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Information Journal Paper

Title

EFFECT OF SEPTIMEBTM AS A NEW NATURAL EXTRACT ON SEVERE SEPSIS: A RANDOMIZED CLINICAL TRIAL

Pages

  35-43

Abstract

 Background: SEPTIMEB as a herbal medicine has regulatory effects on inflammation. This study set to evaluate the effects of SEPTIMEB among patients with SEPSIS on inflammatory biomarkers and survival rate.Methods: In this randomized clinical trial, 51 patients with SEPSIS from the ICU and medical ward of Imam Khomeini Hospital were divided into two groups: SEPTIMEB (n=25) and control group (n=26). In the control group, the patients received a standard treatment only for 7 days, while SEPTIMEB group received SEPTIMEB (6cc vial with 500cc serum glucose infusion 5% daily for one to two hours) plus standard treatment of SEPSIS for 7 days. Then, blood samples were analyzed. APACHE (Acute Physiologic and Chronic Health Evaluation), SOFA (Sequential Organ Failure Assessment), and GCS (Glasgow Coma Score) values were calculated daily.Results: Treatment with SEPTIMEB showed a significant decrease in SOFA value (1.54±0.83) compared to the control group (2.39±0.88) (P<0.001) and a significant increase in GCS value (14.46±0.88) compared to the control group (12.86±1.78) (P<0.001). Improvements of these values can confirm the potential of SEPTIMEB in the reduction of severity of SEPSIS (P<0.05). There were significant decreases in lactate and blood sugar and WBC levels. In addition, inflammatory factors such as ESR (Septimeb group: 52.07±34.80, control group: 51.75±42.10, P=0.98) and CRP (Septimeb group: 48.86±23.21, control group: 49.93±36.22, P=0.92) decreased, but did not show a significant reduction.Conclusion: SEPTIMEB has positive effects on reduction of the severity of SEPSIS which leads to reduction of patients’ mortality rates.

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    APA: Copy

    POURDAST, ALIEH, SANAEI, MARYAM, JAFARI, SIROUS, MOHAMMADI, MOSTAFA, KHALILI, HOSSEIN, SHAFIEE, GITA, AHADI, ZEINAB, ROSTAMI, MAHSA, ALIZAD, SABA, HESHMAT, RAMIN, & MOHRAZ, MINOO. (2017). EFFECT OF SEPTIMEBTM AS A NEW NATURAL EXTRACT ON SEVERE SEPSIS: A RANDOMIZED CLINICAL TRIAL. CASPIAN JOURNAL OF INTERNAL MEDICINE, 8(1), 35-43. SID. https://sid.ir/paper/323401/en

    Vancouver: Copy

    POURDAST ALIEH, SANAEI MARYAM, JAFARI SIROUS, MOHAMMADI MOSTAFA, KHALILI HOSSEIN, SHAFIEE GITA, AHADI ZEINAB, ROSTAMI MAHSA, ALIZAD SABA, HESHMAT RAMIN, MOHRAZ MINOO. EFFECT OF SEPTIMEBTM AS A NEW NATURAL EXTRACT ON SEVERE SEPSIS: A RANDOMIZED CLINICAL TRIAL. CASPIAN JOURNAL OF INTERNAL MEDICINE[Internet]. 2017;8(1):35-43. Available from: https://sid.ir/paper/323401/en

    IEEE: Copy

    ALIEH POURDAST, MARYAM SANAEI, SIROUS JAFARI, MOSTAFA MOHAMMADI, HOSSEIN KHALILI, GITA SHAFIEE, ZEINAB AHADI, MAHSA ROSTAMI, SABA ALIZAD, RAMIN HESHMAT, and MINOO MOHRAZ, “EFFECT OF SEPTIMEBTM AS A NEW NATURAL EXTRACT ON SEVERE SEPSIS: A RANDOMIZED CLINICAL TRIAL,” CASPIAN JOURNAL OF INTERNAL MEDICINE, vol. 8, no. 1, pp. 35–43, 2017, [Online]. Available: https://sid.ir/paper/323401/en

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