Production of 177Lu in No Carrier Added (NCA) form by Irradiation of Natural and Enriched Target in Tehran Research Reactor for Nuclear Medicine Approch

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Salek n.; SHAMSAEI ZAFARGHANDI M.; SHIRVANI ARANI S.; BAHRAMI SAMANI A.; GHANNADI MARAGHEH M.

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Journal: JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY Year:2016 | Volume:- | Issue:77 Page(s): 1-8

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Title

Production of 177Lu in No Carrier Added (NCA) form by Irradiation of Natural and Enriched Target in Tehran Research Reactor for Nuclear Medicine Approch

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Keywords

RadiotherapyQ2

No-Carrier Added (NCA)Q1

LutethiumQ1

LabelingQ2

Abstract

177Lu owing to its favorable nuclidic characteristics, such as tl/2=6/73d and Eβ (max)= 497 keV and ease of its large-scale production using medium flux research reactors, is an attractive radionuclide for various therapeutic applications. In this study 177Lu with the radionuclide purity of >99. 9% was obtained by thermal neutron bombardment (4×1013n/cm2. s) of 176Yb target through the 176Yb(n, γ ) 177Yb      177Lu process. The method of separation of 177Lu from macro amount of Yb target was based on extraction chromatographic (EXC). The extractant used in resin was di(2-ethylhexyl) orthophosphoric acid (HDEHP). Finally, (177Lu) with a specific activity of 230. 1 MBq (6. 22 mCi) was prepared without the addiation of any carrier radionuclide. The process provides a separation yield of 75% 177Lu and a decontamination factor of 2000. The whole process to prepare NCA 177Lu takes almost 1. 5 hours. The resultant NCA 177Lu can be used for preparation of NCA 177Lu labeled radiotherapeuticals.

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APA: Copy

Salek, n., SHAMSAEI ZAFARGHANDI, M., SHIRVANI ARANI, S., BAHRAMI SAMANI, A., & GHANNADI MARAGHEH, M.. (2016). Production of 177Lu in No Carrier Added (NCA) form by Irradiation of Natural and Enriched Target in Tehran Research Reactor for Nuclear Medicine Approch. JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY, -(77 ), 1-8. SID. https://sid.ir/paper/97816/en

Vancouver: Copy

Salek n., SHAMSAEI ZAFARGHANDI M., SHIRVANI ARANI S., BAHRAMI SAMANI A., GHANNADI MARAGHEH M.. Production of 177Lu in No Carrier Added (NCA) form by Irradiation of Natural and Enriched Target in Tehran Research Reactor for Nuclear Medicine Approch. JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY[Internet]. 2016;-(77 ):1-8. Available from: https://sid.ir/paper/97816/en

IEEE: Copy

n. Salek, M. SHAMSAEI ZAFARGHANDI, S. SHIRVANI ARANI, A. BAHRAMI SAMANI, and M. GHANNADI MARAGHEH, “Production of 177Lu in No Carrier Added (NCA) form by Irradiation of Natural and Enriched Target in Tehran Research Reactor for Nuclear Medicine Approch,” JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY, vol. -, no. 77 , pp. 1–8, 2016, [Online]. Available: https://sid.ir/paper/97816/en

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