PRODUCTION OF ROBIDIOM-81 FOR INTRAVENOUS INJECTION, QUALITY CONTROL & BIOLOGICAL ASSESSMENT

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JALALIAN A.R.; KIOUMARSI M.; MIRZAEI MOHAMMAD; ROUSHAN FARZAD P.; KARIMIAN A.R.; MOTAMEDI SADEH F.; MORADKHANI S.; ABOUDZADEH M.R.

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Journal: IRANIAN JOURNAL OF MEDICAL PHYSICS Year:2003 | Volume:1 | Issue:2 Page(s): 23-28

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Title

PRODUCTION OF ROBIDIOM-81 FOR INTRAVENOUS INJECTION, QUALITY CONTROL & BIOLOGICAL ASSESSMENT

Author(s)

Keywords

ROBIDIUMQ4

CYCLOTRONQ4

RADIOISOTOPEQ4

Abstract

Introduction: -81 is routinely produced almost everywhere in the world. This is a gamma and positron emitter RADIOISOTOPE, which may potentially be used for PET and SPECT imaging. However it is mainly used in Rubidium-Krypton generator. In this study a soluble compound of Rubidium that is suitable for intravenous injection was produced. The product was biologically evaluated.Methods and Materials: Rubidium was produced in CYCLOTRON using proton bombardments. The purity of the final product was measured using chromatographic and spectroscopic methods. The product was formulate9 and injected to the rates to determine the biological distribution.Results: The chemical and radioisotopic purity of the product was acceptable. The optimum time for imaging was found to be three hours after injection.Conclusion: Our results proved that the product is suitable for clinical investigation. Our center is capable of weekly production of isotope.

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References

گزینش واکنش هسته ای مناسب برای تولدی رادیوداروی کریپتون -81m

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APA: Copy

JALALIAN, A.R., KIOUMARSI, M., MIRZAEI, MOHAMMAD, ROUSHAN FARZAD, P., KARIMIAN, A.R., MOTAMEDI SADEH, F., MORADKHANI, S., & ABOUDZADEH, M.R.. (2003). PRODUCTION OF ROBIDIOM-81 FOR INTRAVENOUS INJECTION, QUALITY CONTROL & BIOLOGICAL ASSESSMENT. IRANIAN JOURNAL OF MEDICAL PHYSICS, 1(2), 23-28. SID. https://sid.ir/paper/96890/en

Vancouver: Copy

JALALIAN A.R., KIOUMARSI M., MIRZAEI MOHAMMAD, ROUSHAN FARZAD P., KARIMIAN A.R., MOTAMEDI SADEH F., MORADKHANI S., ABOUDZADEH M.R.. PRODUCTION OF ROBIDIOM-81 FOR INTRAVENOUS INJECTION, QUALITY CONTROL & BIOLOGICAL ASSESSMENT. IRANIAN JOURNAL OF MEDICAL PHYSICS[Internet]. 2003;1(2):23-28. Available from: https://sid.ir/paper/96890/en

IEEE: Copy

A.R. JALALIAN, M. KIOUMARSI, MOHAMMAD MIRZAEI, P. ROUSHAN FARZAD, A.R. KARIMIAN, F. MOTAMEDI SADEH, S. MORADKHANI, and M.R. ABOUDZADEH, “PRODUCTION OF ROBIDIOM-81 FOR INTRAVENOUS INJECTION, QUALITY CONTROL & BIOLOGICAL ASSESSMENT,” IRANIAN JOURNAL OF MEDICAL PHYSICS, vol. 1, no. 2, pp. 23–28, 2003, [Online]. Available: https://sid.ir/paper/96890/en

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