANTI-EGFR THERAPIES LIKE CTUXIMAB AND PANITUMUMAB. IN THIS STUDY WE AIMED TO STUDY THESE MUTATIONS BY TWO DIFFERENT METHODS...

INTRODUCTION & AIM: THE THIRD MOST COMMON CAUSE OF CANCER DEATH IN THE WORLD IS GASTRIC CANCER. THE POTENTIAL TREATMENTS OF DIFFERENT CHEMOTHERAPY AGENTS HAVE BEEN EVALUATED FOR GASTRIC CANCERS. RECENT RESEARCHES HAVE BEEN FOCUSED ON NATURAL AGENTS WHICH LESS TOXIC AND EFFICIENT. PINEAPPLE EXTRACT, A NATURAL COMPOUND, HAVE BEEN INVESTIGATED AS A POTENTIATED ANTICANCER EXTRACT. THE AIM OF THIS STUDY WAS PERFORMED TO EVALUATE THE CYTOTOXIC EFFECTS OF PINEAPPLE EXTRACT ON, HUMAN GASTRIC (AGS) CELLS UNDER IN VITRO CONDITIONS...

INTRODUCTION: COLORECTAL CANCER IS THE THIRD PREVALENT CANCER IN THE WORLD AND THE SECOND CAUSE OF DEATH AMONG THE CANCERS. CONSIDERING THE INCREASING TREND OF THIS CANCER, A STUDY WAS APPLIED WITH THE OBJECTIVE OF DETECTING THE RISK FACTORS OF COLORECTAL CANCER...

LIVER METASTASES ARE A FREQUENT ONCOLOGICAL SITUATION IN COLORECTAL CANCER AND GLOBALLY ONLY 20% OF PATIENTS PRESENTING THEM ARE CANDIDATES FOR SURGICAL RESECTION. WHILE SYSTEMIC CHEMOTHERAPY IS AN OPTION FOR PATIENTS PRESENTING SIGNIFICANT METASTATIC DISEASE BURDEN, RADIOTHERAPY (RT) IS A SAFE, WELL-TOLERATED LOCAL TREATMENT THAT CAN OFFER A LONGER TUMOR CONTROL AND SYMPTOMS CONTROL...

BACKGROUND: STOMACH CANCER (SC) IS THE SECOND LEADING CAUSE OF CANCER DEATH WITH THE RATE OF 10.4% IN THE WORLD. THE CORRELATION BETWEEN THE INCIDENCE AND MORTALITY RATES OF SC AND HUMAN DEVELOPMENT INDEX (HDI) HAS NOT BEEN GLOBALLY DETERMINED. THEREFORE, THIS STUDY AIMED TO DETERMINE THE ASSOCIATION BETWEEN THE INCIDENCE AND MORTALITY RATES OF SC AND HDI IN VARIOUS REGIONS...

INTRODUCTION & AIM: COLORECTAL CANCER IS ONE OF THE MOST COMMON CANCERS IN THE WORLD, WITH OVER 1.2 MILLION NEW CASES DIAGNOSED EACH YEAR. DESPITE IMPROVEMENTS IN SCREENING FOR EARLY DIAGNOSIS, A HISTORY OF BREAST CANCER CONTINUES TO BE REPORTED AS A RISK FACTOR FOR COLORECTAL CANCER...

INTRODUCTION & AIM: GASTRIC CANCER IS NOW THE FIFTH MOST COMMON CANCER IN THE WORLD, AND THE THIRD LEADING CAUSE OF CANCER DEATH. THE CUCURBITACINS ARE A GROUP OF TETRACYCLIC TRITERPENOIDS FOUND PRIMARILY IN THE CUCURBITACEAE FAMILY...

INTRODUCTION: NOW CANCER IS AMONG THE TOP THREE CAUSES OF DEATH IN DEVELOPED COUNTRIES AND ALSO IN IRAN.THE INCIDENCE OF CANCER VARIES IN DIFFERENT SOCIETIES AND ITS EPIDEMIOLOGICAL CHARACTERISTICS, ESPECIALLY GASTROINTESTINAL CANCERS IN RECENT DECADES HAS BEEN A FUNDAMENTAL CHANGE.THE AIM OF THIS STUDY IS TO DETERMINE THE EPIDEMIOLOGY OF GASTROINTESTINAL CANCERS IN IRAN...

INTRODUCTION & AIM: COLORECTAL CANCER IS ONE OF THE MOST PREVALENT CANCERS DIFFERENT COUNTRIES, INCLUDING IRAN. NO COMPREHENSIVE STUDY HAS BEEN DONE IN THE COUNTRY FOR COLORECTAL CANCER, BUT INFORMATION ON THE INCIDENCE AND TRENDS IS ESSENTIAL TO PLANNING. THIS STUDY AIMED TO EVALUATE THE OCCURRENCE AND MORPHOLOGY OF COLORECTAL CANCER AND ITS TREND IN IRAN...

COLORECTAL CANCER (CRC) IS ONE OF THE MOST COMMON CANCERS IN THE WORLD AND CARRIES THE SECOND HIGHEST MORTALITY RATE. CANCER STEM CELLS (CSCS) ARE A SMALL GROUP OF CELLS IN TUMOR TISSUE WITH THE CHARACTER OF STEM CELL, SUCH AS THE POTENTIAL OF SELF-RENEW, MULTILINEAGE DIFFERENTIATION, MULTIDRUG RESISTANCE AND TUMORI-GENESIS. THEY SHOW CHARACTERISTICS OF TUMOR CELL, SUCH AS THE ABNORMAL OF PROTO-ONCOGENE AND TUMOR SUPPRESSOR GENE. THEIR DAUGHTER CELLS ARE INCOMPLETE DIFFERENTIATION AND WITH FUNCTIONAL DEFECTS...

COLORECTAL CANCER (CRC) IS THE FOURTH MOST COMMON CAUSE OF CANCER MORTALITY WORLDWIDE. PATIENTS WITH LYNCH AND FAP, TOGETHER WITH POSITIVE FAMILY HISTORY CONSTITUTING UP TO 30% OF CRC. MICROSATELLITE INSTABILITY (MSI) ABOUT 15% OF SPORADIC CRC. MUTATIONS IN THE MISMATCH REPAIR (MMR) GENES SUCH AS HMLH1 OR HMSH2 GENES AND CPG ISLAND METHYLATOR PHENOTYPE (CIMP) HIGH ESPECIALLY IN MLH1 AND MSH2 ARE THE MOST COMMON DEFECTS THAT HAVE BEEN SEEN IN THESE PATIENTS...

INTRODUCTION & AIM: THE BRCA1 AND BRCA2 GENES CONFER INCREASED SUSCEPTIBILITY TO BREAST AND OVARIAN CANCER AND TO A SPECTRUM OF OTHER CANCERS. THERE IS CONTROVERSY REGARDING THE RISK OF COLORECTAL CANCER CONFERRED BY GERM LINE MUTATIONS IN THESE TWO GENES...

