The objective of the current study was to assess the ethanolic and methanolic extracts of Carica papaya's hypoglycemic effects. Yeast glucose uptake, muscle glucose uptake, and glucose adsorption capacity were used to measure the extracts' in vitro hypoglycemic effects. The antioxidant capacity of the extracts was assessed by investigating how they affect lipid peroxidation brought on by iron (II) sulphate and sodium nitroprusside. The findings showed that glucose was absorbed by both the ethanolic and methanolic extracts of Carica papaya, and that this adsorption significantly increased as the concentration of glucose rose. There were no variations in their adsorption capabilities that were statistically significant (p=0.05). The yeast cells were also stimulated to take up glucose by the plant extracts, and this stimulation was influenced by the sample and glucose content. In the study's muscle glucose uptake, the ethanolic extract of Carica papaya leaves showed substantially greater (p=0.05) performance than the methanolic of the same leaves with increasing concentration. The study's findings showed that the plant's methanolic extract was substantially more potent than its ethanolic (p=0.05). In addition, the methanolic extract considerably inhibited the generation of MDA (malondialdehyde) in the liver and brain homogenates more than the ethanolic extract did. Both plant extracts also exhibit dose-dependent inhibition of the various pro-oxidant agents (Iron (II) Sulphate and sodium nitroprusside) caused fatty acid oxidation tissues present in the brain and liver.

Infusions of Citrullus colocynthis Schrad. (Cucurbitaceae) fruits are traditionally used as antidiabetic medication in Mediterranean countries, but to our knowledge, no studies have been undertaken so far to determine the possible mechanisms involved in the antidiabetic properties of the fruit. The present study was designed to investigate whether these fruits possess hypoglycemic effects. For this purpose, prepared suspension from C.C fruit (curcubitacea) was investigated in normal 12 h fasting rats. Blood glucose was determined before and 1, 2, 3, 4, 6, 8, 12, and 24 hours after single oral administration of prepared drug in the doses of 10, 30, 90 mg/kg. Single oral administration of prepared drug in the dose of 30 mg/kg, decreased level of BG by 18%, 24% at 4, 6 h, as compared with the control animals. Such effects of drug were not pronounced in the doses of 10 mg/kg, 90 mg/kg at 0, 4, 6, and 12 h. In conclusion, our results show that Citrullus colocynth fruit suspension have a hypoglycemic effect in the dose of 30 mg/kg, which could at least partially account for the antidiabetic activities of these fruits.