Production and Quality Control of Indium-111 Pentetreotide Radiopharmaceutical in Iran

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Fazaeli Hoseini Nezhad S.Y.; ERFANI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY Year:2017 | Volume:- | Issue:80 Page(s): 25-34

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Title

Production and Quality Control of Indium-111 Pentetreotide Radiopharmaceutical in Iran

Author(s)

Fazaeli Hoseini Nezhad S.Y. | ERFANI M. | Issue Writer Certificate

Keywords

111In PentetreotideQ1

SomatostatinQ1

Theranostic AgentQ1

Neuroendocrine TumorsQ1

Abstract

111In Pentetreotide (OctreoScanTM) radiopharmaceutical is used extensively for the detection of a variety of cancers in medicine. Octerotide is a pharmaceutical with a structure similar to Somatostatin which is administrated via intravenous injection in an 111In labeled form. This radiopharmaceutical acts as a Theranostic Agent with binding to Somatostatin receptors. Over the last decade, 111In Pentetreotide has remained the most widely used radiopharmaceutical for the scintigraphic detection and staging of primary and metastatic Neuroendocrine Tumors. In this study, application of this radiopharmaceutical as well as the production and quality control strategies was investigated precisely. Briefly, the labeling yield of 111In Pentetreotide was determined before the administration to the rodents. The incorporation of the radionuclide was measured by RTLC and the radiochemical purity was measured by HPLC. Due to the high thermodynamic stability constants for DTPA and In3+, the formation yield of 111In Pentetreotide under the terms applied in this study was found to be high.

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APA: Copy

Fazaeli Hoseini Nezhad, S.Y., & ERFANI, M.. (2017). Production and Quality Control of Indium-111 Pentetreotide Radiopharmaceutical in Iran. JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY, -(80 ), 25-34. SID. https://sid.ir/paper/97954/en

Vancouver: Copy

Fazaeli Hoseini Nezhad S.Y., ERFANI M.. Production and Quality Control of Indium-111 Pentetreotide Radiopharmaceutical in Iran. JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY[Internet]. 2017;-(80 ):25-34. Available from: https://sid.ir/paper/97954/en

IEEE: Copy

S.Y. Fazaeli Hoseini Nezhad, and M. ERFANI, “Production and Quality Control of Indium-111 Pentetreotide Radiopharmaceutical in Iran,” JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY, vol. -, no. 80 , pp. 25–34, 2017, [Online]. Available: https://sid.ir/paper/97954/en

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