INTRODUCTION & AIM: THIS STUDY EXAMINED THE INCIDENCE OF GASTROINTESTINAL CANCERS IN THE POPULATION COVERED BY THE CITY OF ALBORZ DUE TO CHANGES IN THE INCIDENCE OF DISEASES AND IMPRESSIVE INCREASING OF NON-COMMUNICABLE DISEASES (CANCERS, CARDIOVASCULAR DISEASE AND DIABETES) IN THE COUNTRY AND DRAMATIC EFFECTS OF THESE DISEASES ON HEALTH, AND ALSO REGARDING THAT THE MOST COMMON CANCERS IN IRAN ARE DIGESTIVE TRACT CANCERS...

INTRODUCTION & AIM: COLORECTAL CANCER IS THE THIRD MOST COMMON CANCER IN THE WORLD AND GENETIC AND EPIGENETIC ALTERATIONS PLAY AN IMPORTANT ROLE IN ITS DEVELOPMENT. TUMOR SUPPRESSOR OGDHL GENE IS ONE OF THE SUBUNIT OF OXOGLUTARATE DEHYDROGENASE COMPLEX WHICH IS INVOLVED IN THE TCA CYCLE AND IS INDIRECTLY RESPONSIBLE FOR THE INDUCTION OF APOPTOSIS. METHYLATION OF ITS PROMOTER CAN REDUCE ITS EXPRESSION WHICH IN ITS TURN MAY AFFECT THE PROCESS OF APOPTOSIS. THIS STUDY WAS AIMED TO COMPARE THE METHYLATION STATUS OF THE PROMOTER REGIONS OF OGDH LGENE IN TUMORAL AND NONTUMORAL SAMPLES OF PATIENTS WITH COLORECTAL CANCER...

INTRODUCTION: STOMACH CANCER CAUSED BY EXCESSIVE GROWTH OF MALIGNANT CELLS IN THE STOMACH AND ITS EARLY SYMPTOMS ARE VAGUE. SYMPTOMS OF STOMACH CANCER LATE WILL BE DETERMINED AND WILL ADVANCE RAPIDLY TO OTHER ORGANS. CONSIDERING THAT CERTAIN MEASURES HAVE NOT BEEN IDENTIFIED FOR SCREENING, CHANGES IN LIFESTYLE AND DIETARY HABITS ARE EFFECTIVE IN DISEASE PATTERN. THIS STUDY WAS CONDUCTED TO INVESTIGATE DIETARY HABITS IN PEOPLE...

INTRODUCTION & AIM: COLORECTAL CANCER IS CANCER THAT OCCURS IN THE COLON OR RECTUM.IS THE SECOND LEADING CANCER KILLER IN THE UNITED STATES, BUT IT DOESN’T HAVE TO BE. A NUMBER OF FACTORS AFFECT THE DISEASE RISK THAT THEY CAN IDENTIFY LIFESTYLE CHANGES THAT LEAD TO WAYS...

INTRODUCTION & AIM: CANCER IS ONE OF THE MAJOR CAUSES OF DEATH (13%) IN THE WORLD AND THE THIRD LEADING CAUSE OF DEATH IN IRAN. THE EXACT CAUSE OF THE DISEASE IN MODERN MEDICINE, IS UNCLEAR. IT IS ESTIMATED THAT MORE THAN A THIRD OF CASES IF DETECTED EARLY, ARE CURABLE. IN THE VIEWPOINTS OF TRADITIONAL PERSIAN MEDICINE (TPM), CANCER IS A TYPE OF SWELLING AND THE AIM OF THIS STUDY IS TO DERIVE THE PRODUCT BASED ON TRADITIONAL PERSIAN MEDICINE TO HELP CANCER TREATMENT...

INTRODUCTION: THE INCIDENCE OF PRIMARY COLORECTAL LYMPHOMAS IS RARE, COMPRISING 10-20% OF GASTROINTESTINAL LYMPHOMAS AND ONLY 0.2-0.6% OF LARGE BOWEL MALIGNANCIES. THE AIM OF THIS STUDY IS REPORT A RARE CASE WITH RECTAL ADENOCARCINOMA IN PATIENT WITH DIFFUSE LARGE B-CELL LYMPHOMA OF THE ILEOCECAL...

1. OPTIMAL SURGERY (TME AND APE) REDUCE LOCAL RECURRENCE AND IMPROVE SURVIVAL.2. GOOD MRI MAY GUIDE SURGERY AND SELECTIVE PREOPERATIVE RADIOTHERAPY. 3. RADIOTHERAPY AND SURGERY OVERTREATMENT MAY LEAD TO POORER QUALITY OF LIFE...

INTRODUCTION: COLORECTAL CANCER IS ONE OF THE THREE CANCERS WITH HIGHEST INCIDENCE RATES IN THE WORLD. DUE TO THE GROWING PREVALENCE OF THIS DEADLY CANCER, SCREENING AND EARLY DETECTION METHODS ARE NEEDED. DNA METHYLATION IS LINKED TO COLORECTAL CANCER AND CAN BE IDENTIFIED BY CHECKING THE APPROPRIATE METHYLATION BIOMARKERS IN PERIPHERAL BLOOD AS AN EARLY NON-INVASIVE DIAGNOSIS...

INTRODUCTION & AIM: THE APOPTOTIC FACTORS SUCH AS BID, BIM AND APAF1 HAVE A MAIN ROLE IN INDUCING APOPTOTIC PATHWAYS. FURTHERMORE, SOME COMPOUNDS SUCH AS CARVACROL CAN ACTIVE THESE APOPTOTIC FACTORS TO CAUSE APOPTOSIS. IN THIS STUDY, THE COMET ASSAY TECHNIQUE AND MOLECULAR DYNAMICS SIMULATIONS WERE APPLIED TO INVESTIGATE THE EFFECTS OF CARVACROL ON INDUCTION OF APOPTOTIC PATHWAY...

WNT SIGNAL TRANSDUCTION PATHWAYS ARE FUNDAMENTAL MECHANISMS THAT DIRECT CELL PROLIFERATION, CELL POLARITY AND CELL FATE DETERMINATION DURING EMBRYONIC DEVELOPMENT AND CELLULAR HOMEOSTASIS. THE CANONICAL WNT SIGNALING PATHWAY FUNCTIONS BY REGULATING THE PROTEIN STABILIZATION OF B-CATENIN, A TRANSCRIPTIONAL CO ACTIVATOR THAT CONTROLS THE EXPRESSION OF SOME IMPORTANT CELLULAR GENES. UPREGULATION OF B-CATENIN TRANSCRIPTIONAL ACTIVITY CAN LEAD TO NUMEROUS FORMS OF HUMAN CANCER, MOST NOTABLY HEREDITARY AND SPORADIC FORMS OF COLON CANCER...

