EVALUATION OF ANTIOXIDANT, ANTI-INFLAMMATORY AND LIPOXYGENASE INHIBITORY ACTIVITIES OF THE PRENYLATED COUMARIN UMBELLIPRENIN

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IRANSHAHI MEHRDAD; ASKARI M.; SAHEBKAR A.; HADJIPAVLOU LITINA D.

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Journal: DARU Journal of Pharmaceutical Sciences Year:2009 | Volume:17 | Issue:2 Page(s): 99-103

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Title

EVALUATION OF ANTIOXIDANT, ANTI-INFLAMMATORY AND LIPOXYGENASE INHIBITORY ACTIVITIES OF THE PRENYLATED COUMARIN UMBELLIPRENIN

Author(s)

IRANSHAHI MEHRDAD | ASKARI M. | SAHEBKAR A. | HADJIPAVLOU LITINA D. | Issue Writer Certificate

Keywords

UMBELLIPRENIN

ANTIOXIDANT

5-LIPOXYGENASE

ANTI-INFLAMMATORY ACTIVITY

CANCER CHEMOPREVENTION

Abstract

Background and objective: UMBELLIPRENIN, the natural prenylated coumarin distributed in the plants of apiaceae family, has shown various biological activities, especially as a cancer chemo preventive agent. In the present study, UMBELLIPRENIN, was examined for in vitro ANTIOXIDANT activity, in vitro inhibitory activity against lipoxygenase, and in vivo ANTI-INFLAMMATORY ACTIVITY.Methods: The applied tests were interaction with 1,1-diphenyl-2-picryl-hydrazyl (DPPH) stable free radical, inhibition of lipid per oxidation, inhibition of soybean lipoxygenase and in vivo inhibition of the carrageenin-induced rat paw edema.Results: UMBELLIPRENIN did not show any significant ANTIOXIDANT activity but exhibited a remarkable and potent inhibition against soybean lipoxygenase (IC50=0.0725 mM). This compound, in the in vivo anti-inflammatory test, could also inhibit the carrageenin induced paw edema significantly (39%).Conclusion: The observed inhibition of lipoxygenase may be a plausible mechanism for the potent cancer chemo preventive activity of UMBELLIPRENIN and may pose this compound as a valuable agent for the treatment of inflammatory diseases.

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APA: Copy

IRANSHAHI, MEHRDAD, ASKARI, M., SAHEBKAR, A., & HADJIPAVLOU LITINA, D.. (2009). EVALUATION OF ANTIOXIDANT, ANTI-INFLAMMATORY AND LIPOXYGENASE INHIBITORY ACTIVITIES OF THE PRENYLATED COUMARIN UMBELLIPRENIN. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 17(2), 99-103. SID. https://sid.ir/paper/275495/en

Vancouver: Copy

IRANSHAHI MEHRDAD, ASKARI M., SAHEBKAR A., HADJIPAVLOU LITINA D.. EVALUATION OF ANTIOXIDANT, ANTI-INFLAMMATORY AND LIPOXYGENASE INHIBITORY ACTIVITIES OF THE PRENYLATED COUMARIN UMBELLIPRENIN. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2009;17(2):99-103. Available from: https://sid.ir/paper/275495/en

IEEE: Copy

MEHRDAD IRANSHAHI, M. ASKARI, A. SAHEBKAR, and D. HADJIPAVLOU LITINA, “EVALUATION OF ANTIOXIDANT, ANTI-INFLAMMATORY AND LIPOXYGENASE INHIBITORY ACTIVITIES OF THE PRENYLATED COUMARIN UMBELLIPRENIN,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 17, no. 2, pp. 99–103, 2009, [Online]. Available: https://sid.ir/paper/275495/en

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