ANALGESIC EFFECT OF CHLORPHENIRAMINE IN RAT ANESTHESIA WITH ACEPROMAZINE –KETAMINE COMBINATION

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Hajighahramani Shahin; Mojtahedin Ali; GHARIB KHAJE VAHID

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Journal: Pars Journal of Medical Sciences Year:2016 | Volume:14 | Issue:3 Page(s): 18-26

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Title

ANALGESIC EFFECT OF CHLORPHENIRAMINE IN RAT ANESTHESIA WITH ACEPROMAZINE –KETAMINE COMBINATION

Author(s)

Hajighahramani Shahin | Mojtahedin Ali | GHARIB KHAJE VAHID | Issue Writer Certificate

Keywords

CHLORPHENIRAMINEQ2

ACEPROMAZINEQ1

KETAMINEQ2

ANESTHESIAQ3

RATQ2

ANTINOCICEPTIONQ1

Abstract

Introduction: Recently, antihistamines have been considered as analgesic agents. The present study aimed to investigate the analgesic function of CHLORPHENIRAMINE combined with ACEPROMAZINE-ketamine during ANESTHESIA and surgery in RATs.Methods & Materials: Twenty adult RATs were randomly assigned to two groups. The first group received CHLORPHENIRAMINE and 30 minutes later ACEPROMAZINE–ketamine. The second group received normal saline initially and 30 minutes later ACEPROMAZINE-ketamine. Pain reflexes were assessed by toe pinch test, tail pinch test and RATs’ reflex to laparotomy during ANESTHESIA. Induction time, light ANESTHESIA duration, surgical ANESTHESIA time, walking time, heart RATe and respiratory RATe were measured.Results: Duration of light ANESTHESIA was shorter in group 2 than in group 1 (P<0.05). Laparotomy pain score was significantly less in group 1. Toe pinch and tail pinch tests were not significantly different between the two groups. Heart RATe was not significantly different between the two groups.Conclusion: As a pre-anesthesia medication, CHLORPHENIRAMINE induces appropriate ANESTHESIA in RATs in combination with ACEPROMAZINE-ketamine. Thus, CHLORPHENIRAMINE can be used in RATs as a preanesthesia medication for surgical operations in combination with ACEPROMAZINE-ketamine.

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APA: Copy

Hajighahramani, Shahin, Mojtahedin, Ali, & GHARIB KHAJE, VAHID. (2016). ANALGESIC EFFECT OF CHLORPHENIRAMINE IN RAT ANESTHESIA WITH ACEPROMAZINE –KETAMINE COMBINATION. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), 14(3 ), 18-26. SID. https://sid.ir/paper/130848/en

Vancouver: Copy

Hajighahramani Shahin, Mojtahedin Ali, GHARIB KHAJE VAHID. ANALGESIC EFFECT OF CHLORPHENIRAMINE IN RAT ANESTHESIA WITH ACEPROMAZINE –KETAMINE COMBINATION. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL)[Internet]. 2016;14(3 ):18-26. Available from: https://sid.ir/paper/130848/en

IEEE: Copy

Shahin Hajighahramani, Ali Mojtahedin, and VAHID GHARIB KHAJE, “ANALGESIC EFFECT OF CHLORPHENIRAMINE IN RAT ANESTHESIA WITH ACEPROMAZINE –KETAMINE COMBINATION,” PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), vol. 14, no. 3 , pp. 18–26, 2016, [Online]. Available: https://sid.ir/paper/130848/en

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