INTRODUCTION: ACCORDING TO A CHANGE IN THE TREND OF INCREASING INCIDENCE OF DISEASES AND NON-COMMUNICABLE DISEASES IN THE COUNTRY AND THE BROAD IMPACT OF THESE DISEASES ON PREMATURE DEATH, THE IMPORTANCE OF CANCER IS OBVIOUS TO EVERYBODY IN SOCIETY, REGARDING TO THE FACT THAT GASTROINTESTINAL CANCER IS THE MOST COMMON CANCERS, THIS STUDY EXAMINES THE EPIDEMIOLOGY OF DEATH DUE TO GASTROINTESTINAL TRACT IN THE CITY OF ALBORZ IN 1393.

INTRODUCTION & AIM: HEPATITIS B VIRUS (HBV) IS THE LEADING CAUSE OF CIRRHOSIS AND HEPATOCELLULAR CARCINOMA (HCC) IN THE WORLD. THE MAIN GOAL OF THERAPY IN CHRONIC HEPATITIS B (CHB) PATIENTS INCLUDES THE DRIVING VIRAL REPLICATION TO THE LOWEST POSSIBLE LEVEL IN ORDER TO HALT THE PROGRESSION OF CHRONIC HEPATITIS TO PREVENT THE DEVELOPMENT OF LIVER FAILURE, DUE TO SUBSEQUENT LIVER CIRRHOSIS, AND THE EMERGENCE OF HCC. THE AIM OF THIS STUDY WAS THE DETECTION OF RTA181T/SW172* MUTANT FREQUENCY AMONG CHRONIC HBV PATIENTS WHO SHOW INCOMPLETE RESPONSE TO ANTIVIRAL THERAPY...

INTRODUCTION & AIM: CANCER IS ONE OF THE CHRONIC DISEASES THAT REDUCE THE SPIRITUAL WELL-BEING AND LIFE SATISFACTION. THEREFORE, THIS RESEARCH AIMED TO DETERMINE THE EFFECT OF EDUCATIONAL INTERVENTION ON SPIRITUAL WELL-BEING AND LIFE SATISFACTION OF PATIENTS WITH GASTROINTESTINAL CANCER IN CITY OF ILAM...

INTRODUCTION & AIM: RESVERATROL IS AN ACTIVE COMPONENT OF GRAPE, WHICH HAS BEEN SHOWN TO INHIBIT PROLIFERATION OF A WIDE VARIETY OF TUMOR CELLS. THE ABILITY OF RESVERATROL TO ENHANCE ANTI-PROLIFERATIVE EFFECTS OF ETOPOSIDE IN WILD TYPE P53 LIVER CARCINOMA (HEPG2) AND COLON CANCER (HCT-116) CELLS WAS INVESTIGATED WITH FOCUSING ON P53 ACTIVATION...

GASTRIC CANCER IS ONE OF THE MOST COMMON CANCERS AND IT IS THE THIRD CAUSE DEATHS FROM CANCER IN THE WORLD. D133P53 ISOFORM HAS ANTI-APOPTOTIC ROLE AND IT IS EXPRESSED FROM AN INTERNAL PROMOTER THAT LOCATED IN INTRON 4 OF P53 GENE. MUTATIONS IN SEQUENCES OF INTRON 4 BY CHANGING THE TRANSCRIPTION FACTORS BINDING SITES CAN CHANGE INTERNAL PROMOTER ACTIVITY AND EXPRESSION OF D133P53 ISOFORM. THE AIM OF THIS STUDY IS THE IDENTIFICATION OF MUTATIONS OF INTRON 4 OF P53 GENE IN PATIENTS WITH GASTRIC CANCER...

WITH OPTIMAL MRI STAGING, NEOADJUVANT (CHEMO) RADIATION (CHRT) IN HIGH RISK PATIENTS, AND GOOD SURGERY (TOTAL MESORECTAL EXCISION), LOCAL RECURRENCE RATES ARE DOWN TO 5%. THIS IMPROVED ONCOLOGICAL OUTCOME COMES AT A COST. ESPECIALLY FOR THE ELDERLY AND IN PATIENTS WITH COMORBIDITY, RECTAL RESECTIONS ARE FORMIDABLE PROCEDURES WITH SUBSTANTIAL PERI-OPERATIVE MORBIDITY AND MORTALITY...

INTRODUCTION & AIM: GASTRIC CANCER IS CONSIDERED AS A MAJOR CAUSE OF DEATH FROM CANCER WORLDWIDE, ALTHOUGH ITS INCIDENCE HAS DECREASED DURING THE LAST DECADE. GASTRIC CANCER IS THE LEADING CAUSE OF CANCER DEATH IN IRAN AND KURDISTAN PROVINCE IS AMONG THE PROVINCES WITH THE HIGHEST INCIDENCE RATE...

INTRODUCTION: COLORECTAL CANCER IS THE FOURTH MOST COMMON CANCER IN MEN AND THE THIRD MOST COMMON IN WOMEN. BRUCELLA INFECTIONS IN IMMUNE COMPROMISED HOSTS (LIKE CLL) ARE RELATIVELY RARE. HEREIN, WE REPORTED FIRST CASE REPORT, A PATIENT HAVE BEEN DIAGNOSED AS SIMULTANEOUS CLL AND BRUCELLOSIS DURING HIS FOLLOW UP THAT SHE INDICATED A SUBSEQUENT NEOPLASM AFTER CLL ACCORDING TO OUR KNOWLEDGE...

A GREAT DEAL OF RESEARCH HAS DEMONSTRATED THE EXISTENCE OF CANCER STEM CELLS (CSCS) IN SEVERAL HUMAN CANCERS IN RECENT YEARS. CSCS ARE MINOR POPULATION OF TUMORIGENIC CELLS THAT ARE CAPABLE OF CONTINUOUS SELF-RENEWAL AND DIFFERENTIATION WHICH MAY BE REGULATED BY SOME SIGNALING PATHWAYS INCLUDING WNT/B-CATENIN, HEDGEHOG, AND NOTCH. IN ADDITION, RECENT STUDIES INDICATE THAT CSCS MAY BE RESPONSIBLE FOR TUMOR RELAPSE AND RESISTANCE TO THERAPY...

INTRODUCTION & AIM: THE PROGNOSIS OF COLORECTAL CANCER IS RELATIVELY GOOD IN TERMS OF SURVIVAL. IN MANY PROGNOSTIC STUDIES, PATIENTS MAY BE EXPOSED TO SEVERAL TYPES OF COMPETING EVENTS. THESE DIFFERENT CAUSES OF DEATH ARE CALLED COMPETING RISKS. TO INVESTIGATE THE PROGNOSIS FACTORS OF SURVIVAL OF PATIENTS WITH COLORECTAL CANCER IN PRESENCE OF COMPETING RISKS, USING. FOUR-PARAMETER LOG-LOGISTIC DISTRIBUTION...

