STUDY OF THE THERAPEUTIC TREND OF COMMON MUTATIONS IN CYSTIC FIBROSIS THROUGH GENE THERAPY

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Ghanbari HasanKeadeh Saeed; mohammadzadeh Amir hosein

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Seminar Paper

Paper Information

Seminar: INTERNATIONAL CONFERENCE ON MODERN TECHNOLOGY IN SCIENCES
Year:2019 | Issue:2

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Title

STUDY OF THE THERAPEUTIC TREND OF COMMON MUTATIONS IN CYSTIC FIBROSIS THROUGH GENE THERAPY

Author(s)

Ghanbari HasanKeadeh Saeed | mohammadzadeh Amir hosein

Keywords

GENE THERAPY

CYSTIC FIBROSIS

CFTR

VECTOR

MINICIRCLE DNA

Abstract

CYSTIC FIBROSIS (CF) IS A CHRONIC AND RESPIRATORY DISEASE THAT AFFECTS MULTIPLE SYSTEMS OF THE BODY AND IS CONSIDERED TO BE THE MOST COMMON AUTOSOMAL RECESSIVE DISORDER AMONG WHITE PEOPLE. THE ONSET OF A MUTATION IN A PROTEIN GENE CALLED CFTR (CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTIVE REGULATOR) IS THE MAIN CAUSE OF THIS DISEASE. THE TYPE AND DISTRIBUTION OF MUTATIONS AMONG DIFFERENT TRIBES AND ETHNIC GROUPS IS VERY VARIABLE. BASED ON RESEARCH, PHENYLALANINE REMOVAL AT POSITION NUMBER 508 OF THE CFTR PROTEIN (Δ F508) IS THE MOST COMMON MUTATION IN THE DISEASE. AS A RESULT, RECENT ADVANCES IN CF TREATMENT HAVE FOCUSED ON CORRECTING DEFECTIVE CFTR PROTEIN FUNCTION. LIFE EXPECTANCY IN CF PATIENTS OVER THE LAST FEW YEARS HAS INCREASED DUE TO BETTER UNDERSTANDING OF THE DISEASE AND TREATMENTS AIMED AT COMPLETELY ERADICATING THE DISEASE, AND SIGNIFICANT EFFORTS HAVE BEEN MADE IN GENE THERAPY TO FIND AN INDEPENDENT TREATMENT FOR CF. IN THIS STUDY, EFFORTS TO ADVANCE GENE THERAPY AND REMAINING CHALLENGES WILL BE EVALUATED THROUGH THE ANALYSIS OF VIRAL AND NON-VIRAL VECTORS AS WELL AS RECENT ADVANCES IN THE DEVELOPMENT OF GENES THROUGH THE USE OF MINICIRCLES DNA AND SPECIFIC MUTATED MOLECULES.

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APA: Copy

Ghanbari HasanKeadeh, Saeed, & mohammadzadeh, Amir hosein. (2019). STUDY OF THE THERAPEUTIC TREND OF COMMON MUTATIONS IN CYSTIC FIBROSIS THROUGH GENE THERAPY. INTERNATIONAL CONFERENCE ON MODERN TECHNOLOGY IN SCIENCES. SID. https://sid.ir/paper/949169/en

Vancouver: Copy

Ghanbari HasanKeadeh Saeed, mohammadzadeh Amir hosein. STUDY OF THE THERAPEUTIC TREND OF COMMON MUTATIONS IN CYSTIC FIBROSIS THROUGH GENE THERAPY. 2019. Available from: https://sid.ir/paper/949169/en

IEEE: Copy

Saeed Ghanbari HasanKeadeh, and Amir hosein mohammadzadeh, “STUDY OF THE THERAPEUTIC TREND OF COMMON MUTATIONS IN CYSTIC FIBROSIS THROUGH GENE THERAPY,” presented at the INTERNATIONAL CONFERENCE ON MODERN TECHNOLOGY IN SCIENCES. 2019, [Online]. Available: https://sid.ir/paper/949169/en

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