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Information Journal Paper

Title

STUDIES ON POTENTIAL MUTAGENIC AND GENOTOXIC ACTIVITY OF SETARUD

Pages

  223-228

Abstract

 Background: SETARUD (IMODTM) is a new herbal drug that has demonstrated immune modulating activity in preliminary investigations. The aim of this study was to evaluate the potential of MUTAGENICITY and genotoxic properties of SETARUD following the guidelines of the Organization for Economic Co-operation and Development (OECD) for the Testing of Chemicals. Methods: Ames Salmonella/mammalian micro some mutagenesis assay was used to evaluate the ability of the drug and its metabolites to induce mutation in Salmonella tester strains. SETARUD was applied in concentrations of 0.1-1000m/dish. The effect of the drug metabolites which were formed in the presence of rat liver microsomal fraction S9 was investigated using complete and incomplete microsomal activation mixtures, separately. Induction of DOMINANT LETHAL MUTATIONS in spermatogenic stem cells of male mice was also assessed. Results: In the Ames test, the drug preparation did not cause a significant increase in the number of revertant bacterial colonies as compared with negative control meaning that SETARUD within the tested range did not exhibit mutagenic activity. The level of post implantation losses and as a result the number of lethal mutations in germ cells at different stages of spermatogenesis in mice treated with SETARUD was not statistically higher than that of control. Conclusion: Under experimental conditions which were employed, the drug was not mutagenic or genotoxic.

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    APA: Copy

    KHORAM KHOURSHID, H.R., NOVITSKY, Y.A., ABDOLLAHI, M., SHAH HOSSEINI, MOHAMMAD HASAN, SADEGHI, B., MADANI, H., FARZAMFAR, B., & RAHIMI, R.. (2008). STUDIES ON POTENTIAL MUTAGENIC AND GENOTOXIC ACTIVITY OF SETARUD. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 16(4), 223-228. SID. https://sid.ir/paper/275480/en

    Vancouver: Copy

    KHORAM KHOURSHID H.R., NOVITSKY Y.A., ABDOLLAHI M., SHAH HOSSEINI MOHAMMAD HASAN, SADEGHI B., MADANI H., FARZAMFAR B., RAHIMI R.. STUDIES ON POTENTIAL MUTAGENIC AND GENOTOXIC ACTIVITY OF SETARUD. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2008;16(4):223-228. Available from: https://sid.ir/paper/275480/en

    IEEE: Copy

    H.R. KHORAM KHOURSHID, Y.A. NOVITSKY, M. ABDOLLAHI, MOHAMMAD HASAN SHAH HOSSEINI, B. SADEGHI, H. MADANI, B. FARZAMFAR, and R. RAHIMI, “STUDIES ON POTENTIAL MUTAGENIC AND GENOTOXIC ACTIVITY OF SETARUD,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 16, no. 4, pp. 223–228, 2008, [Online]. Available: https://sid.ir/paper/275480/en

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