INTRODUCTION AND AIM: DOLICHOCOLON IS ONE OF THE REASONS THAT LEADS TO CONSTIPATION. THIS ABNORMALITY INCREASES THE LENGTH OF THE LARGE INTESTINE AND SOMETIMES IT CAUSES VOLVULUS. THE MAIN GOAL OF THIS RESEARCH IS THE EPIDEMIOLOGICAL SURVEY OF DOLICHOCOLON ABNORMALITY AND SOME PARAMETERS INCREASING ITS INCIDENCE SUCH AS DEMOGRAPHIC ONES LIKE SEX, HERITAGE, INTESTINAL DISORDERS, BMI AND ETC...

INTRODUCTION & AIM: TO EVALUATE THE MOST APPROPRIATELY EXTEND OF GASTRIC RESECTION FOR PEDIATRIC GIST ACCORDING TO CLINICAL AND PATHOLOGICAL EVALUATION OF RESECTED TUMOR.METHODS: HERE WE REVIEW THE PATHOLOGICAL AND SURGICAL FINDING OF 25 CASES WITH GASTRO INTESTINAL STROMAL TUMOR (GIST) BY INVOLVEMENT OF STOMACH AND EVALUATE CORRELATION OF PATHOLOGICAL AND SURGICAL FINDING AS WELL AS MANAGEMENT STRATEGIES DURING THE EIGHT-YEAR PERIOD FROM MARCH 2007 TO MAY 2015 FOR RESPONSE TO CHEMOTHERAPY ACCORDING TO PATHOLOGIC RESULTS SHOWING MARGINAL INVOLVEMENT OR NOT...

INTRODUCTION & AIM: GASTRIC CANCER (GC) IS THE FOURTH HUMAN MALIGNANT DISEASE AND THE SECOND LEADING CAUSE OF CANCER DEATH IN THE WORLD. THIS CANCER IS AN ASYMPTOMATIC DISEASE AT EARLY STAGES AND SO IS OFTEN DETECTED AT ADVANCED STAGE. CIRCULATING MICRORNAS PLAY AN IMPORTANT ROLE IN DIAGNOSIS AND ASSESSMENT OF PATIENTS WITH CANCER AND THEREFORE DISCOVERY OF THESE MOLECULES IS PROMISING TO USE OF THEM AS NONINVASIVE BIOMARKERS IN THE SCREENING OF CANCER PATIENTS. IN THE PRESENT STUDY, WE ANALYZED THE EXPRESSION OF MIR-103 IN PLASMA OF VOLUNTEERS WITH GC AND HEALTHY INDIVIDUALS TO INVESTIGATE FUNCTION OF THIS MOLECULE AS A NON-INVASIVE DIAGNOSTIC BIOMARKER...

INTRODUCTION: RECORDS FROM THE CANCER REGISTRY SYSTEM OF IRAN INDICATE THAT CRC IS THE THIRD AND FOURTH MOST COMMON CANCER IN IRANIAN MEN AND WOMEN RESPECTIVELY. IT IS ESTABLISHED THAT CRC IS A COMPLEX DISEASE, AND ITS INCIDENCE IS RELATED TO BOTH GENETIC AND ENVIRONMENTAL FACTORS. IN THIS STUDY WE INVESTIGATED THE ENVIRONMENTAL FACTORS ASSOCIATED WITH COLORECTAL CANCER IN ISFAHAN, IRAN...

INTRODUCTION & AIM: COLORECTAL CANCER IS THE SECOND COMMON GASTROINTESTINAL CANCERS AND THE THIRD COMMON CANCER IN IRAN. THE AIM OF THIS STUDY IS TO DETECT GEOGRAPHICAL DISTRIBUTION AND IDENTIFY HIGH RISK OR LOW RISK CLUSTERS OF COLORECTAL CANCER IN IRAN...

BACKGROUND AND AIM: ACCORDING TO WORLD HEALTH ORGANIZATION (WHO) MOST OF CHRONIC DISEASES SUCH CANCER, CAN BE PREVENTIVE BY IDENTIFYING RISK FACTORS LIKE UNHEALTHY DIET, SMOKING AND LACK OF PHYSICAL ACTIVITY. THESE FACTORS ARE DUE TO UNHEALTHY LIFE STYLE, AND IT IS NECESSARY TO DECREASE THEM BY EDUCATIONAL INTERVENTIONS. THE AIM OF CURRENT STUDY WAS DETERMINING THE EFFECTIVENESS OF EDUCATIONAL INTERVENTION BASED ON HEALTH BELIEF MODEL (HBM) ON NUTRITIONAL PREVENTIVE BEHAVIORS FROM COLORECTAL CANCER AMONG STAFF OF SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES' FACULTIES...

INTRODUCTION: STUDIES HAVE SHOWN THAT CANCER IS AMULTI FACTORIAL DISEASE THAT IN ITS PATHOGENESIS, IN ADDITION TO GENETIC DISORDERS, THE EFFECT OF ENVIRONMENTAL FACTORS CAN ALSO BE POINTED. AMONG ALL ENVIRONMENTAL FACTORS, TOBACCO THAT CONSIDERED AS THE LEADING CAUSE OF RESPIRATORY AND CARDIOVASCULAR DISEASE PLAYS A KEY ROLE IN CANCER PATHOGENESIS AND PROGRESSION. MORE THAN 5, 000 CHEMICALS AND 62 CARCINOGENES HAVE BEEN DETECTED IN TOBACCO, WHICH COULD CONTRIBUTE TO TUMORGENESIS THROUGH ACTIVATING ONCOGENES, INHIBITION OF TUMOR SUPPRESSOR GENES, GENETIC AND EPIGENETIC CHANGES, ALTERATION OF GROWTH PATHWAYS, ANGIOGENESIS AND METASTASIS...

INTRODUCTION AND AIM: PH GRADIENT IN CANCER CELLS IS DIFFERING FROM NORMAL CELLS. IT IS BECAUSE OF PRODUCTION OF LACTIC ACID AND HYDROLYSIS OF ATP IN TUMOR HYPOXIC ENVIRONMENT. ACCOMMODATION WITH THIS MORE ACIDIC SITUATION IS CRUCIAL FOR CANCER CELLS VIABILITY ALSO METASTATIC POTENTIAL. FOR THIS REASON PH-REGULATING FACTORS IMPORTANCE IS OBVIOUS. OUR STUDY INDICATES A NEW CHLORIDE CHANNEL IN HEPATOCYTE ROUGH ENDOPLASMIC RETICULUM (RER) THAT WAS PH-SENSITIVE...

