The rise of the Safavid government was not only a turning point in the field of political unity, but also the unity of Iranian-Islamic culture, especially the Shiism of the Twelve Imams, which for Islamic philosophy was the emergence of transcendental wisdom, which was not only an independent identity from Western philosophy, but also the result of Ibn Sina's interpretation of the supernatural, which Mirdamad connected it with the popular thought of the time (Shia religion) to once again bring the growth and prosperity of intellectual and theological reflections in the modern school of Isfahan to its peak. Undoubtedly, the actions of Mirdamad and his students, including Mulla Sadra Shirazi, in spite of the opposition of the superficial and religious He considered extremes to be a great service, so that he turned Isfahan into one of the important scientific centers of that time, so that hundreds of metals were cultivated at that time, which was equal to the golden age of Athens. The main purpose of the research is to investigate and analyze the philosophical school of Isfahan with an emphasis on Mulla Sadra's thought, which was written in a descriptive-analytical way and citing Safavid era sources. The findings of the research show that the rise of the Safavid government and the provision of the ground for the officialization of the Shiite religion have contributed significantly to the development of the intellectual sciences of that time, especially Islamic philosophy.