EFFECTS OF CITRUS POLYMETHOXY FLAVONE TANGERETIN ON CANCER CELLS INFLAMMATORY PATHWAYS

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EBRAHIMPOUR KOUJAN S.; POURGHASSEM GARGARI B.

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Journal: NUTRITION AND FOOD SCIENCES RESEARCH Year:2014 | Volume:1 | Issue:SUPPL. (1) Page(s): 99-99

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Title

EFFECTS OF CITRUS POLYMETHOXY FLAVONE TANGERETIN ON CANCER CELLS INFLAMMATORY PATHWAYS

Author(s)

EBRAHIMPOUR KOUJAN S. | POURGHASSEM GARGARI B. | Issue Writer Certificate

Keywords

TANGERETIN

CITRUS

CANCER

INFLAMMATION

CYTOKINE

Abstract

Background: Polymethoxylated flavonoid “TANGERETIN” (5, 6, 7, 8, 40-pentamethoxyflavone) is concentrated naturally in the peel of CITRUS fruits. TANGERETIN as an antioxidant exhibit many tumor growth suppressive effects such as anti-proliferative, anti-invasive, anti-metastatic, and antioxidant activities.However, CANCER is condition that many inflammatory pathways over activation are critically involves in its initiation, promotion and progression. Thus, safe, inexpensive, and effective new treatments are needed toward inflammatory process in CANCER. The aim of this article is surveying the effects of TANGERETIN on CANCER cells inflammatory pathways.Methods: This article is a review on articles published in googlescolar and pubmed since 2000.Results: Based on evidences from experimental studies, CYTOKINEs such as IL-1b induces the activation of ERK, p38 MAPK, JNK, and AKT signaling pathways and COX-2 expression in CANCERous cells. TANGERETIN exerts inhibitory activity against many inflammatory CYTOKINEs and signal transduction. It inhibite extracellularsignalregulated kinases 1/2 (ERK1/2) phosphorylation, Cdk2 and 4 kinase activities, and increase the content of the Cdk inhibitor p21 protein that arrest the cell cycle in critical check points and suppress the tumor cells proliferation and sensitize to apoptosis. Pretreatment of tumor cells with TANGERETIN inhibited IL-1b-induced p38 MAPK, JNK, and AKT phosphorylation and suppress the COX-2 mRNA gene expression that led to the down regulation the NF-kB signaling pathways, and many inflammatory proteins and CYTOKINEs in tumors.Conclusion: The present review summarizes the anti-inflammatory effects of TANGERETIN on CANCER cells. TANGERETIN as a natural component in CITRUS especially in pells is strong antioxidant that modulates various inflammatory pathways in CANCER. It can be used as one source of candidates for the new pharmaceutical drugs is a long list of traditional medicines. To sum it up, TANGERETIN can potentially control the INFLAMMATION, but further studies needed to warranting chemopreventive and therapeutic application of TANGERETIN in humans.

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APA: Copy

EBRAHIMPOUR KOUJAN, S., & POURGHASSEM GARGARI, B.. (2014). EFFECTS OF CITRUS POLYMETHOXY FLAVONE TANGERETIN ON CANCER CELLS INFLAMMATORY PATHWAYS. NUTRITION AND FOOD SCIENCES RESEARCH, 1(SUPPL. (1)), 99-99. SID. https://sid.ir/paper/342418/en

Vancouver: Copy

EBRAHIMPOUR KOUJAN S., POURGHASSEM GARGARI B.. EFFECTS OF CITRUS POLYMETHOXY FLAVONE TANGERETIN ON CANCER CELLS INFLAMMATORY PATHWAYS. NUTRITION AND FOOD SCIENCES RESEARCH[Internet]. 2014;1(SUPPL. (1)):99-99. Available from: https://sid.ir/paper/342418/en

IEEE: Copy

S. EBRAHIMPOUR KOUJAN, and B. POURGHASSEM GARGARI, “EFFECTS OF CITRUS POLYMETHOXY FLAVONE TANGERETIN ON CANCER CELLS INFLAMMATORY PATHWAYS,” NUTRITION AND FOOD SCIENCES RESEARCH, vol. 1, no. SUPPL. (1), pp. 99–99, 2014, [Online]. Available: https://sid.ir/paper/342418/en

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