NEUROENDOCRINE TUMORS (NETS) ARE A GENETICALLY DIVERSE GROUP OF MALIGNANCIES THAT SOMETIMES PRODUCE PEPTIDES THAT CAUSE CHARACTERISTIC HORMONAL SYNDROMES. NETS CAN BE CLINICALLY SYMPTOMATIC (FUNCTIONING) OR SILENT (NONFUNCTIONING); BOTH TYPES FREQUENTLY SYNTHESIZE MORE THAN ONE PEPTIDE, ALTHOUGH OFTEN THESE ARE NOT ASSOCIATED WITH SPECIFIC SYNDROMES...

INTRODUCTION & AIM: IT IS ESTIMATED THAT THE INCIDENCE OF CANCER BY 2025, DEVELOPED COUNTRIES WILL INCREASE BY ABOUT 45%. THE NATURE OF CANCER AND ITS TREATMENTS SUCH AS CHEMOTHERAPY, SURGERY AND RADIATION THERAPY, CHANGES THE COURSE OF LIFE AND CAUSING A LOT OF PROBLEMS THAT ALL THESE PROBLEMS CAN BE ALL PHYSICAL, PSYCHOLOGICAL, SOCIAL, ECONOMIC AND THE PATIENT'S FAMILY. THIS EXPERIENCE PSYCHOLOGICAL AND PHYSICAL SYMPTOMS SUCH AS CONSTIPATION AND DIARRHEA SYMPTOM INDICES CANCER PATIENTS CAN HAVE A MAJOR IMPACT ON QUALITY OF LIFE. THIS ARTICLE IS PART OF A RESEARCH WITH IRCT2015012720834N1 COD WHERE WE DECIDED TO THE IMPACT OF BLEND EDUCATIONAL PROGRAM FOR BOWEL ISSUES THAT AFFECT THE QUALITY OF LIFE FOR CANCER PATIENTS SHAFA 2014 MEASURE...

INTRODUCTION & AIM: GASTRIC CANCER IS THE FOURTH MOST COMMON CANCER IN THE WORLD, BUT THE SECOND LEADING CAUSE OF CANCER DEATH, AFTER LUNG CANCER. H.PYLORI IS THE STRONGEST KNOWN RISK FACTOR FOR DEVELOPMENT OF GASTRIC CANCER. AMONG THE MEDIATORS INDUCED IN RESPONSE TO INFECTION, MICRORNAS HAVE THE PROBABLE ROLE TO PLAY A MAJOR INFLUENCE ON THE EFFECT OF BACTERIA-HOST INTERACTION. MICRORNAS ARE 20–25 NUCLEOTIDES IN LENGTH AND NON-CODING RNAS THAT THEY CAN REGULATE GENE EXPRESSION BY POSTTRANSCRIPTIONAL CONTROL OR BINDING TO THE 3' UNTRANSLATED REGION (UTR) OF MRNAS. IN THIS STUDY FOCUSSES ON THE ASSOCIATION BETWEEN MIR-21 UP REGULATION IN GASTRIC CANCER EPITHELIUM OF H.PYLORI INFECTED GASTRIC CANCER WITH TUMOR SIZE...

INTRODUCTION AND AIM: COLORECTAL CANCER IS THE MOST COMMON GASTROINTESTINAL CANCER. MORE THAN ONE MILLION NEW CANCER CASES ARE REGISTERED YEARLY. THE PREVALENCE OF COLORECTAL CANCER IN IRAN IS INCREASING. IDENTIFYING GENES AND PATHWAYS WITCH ARE INVOLVED IN CANCER AND GENE EXPRESSION CHANGES CAN HELP EARLY DIAGNOSIS AND TREATMENT. WE EVALUATED THE EXPRESSION OF NUDCD1, A TUMOR ANTIGEN, TO REACH A NEW MOLECULAR INSIGHT OF COLORECTAL CANCER...

INTRODUCTION: DESPITE REMARKABLE ADVANCES IN MEDICAL SCIENCE, CANCER CONTINUES TO BE ONE OF THE MOST IMPORTANT DISEASE OF THIS CENTURY AND THE SECOND LEADING CAUSE OF DEATH AFTER CARDIOVASCULAR DISEASES. DIAGNOSIS OF CANCER, PARTICULARLY CANCERS OF THE DIGESTIVE TRACT CAN MAKE SPIRITUAL DISTRESS IN PERSON. THIS STUDY AIMED TO INVESTIGATE THE ROLE OF SPIRITUALITY AND SPIRITUAL HEALTH IN PATIENTS WITH GASTROINTESTINAL CANCER...

INTRODUCTION AND AIMS: COLORECTAL CANCER (CRC), ONE OF THE MOST COMMON MALIGNANT DISORDERS, IS A MAJOR CAUSE OF DEATH WORLDWIDE. ALTHOUGH THE RATE OF INCIDENCE OF CRC INCREASES WITH AGE, BEGINNING AGE OF ITS INCIDENCE HAS OVERWHELMINGLY DECREASED LATELY. CRC SURVIVAL IS DEPENDENT UPON THE STATE OF DISEASE AT DIAGNOSIS, THEREFORE FINDING EARLY STAGE MOLECULAR INDICATORS RESULTS IN THE HIGHER CHANCE OF SURVIVAL. WE AIMED TO DETERMINE THE LEVEL OF PLXNA1 EXPRESSION IN CANCEROUS AND NONCANCEROUS TISSUES OF PATIENTS AT DIFFERENT STAGES OF CANCER TO DEVELOP OUR MOLECULAR INSIGHT OF CRC...

BACKGROUND: GASTRIC CANCER IS THE FOURTH MAJOR MALIGNANCY AND THE SECOND LEADING CAUSE OF CANCER-RELATED DEATHS WORLDWIDE. STUDIES HAVE SHOWN THAT DIETARY COMPONENTS ARE IMPLICATED IN THE ETIOLOGY OF GASTRIC CANCER. THE RELATIONSHIP BETWEEN DIET-RELATED INFLAMMATION AND THE RISK OF GASTRIC CANCER HAS NOT BEEN INVESTIGATED...

INTRODUCTION: GASTRIC CANCER IS THE SECOND REASON OF CANCER-RELATED DEATH IN THE WORLD WITH PARTICULARLY HIGH PREVALENCE IN EAST ASIA. RECENTLY, THE FUNCTION OF LONG NON-CODING RNAS (LNCRNAS) AS TUMOR SUPPRESSORS OR ONCOGENE HAS APPEARED IN PREVALENT CANCER TYPES, SUCH AS GASTRIC CANCER. LINCRNA-P21 IS LOCATED UPSTREAM OF P21 GENE AND ACTIVATES ITS EXPRESSION UNDER THE CONTROL OF P53 TRANSCRIPTION FACTOR...

