In the current era, human-rights regional organizations, while enjoying appropriate human rights mechanisms, have often placed their priority in monitoring the human rights situation in member states and taking appropriate measures to deal with human rights violations in these countries. In recent years, the Organization of Islamic Cooperation, as a regional institution, has seen developments in the field of human rights that can be considered in the form of provision of human rights documents and the designing minimum mechanisms for the promotion of human rights in Islamic states. In addition to the quality of considering the human rights by the organization, this article will examine whether the approach of Organization of Islamic Cooperation has been extrinsic or intrinsic in concern with the documents of human rights and procedure of the organization. Finally, it is concluded the documents and procedure of the organization reveal that it has taken an extrinsic approach with an emphasis on the human rights situation of Muslims in non-member countries; meanwhile besides departing from the traditional approach of the organization, the recent approach to monitoring the human rights situation in some member states is indicative of a tendency towards an intrinsic approach to human rights. However, the organization's discriminatory response to human rights violations in member states is a major concern.