Effect of training and creatine supplementation interaction on insulin resistance and glucose tolerance in obese male rats

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Parsa Hesam; Zareie Morteza

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Journal Paper

Paper Information

Journal: Journal of Sport and Exercise Physiology Year:2022 | Volume:15 | Issue:1 Page(s): 83-96

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Information Journal Paper

Title

Effect of training and creatine supplementation interaction on insulin resistance and glucose tolerance in obese male rats

Author(s)

Parsa Hesam | Zareie Morteza | Issue Writer Certificate

Keywords

Creatine

Swimming

Insulin resistance

Glucose tolerance

High-fat diet

Obesity

Abstract

Purpose: The present study was undertaken to explore the effects of exercise training and Creatine supplementation interaction on Insulin resistance and Glucose tolerance in obese male rats. Methods: 50 male Wistar rats (weigh,160 ±,15 g) were randomly divided into five groups. Control, High-fat diet, High-fat diet plus Creatine supplementation, High-fat diet plus exercise training and High-fat diet plus Creatine plus exercise training. Training program was 12 weeks Swimming and each week its duration increased. At the end, rats underwent the Glucose tolerance test (OGTT) and the blood samples for analyzing TG, HDL and insulin collected. Moreover, for determining of PGC-1α,expression the SOL muscle dissected. Results: Obesity resulted in increased Insulin resistance level and it also reduced Glucose tolerance and insulin efficiency,Creatine supplementation alone did not affect these changes. Training reduced Insulin resistance and also elevated Glucose tolerance and insulin efficiency in high-fat fed rats and Creatine supplementation combined with training had additive effect on these variables. High-fat diet reduced PGC-1α,protein level and training elevated it. Creatine supplementation alone or combined with training did not change the expression of this protein (P < 0. 05). Conclusion: For the first time, this study shows that combined Creatine supplementation with training resulted in improved glycemic control and insulin efficiency and it also reduced the Insulin resistance of obese rats.

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APA: Copy

Parsa, Hesam, & Zareie, Morteza. (2022). Effect of training and creatine supplementation interaction on insulin resistance and glucose tolerance in obese male rats. PHYSIOLOGY OF SPORT AND PHYSICAL ACTIVITY, 15(1 ), 83-96. SID. https://sid.ir/paper/999867/en

Vancouver: Copy

Parsa Hesam, Zareie Morteza. Effect of training and creatine supplementation interaction on insulin resistance and glucose tolerance in obese male rats. PHYSIOLOGY OF SPORT AND PHYSICAL ACTIVITY[Internet]. 2022;15(1 ):83-96. Available from: https://sid.ir/paper/999867/en

IEEE: Copy

Hesam Parsa, and Morteza Zareie, “Effect of training and creatine supplementation interaction on insulin resistance and glucose tolerance in obese male rats,” PHYSIOLOGY OF SPORT AND PHYSICAL ACTIVITY, vol. 15, no. 1 , pp. 83–96, 2022, [Online]. Available: https://sid.ir/paper/999867/en

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