INTRODUCTION & AIM: MICRORNAS IN COLORECTAL CANCER (CRC) HAVE BEEN PROVIDED A NEW INSIGHT INTO THE CANCER DIAGNOSIS. THESE RNAS HAVE BEEN SUGGESTED AS RELIABLE AND STABLE BIOMARKERS FOR VARIOUS CANCERS. OUR STUDY AIMED TO ANALYZE THE MICRORNA EXPRESSION IN SERUM AND TISSUE SAMPLES IN CRC TO EXAMINE THE POTENTIAL VALUE OF THESE MOLECULES AS DIAGNOSTIC BIOMARKERS...

COLORECTAL CANCER (CRC) IS THE THIRD MOST COMMON CANCER AND THE FOURTH MOST COMMON CAUSE OF CANCER DEATH WORLDWIDE. IMMUNOTHERAPY MODALITIES INCLUDING IMMUNE CHECKPOINT INHIBITORS SUCH AS ANTI-PROGRAMMED DEATH 1 (PD-1) ANTIBODY AND ANTI-PROGRAMMED DEATH LIGAND 1 (PD-L1) ANTIBODY HAVE DEMONSTRATED EFFICACY IN A MULTITUDE OF HUMAN TUMOR TYPES. RECENT EVIDENCE SUPPORTS USE OF THESE ANTIBODIES IN TUMORS WITH MICROSATELLITE INSTABILITY (MSI-H)...

CURRENTLY, WITH GOOD PRE-OPERATIVE STAGING (MRI), NEOADJUVANT (CHEMO) RADIATION (CHRT), AND GOOD QUALITY SURGERY (TOTAL MESORECTAL EXCISION), LOCAL RECURRENCE RATES IN RECTAL CANCER ARE AS LOW AS 5%. HOWEVER, THIS EXCELLENT ONCOLOGICAL OUTCOME COMES WITH THE COST OF SUBSTANTIAL PERI-OPERATIVE MORBIDITY AND MORTALITY, AS WELL AS CONSIDERABLE LONG-TERM ANORECTAL AND UROGENITAL DYSFUNCTION. ULTRA-LOW ANASTOMOSES AND INTERSPHINCTERIC RESECTIONS, ESPECIALLY AFTER NEOADJUVANT RT OFTEN LEAVE THE PATIENT WITH A DUBIOUS DEGREE OF CONTINENCE.

COLORECTAL CANCER IS THE THIRD MOST COMMON CANCER IN THE WORLD AND IS THE FOURTH CAUSE OF DEATH DUE TO CANCER. EPIGENETIC MODIFICATIONS THAT INCLUDE POST-TRANSLATIONAL PROCESSES ON HISTONE SUCH AS ACETYLATION, METHYLATION OR PHOSPHORYLATION, IT MAY BE EFFECTIVE IN CANCER PROGRESSION. SINCE THE CONTROL COLORECTAL CANCER PREVALENCE IN THE COUNTRY WAS REQUIRED, IT INVESTIGATED THE RELATIONSHIP BETWEEN HISTONE DEACETYLASE ENZYMES WITH COLORECTAL CANCER IN THIS REVIEW...

INTRODUCTION & AIM: GLOBALLY, GASTROINTESTINAL CANCERS ARE THE MOST COMMON CANCERS IN THE OLDER POPULATION AGED 65 AND OLDER. DUE TO SUCH HIGH PREVALENCE, THIS STUDY AIMED TO PROVIDE THE INCIDENCE RATE OF THESE CANCERS IN SUCH POPULATION AND OBSERVE THE CHANGING IMPACT OF THESE CANCERS WITH INCREASING AGE VERSUS YOUNG ADULT (15 TO 44) AND MIDDLE AGE (45 TO 64) GROUPS...

INTRODUCTION: CRC RESULTS FROM A PROGRESSIVE ACCUMULATION OF GENETIC AND EPIGENETIC ALTERATIONS THAT LEAD TO UNCONTROLLED GROWTH OF CELLS IN THE COLON AND RECTUM. CELL SURFACE GROWTH FACTOR RECEPTORS PLAY A VITAL ROLE. RON RECEPTOR TYROSINE KINASE, ONE OF THESE RECEPTOR, IS ACTIVATED BY BINDING OF ITS LIGAND, HGFL. THE OVEREXPRESSION OF RON HAVE DOCUMENTED IN A VARIETY OF HUMAN CANCERS INCLUDING BREAST, COLON, LIVER, PANCREAS, AND BLADDER. THE AIM OF THIS STUDY WAS TO REVEAL MISREGULATION OF RON IN CRC TISSUES COMPARE TO NORMAL ADJACENT TISSUE...

INTRODUCTION & AIM: POLYMERS ARE WIDELY USED AS BIOMATERIALS DUE TO THEIR FAVORABLE PROPERTIES. ESPECIALLY IN THE FIELD OF TARGETED DRUG DELIVERY, POLYMER PLAYED A SIGNIFICANT ROLE BECAUSE IT CAN DELIVER THERAPEUTIC AGENTS DIRECTLY INTO THE INTENDED SITE OF ACTION, WITH SUPERIOR EFFICACY...

INTRODUCTION AND AIM: COMPARED TO OTHER CANCERS, THE GASTROINTESTINAL ONES ARE WORSE IN PROGNOSIS AND 5-YEAR SURVIVAL RATE. THESE CANCERS HAVE NOT A SPECIFIC TREATMENT AND ARE NOT PREDETERMINED, BUT SEEM TO BE MANAGEABLE BY AWARENESS OF PREVENTIVE MEASURES. THE NUTRITION IS CONSIDERED AS THE MAIN ENVIRONMENTAL FACTOR IN PATHOGENESIS OF 35% OF CANCERS. THE PURPOSE OF THIS STUDY WAS TO COMPARE THE EATING HABITS BETWEEN HEALTHY PEOPLE AND PATIENTS WITH GASTROINTESTINAL CANCERS...

INTRODUCTION AND AIM: GASTROINTESTINAL MALIGNANCIES ARE OF THE MOST COMMON CANCERS AND ACCOUNT FOR HALF OF ALL CANCER RELATED MORTALITIES IN IRANIAN POPULATION. THERE WAS STRONGEST ASSOCIATION BETWEEN HUMAN PAPILLOMAVIRUS (HPV) INFECTION AND UROGENITAL CANCERS IN PARTICULAR CERVIX. HOWEVER THERE IS NO CLEAR CAUSAL RELATIONSHIP IN ALL TYPES OF CANCERS, INCLUDING GASTROINTESTINAL CANCERS. THEREFORE PRESENT STUDY AS A SYSTEMATIC REVIEW AND META-ANALYSIS WAS DESIGNED TO EVALUATE THE PREVALENCE OF HPV IN GASTROINTESTINAL CANCERS AND ITS RELATION WITH THESE CANCERS...

