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Information Journal Paper

Title

Preparation, process optimization and characterization of core-shell polyurethane/chitosan nanofibers as a potential platform for bioactive scaffolds

Pages

  273-282

Abstract

 In this paper, Polyurethane (PU), Chitosan (Cs)/polyethylene oxide (PEO), and core-shell PU/Cs Nanofibers were produced at the optimal processing conditions using electrospinning technique. Several methods including SEM, TEM, FTIR, XRD, DSC, TGA and image analysis were utilized to characterize these nanofibrous structures. SEM images exhibited that the core-shell PU/Cs Nanofibers were spun without any structural imperfections at the optimized processing conditions. TEM image confirmed the PU/Cs core-shell Nanofibers were formed apparently. It that seems the inclusion of Cs/PEO to the shell, did not induce the significant variations in the crystallinity in the core-shell Nanofibers. DSC analysis showed that the inclusion of Cs/PEO led to the glass temperature of the composition increased significantly compared to those of neat PU Nanofibers. The thermal degradation of core-shell PU/Cs was similar to PU Nanofibers degradation due to the higher PU concentration compared to other components. It was hypothesized that the core-shell PU/Cs Nanofibers can be used as a potential platform for the bioactive scaffolds in tissue engineering. Further biological tests should be conducted to evaluate this platform as a three dimensional scaffold with the capabilities of releasing the bioactive molecules in a sustained manner.

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    APA: Copy

    Maleknia, Laleh, Dilamian, Mandana, Kazemi Pilehrood, Mohammad, SADEGHI ALIABADI, HOJJAT, & Hekmati, Amir Houshang. (2018). Preparation, process optimization and characterization of core-shell polyurethane/chitosan nanofibers as a potential platform for bioactive scaffolds. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), 13(3), 273-282. SID. https://sid.ir/paper/756116/en

    Vancouver: Copy

    Maleknia Laleh, Dilamian Mandana, Kazemi Pilehrood Mohammad, SADEGHI ALIABADI HOJJAT, Hekmati Amir Houshang. Preparation, process optimization and characterization of core-shell polyurethane/chitosan nanofibers as a potential platform for bioactive scaffolds. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS)[Internet]. 2018;13(3):273-282. Available from: https://sid.ir/paper/756116/en

    IEEE: Copy

    Laleh Maleknia, Mandana Dilamian, Mohammad Kazemi Pilehrood, HOJJAT SADEGHI ALIABADI, and Amir Houshang Hekmati, “Preparation, process optimization and characterization of core-shell polyurethane/chitosan nanofibers as a potential platform for bioactive scaffolds,” RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), vol. 13, no. 3, pp. 273–282, 2018, [Online]. Available: https://sid.ir/paper/756116/en

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