RADIOLABELING QUALITY CONTROL AND BIODISTRIBUTION STUDY OF ANTI-CD20 ANTIBODY BY 67GA

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

JALILIAN A.R.; MIRSADEGH L.; KHORAMI A.R.; MORADKHANI S.; NASERIAN B.; DANESHVARI S.; SHADANPOUR N.; GHAHRAMAN H.; HAJI HOSSEINI REZA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY Year:2009 | Volume:- | Issue:4 (46) Page(s): 10-17

Download Full-Text

Persian Verion

View:

827

Download:

Cites:

Information Journal Paper

Title

RADIOLABELING QUALITY CONTROL AND BIODISTRIBUTION STUDY OF ANTI-CD20 ANTIBODY BY 67GA

Author(s)

Keywords

ANTI-CD20Q3

DOTAQ3

67GAQ3

RITUXIMABQ3

CYCLOTRONQ2

QUALITY CONTROLQ3

BIODISTRIBUTIONQ2

LABELINGQ3

RADIOISOTOPE PRODUCTIONQ2

Abstract

Nowadays, ANTI-CD20 antibodies are being used in the therapy of lymphomas in free or radiolabeled form. Conjugation process was performed using native antibody and DOTA-NHS compound, synthesized in our laboratory. Thin layer chromatography and gel filtration were used to control the reaction progress as well as purification of the final antibody conjugate. 67GACl3 produced at AMIRS was used to label the immunoconjugate and the reaction conditions were optimized for time, temperature and reactant concentrations. QUALITY CONTROL of the radioimmunoconjugate was performed using RTLC and gel filtration. The radiochemical purity was shown to be over 95%. The radioimmunoconjugate was used in the BIODISTRIBUTION studies up to 28 h and it was shown that after 24h most of the activity was accumulated in reticuloendothelial system consisting liver and spleen.

Cites

No record.

References

No record.

Cite

APA: Copy

JALILIAN, A.R., MIRSADEGH, L., KHORAMI, A.R., MORADKHANI, S., NASERIAN, B., DANESHVARI, S., SHADANPOUR, N., GHAHRAMAN, H., & HAJI HOSSEINI, REZA. (2009). RADIOLABELING QUALITY CONTROL AND BIODISTRIBUTION STUDY OF ANTI-CD20 ANTIBODY BY 67GA. JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY, -(4 (46)), 10-17. SID. https://sid.ir/paper/97639/en

Vancouver: Copy

JALILIAN A.R., MIRSADEGH L., KHORAMI A.R., MORADKHANI S., NASERIAN B., DANESHVARI S., SHADANPOUR N., GHAHRAMAN H., HAJI HOSSEINI REZA. RADIOLABELING QUALITY CONTROL AND BIODISTRIBUTION STUDY OF ANTI-CD20 ANTIBODY BY 67GA. JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY[Internet]. 2009;-(4 (46)):10-17. Available from: https://sid.ir/paper/97639/en

IEEE: Copy

A.R. JALILIAN, L. MIRSADEGH, A.R. KHORAMI, S. MORADKHANI, B. NASERIAN, S. DANESHVARI, N. SHADANPOUR, H. GHAHRAMAN, and REZA HAJI HOSSEINI, “RADIOLABELING QUALITY CONTROL AND BIODISTRIBUTION STUDY OF ANTI-CD20 ANTIBODY BY 67GA,” JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY, vol. -, no. 4 (46), pp. 10–17, 2009, [Online]. Available: https://sid.ir/paper/97639/en

Related Journal Papers