INTRODUCTION & AIM: SUCCESSFUL GENE THERAPY AND DNA VACCINE SYSTEMS ARE MOSTLY DEPENDENT ON A SAFE AND EFFICIENT DELIVERY VECTOR, TO TRANSFER GENETIC MATERIAL FROM CELL MEMBRANE AND FURTHER TRANSCRIPTION AND TRANSLATION PROCESSES. SOME INVESTIGATION HAVE BEEN DISCUSSED THE POTENCY OF CHITOSAN NANO-VECTOR AS A BIODEGRADABLE AND SAFE DELIVERY SYSTEM FOR DRUGS AND NUCLEIC ACID TRANSPORT IN VITRO AND IN VIVO. ACCORDING TO THE IMPORTANCE OF HELICOBACTER PYLORI IN GASTROINTESTINAL CARCINOMA, IT SEEMS NECESSARY TO DEVELOP EFFICIENT THE PROPHYLACTIC OR THERAPEUTIC VACCINE AGAINST IT TO ERADICATE THE INFECTION. IN PRESENT STUDY, WE FOCUSED TO LOAD AN H. PYLORI DNA VACCINE ON THE POSITIVELY CHARGED CHITOSAN NANO-POLYMER...

INTRODUCTION & AIM: ACCORDING TO THE LAST REPORT OF IRAN CANCER REGISTRY, STOMACH, COLORECTAL AND BLADDER CANCERS ARE THE MOST PREVALENT CANCERS. THE PRESENT STUDY FOCUSED ON MODELING THE GEOGRAPHICAL VARIATION OF INCIDENCE AND RISK FACTORS OF MENTIONED CANCERS IN IRAN...

INTRODUCTION & AIM: THE RHOB GENE IS ONE OF THE GENES THAT ARE INVOLVED IN WITH CANCERS SUCH AS GASTRIC CANCER. THIS GENE IS CONTRIBUTED IN CYTOSKELETAL ORGANIZATION AND CELL TRAFFICKING AND ITS EXPRESSION IS DECREASED IN GASTRIC CANCER. THERE ARE A VNTR POLYMORPHISM IN THE PROMOTER OF THE RHOB GENE AND IN THIS STUDY DIFFERENT GENOTYPES OF THIS VNTR IS ASSESSED WITH RISK OF GASTRIC CANCER, FOR THE FIRST TIME...

LEIOMYOSARCOMA IS A MALIGNANT TUMOR OF MESENCHYMAL CELLS AND IS THE MOST COMMON SOFT TISSUE SARCOMA. LEIOMYOSARCOMA IS AN EXTREMELY RARE TUMOR IN OCULAR AND PERIOCULAR REGION AND CAN BE PRIMARY, SECONDARY OR METASTATIC. PRIOR TO THE ADVENT OF C-KIT IMMUNOREACTIVITY, THE MAJORITY OF GASTROINTESTINAL STROMAL TUMORS WERE CLASSIFIED AS LEIOMYOSARCOMA...

INTRODUCTION: MOST STOMACH CANCERS ARE ADENOCARCINOMAS TYPE. USUALLY AFFECTS THE LOWER AND MIDDLE STOMACH. REMOVAL OF GASTRIC CARCINOMA IS ONLY POSSIBLE IF THE CANCER HAS NOT SPREAD TO THE STOMACH AND IS LIMITED. THE AIM OF THIS STUDY IS NURSING CARE AFTER SURGERY FOR GASTRIC CANCER...

INTRODUCTION & AIM: HELICOBACTER PYLORI INFECTION IS ONE OF THE MAIN RISK DETERMINANTS OF GASTRIC NON-CARDIA CANCER (GNCC), WHILE GASTRIC CARDIA CANCER (GCC) HAS NEGATIVE, POSITIVE OR NO ASSOCIATION WITH H. PYLORI INFECTION. ARDABIL HAS THE HIGHEST RATES OF H. PYLORI INFECTION (89%) IN IRAN AND ONE OF THE HIGHEST GCC RATES IN THE WORLD. THE AIM OF PRESENT STUDY WAS TO ANALYZE THE ASSOCIATIONS OF H. PYLORI INFECTION, AGE AND GENDER AND AREA OF RESIDENCE WITH THE RISK OF BOTH THE TYPE OF GC IN THE ARDABIL...

INTRODUCTION: SINCE CANCER IS THE MOST COMMON CAUSE OF DEATH IN THE WORLD POPULATION, THE POSSIBILITY THAT READILY AVAILABLE NATURAL SUBSTANCES FROM PLANTS, VEGETABLES, HERBS, AND SPICES MAY BE BENEFICIAL IN THE PREVENTION OF CANCER WARRANTS CLOSER EXAMINATION.SAFFRON IS A SPICE DERIVED FROM THE FLOWER OF THE SAFFRON CROCUS (CROCUS SATIVUS) PLANT NATIVE TO SOUTHWEST ASIA. IT HAS HISTORICALLY BEEN THE WORLD’S MOST EXPENSIVE SPICE PER UNIT WEIGHT. CHEMICAL ANALYSIS HAS SHOWN THE PRESENCE OF MORE THAN 150 COMPONENTS IN SAFFRON STIGMAS. THE MORE POWERFUL COMPONENTS OF SAFFRON ARE CROCIN, CROCETIN AND SAFRANAL. STUDIES IN ANIMAL MODELS AND WITH CULTURED HUMAN MALIGNANT CELL LINES HAVE DEMONSTRATED ANTITUMOR AND CANCER PREVENTIVE ACTIVITIES OF SAFFRON AND ITS MAIN INGREDIENTS, POSSIBLE MECHANISMS FOR THESE ACTIVITIES ARE DISCUSSED...

AN OVERVIEW OF PANCREATIC CYSTIC LESION INCIDENCE, PREVALENCE, EPIDEMIOLOGY AND NATURE IS PROVIDED. IPMN PHENOTYPES ARE DISCUSSED WITH AN EMPHASIS ON THE ROLE OF IMAGING FOR THE DIAGNOSIS, THE IDENTIFICATION OF FEATURES PREDICTIVE OF MALIGNANCY AND LESION FOLLOW-UP...

INTRODUCTION & AIM: CIRCULATING MICRORNAS ARE PROMISING BIOMARKERS IN DIAGNOSIS AND ASSESSMENT OF CANCEROUS PATIENTS. QUANTITATIVE REAL-TIME PCR ASSAY IS A SENSITIVE TEST FOR EVALUATING THE LEVELS OF MIRNAS EXPRESSION. NEVERTHELESS, THERE IS NO CONCURRENCE ON SELECTING APPROPRIATE REFERENCE GENES FOR QPCR ANALYSIS OF MIRNAS IN CIRCULATION. THEREFORE, THE CURRENT STUDY AIMED TO SELECT A SUITABLE REFERENCE GENE FOR NORMALIZING THE RT-QPCR ASSAY RESULTS IN PLASMA SAMPLES OF PATIENTS WITH GASTRIC CANCER...

