SYNTHESIS OF A BIPHOSPHONATE (HEDP) AS A BONE IMAGING AGENT WITH 99MTC

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SHAABANI GH.A.; ABD ELAHPOUR M.; NAJAFI REZA

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Journal: JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY Year:2007 | Volume:- | Issue:3 (41) Page(s): 9-14

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Title

SYNTHESIS OF A BIPHOSPHONATE (HEDP) AS A BONE IMAGING AGENT WITH 99MTC

Author(s)

SHAABANI GH.A. | ABD ELAHPOUR M. | NAJAFI REZA | Issue Writer Certificate

Keywords

SYNTHESIS OF BIPHOSPHONATEQ3

HEDPQ3

FTIRQ3

NMRQ2

BONE SCANQ3

99MTCQ3

Abstract

In the last three decades, 99mTc-MDPand 99mTc-HEDPhave been used as diagnostic radiophannaceuticals for bone imaging agents. The radioisotope Department after many investigations decided to develop the synthesis of a biphosphonate derivative, named l-hydroxy-ethylidene-l, l-disodium phosphonate. (HEDP). In this article, we discuss the method of synthesis, formulation, and labeling of lyophilised kit with 99mTc. The results show that our kit has a high radiochemical purity (>95%), according to the US pharmacopeia. In addition, the stability of lyophilised HEDP kit is more than one year at 4-8°C.

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APA: Copy

SHAABANI, GH.A., ABD ELAHPOUR, M., & NAJAFI, REZA. (2007). SYNTHESIS OF A BIPHOSPHONATE (HEDP) AS A BONE IMAGING AGENT WITH ^99MTC. JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY, -(3 (41)), 9-14. SID. https://sid.ir/paper/97922/en

Vancouver: Copy

SHAABANI GH.A., ABD ELAHPOUR M., NAJAFI REZA. SYNTHESIS OF A BIPHOSPHONATE (HEDP) AS A BONE IMAGING AGENT WITH ^99MTC. JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY[Internet]. 2007;-(3 (41)):9-14. Available from: https://sid.ir/paper/97922/en

IEEE: Copy

GH.A. SHAABANI, M. ABD ELAHPOUR, and REZA NAJAFI, “SYNTHESIS OF A BIPHOSPHONATE (HEDP) AS A BONE IMAGING AGENT WITH ^99MTC,” JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY, vol. -, no. 3 (41), pp. 9–14, 2007, [Online]. Available: https://sid.ir/paper/97922/en

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