Transplantation of Mesenchymal Stem Cells for Diabetic Ulcer in Animal Model

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Zare Sona; Ahmadi Rahim; NILFOROUSHZADEH MOHAMMAD ALI; MOHAMADNIA ABDOLREZA; MANSOURI PARVIN; MAHMOODI MINOO; GHAHARY AZIZ; Peyrovan Aysan; Kazemzadeh Fatemeh

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Seminar: CONGRESS OF WOUND AND TISSUE REPAIR
Year:2019 | Issue:6

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Title

Transplantation of Mesenchymal Stem Cells for Diabetic Ulcer in Animal Model

Author(s)

Keywords

Mesenchymal Stem Cells

Cell Therapy

Wound Healing

Abstract

Mesenchymal Stem Cells derived from human adipose tissue are novel therapeutic technology and more topical than ever. Here we evaluated the effects of cells of adipose on Wound Healing in an in vivo diabetic rat model. Materials and methods We injected intradermal and sprayed MSCs in skin wounds in diabetic rat and evaluated Wound Healing parameters. In 7, 14 and 21 days, we compared the percent of wound closure, pathologic staining, biometric and mechanical analysis and the angiogenic potential between two groups. Results Two groups significantly induced a faster healing and a higher number of blood vessels in the wound when compared to controls (Normal saline injection). Biometric and mechanical data and image J software analysis showed we have good treatment. Conclusion Results indicate that two groups exert similar beneficial effects on wound closure and neovascularization in our rat model. Using spray device as carrier for MSCs propagates rapid cell migration towards the wound area that allows a fast and clinically practicable method for stem cells application.

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APA: Copy

Zare, Sona, Ahmadi, Rahim, NILFOROUSHZADEH, MOHAMMAD ALI, MOHAMADNIA, ABDOLREZA, MANSOURI, PARVIN, MAHMOODI, MINOO, GHAHARY, AZIZ, Peyrovan, Aysan, & Kazemzadeh, Fatemeh. (2019). Transplantation of Mesenchymal Stem Cells for Diabetic Ulcer in Animal Model. 4ST INTERNATIONAL AND 6RD NATIONAL CONGRESS OF WOUND AND TISSUE REPAIR (the future of wounds and sca. SID. https://sid.ir/paper/949188/en

Vancouver: Copy

Zare Sona, Ahmadi Rahim, NILFOROUSHZADEH MOHAMMAD ALI, MOHAMADNIA ABDOLREZA, MANSOURI PARVIN, MAHMOODI MINOO, GHAHARY AZIZ, Peyrovan Aysan, Kazemzadeh Fatemeh. Transplantation of Mesenchymal Stem Cells for Diabetic Ulcer in Animal Model. 2019. Available from: https://sid.ir/paper/949188/en

IEEE: Copy

Sona Zare, Rahim Ahmadi, MOHAMMAD ALI NILFOROUSHZADEH, ABDOLREZA MOHAMADNIA, PARVIN MANSOURI, MINOO MAHMOODI, AZIZ GHAHARY, Aysan Peyrovan, and Fatemeh Kazemzadeh, “Transplantation of Mesenchymal Stem Cells for Diabetic Ulcer in Animal Model,” presented at the 4ST INTERNATIONAL AND 6RD NATIONAL CONGRESS OF WOUND AND TISSUE REPAIR (the future of wounds and sca. 2019, [Online]. Available: https://sid.ir/paper/949188/en

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