MONITORING CANCER INCIDENCE AND TIME TRENDS IS ESSENTIAL FOR CANCER RESEARCHES AND HEALTH CARE PLANNING. IN SERVICE PLANNING, INDICATORS SUCH AS INCIDENCE CAN HELP DEVELOPMENT OF STRATEGIES FOR SERVICE PROVIDERS. IT IS ESTABLISHED FIGURE OF CANCER INCIDENCE WILL RISE IN FUTURE AND A MAJOR PART OF SUCH RISE ACCURSE IN DEVELOPING COUNTRIES WHERE 70% OF CANCERS RELATED DEATH WILL OCCUR. IT IS NECESSARY TO PROVIDE A CLEAR COMPARABLE FIGURE OF TRENDS IN INCIDENCE OF GI CANCERS IN IRAN. INCIDENCE DATA WAS PROVIDED BY CANCER REGISTRY SYSTEM SUPERVISED BY MOHME. THE DATA WAS ANALYZED BY EACH GI SEPARATED OVER 5 YEARS...

INTRODUCTION & AIM: WORLDWIDE, COLORECTAL CANCER (CRC) IS REPORTED TO BE THE FOURTH MOST COMMON CANCER IN MEN AND THE THIRD MOST COMMON IN WOMEN. KRAS IS A PROTOONCOGENE LOCATED ON THE SHORT ARM OF CHROMOSOME 12. THE AIM OF THIS STUDY WAS TO EVALUATE THE KRAS ONCOGENE AND ITS RELATIONSHIP IT WITH CLINICOPATHOLOGIC FEATURES IN 33 KURDISH PATIENTS...

INTRODUCTION AND AIMS: THE PRESENT INVESTIGATION WAS DESIGNED TO ASSESS THE EXPRESSION LEVELS OF DCLK1 AS A DISTINGUISHED INTESTINAL CANCER STEM CELL MARKER IN GASTRIC MALIGNANCY AND ITS CLINICAL SIGNIFICANCE IN A SERIES OF GASTRIC CANCERS (GC)...

INTRODUCTION & AIM: INCIDENCE OF COLORECTAL CANCER (CRC) IN IRAN HAS INCREASED RECENTLY; ESPECIALLY THE INCIDENCE OF THE DISEASE IN YOUNG PATIENTS IS HIGHER THAN EXPECTED. AIM OF THIS STUDY IS SURVEY ON 40 YOUNG PATIENTS WITH CRC IN KURDISH POPULATION...

A. IN RESECTABLE PANCREATIC ADENOCARCINOMAS:1. AFTER RESECTION MOST PATIENTS WILL BENEFIT FROM ADJUVANT CHEMOTHERAPY. 2. AFTER ADJUVANT CHEMOTHERAPY ADDING CHEMORADIATION IS CONTROVERSIAL – BETTER IN R1 OR N1 TUMORS.3. NEOADJUVANT TREATMENT IN RESECTABLE TUMORS MAY ADD SOME BENEFIT BUT IS STILL INVESTIGATIONAL. 4. PATIENTS WITH RESECTABLE TUMORS BUT WORSE PROGNOSIS MAY BE CANDIDATES FOR NEOADJUVANT TREATMENT...

INTRODUCTION: PANCREATIC CANCER IS THE FOURTH LEADING CAUSE OF CANCER-RELATED VESSEL. RISK FACTORS FOR PANCREATIC CANCER INCLUDE CONTACT MATERIALS, HIGH-FAT DIET WITH HIGH MEAT AND ENVIRONMENTAL TOXINS. PANCREATIC CANCER AND CHRONIC PANCREATITIS ASSOCIATED WITH DIABETES MELLITUS AND INHERITANCE...

INTRODUCTION: GASTRIC CANCER IS THE SECOND MOST COMMON CANCER IN ASIA. BECAUSE MORE THAN 50 PERCENT OF KNOWN CASES DIAGNOSIS IS INOPERABLE. DESPITE AVAILABLE TREATMENTS HAVE A HIGH CHANCE OF A LIFETIME 5-YEAR-OLD CAN NOT EXPECT THESE PEOPLE. SINCE THE PREVALENCE OF GASTRIC CANCER, THE PRESENCE OF APPROPRIATE TOOLS FOR EARLY DETECTION AND TREATMENT, THIS STUDY WAS CONDUCTED TO DETERMINE THE DIAGNOSIS AND TREATMENT OF GASTRIC CANCER...

TO EXPLORE THE CYTOTOXICITY EFFECTS OF CASPIAN COBRA (NAJA OXIANA OR N. OXIANA) VENOM ON HEPATOCYTES AND MITOCHONDRIA OBTAINED FROM THE LIVER OF HCC RATS. IN THIS STUDY, HCC INDUCED BY DIETHYLNITROSAMINE (DEN), AS AN INITIATOR, AND 2-ACETYLAMINOFLUORENE (2-AAF), AS A PROMOTER...

INTRODUCTION & AIM: COLORECTAL CANCER (CRC) IS THE THIRD MOST COMMON CANCER, AND THE FOURTH MOST COMMON CAUSE OF CANCER DEATH WORLDWIDE. APPROXIMATELY, 1.4 MILLION PEOPLE ARE DIAGNOSED WITH CRC AND 700, 000 DIE OF CRC ANNUALLY.THE ABILITY OF CANCER CELLS TO MIGRATE AND RELOCATE LEAD TO THE CREATION OF SECONDARY TUMORS ELSEWHERE IN THE BODY.COFILIN 1 IS ONE OF THE IMPORTANT PROTEINS RESPONSIBLE FOR CELL MIGRATION PROCESS AND PLAYS A KEY ROLE IN THE DYNAMICS OF ACTIN FILAMENTS. MICROTUBULE ACTINS ARE RESPONSIBLE FOR FORMING CELLS. THEY ARE ALSO ESSENTIAL IN CYTOKINESIS AND CELL MIGRATION BY CREATING REDUNDANCIES AND FALSE LEGS. COFILIN 1 IS CONSIDERED AS AN ACTIN-BINDING PROTEIN WHICH CONTROLS LOCATING, POLYMERIZATION AND DEPOLYMERIZATIONOF ACTIN MONOMERS. THE PURPOSE OF THIS STUDY, AS A CASE-CONTROL STUDY, WAS TO EXAMINE CHANGES IN COFILIN 1 GENE EXPRESSION IN PATIENTS WITH COLORECTAL CANCER...