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Information Journal Paper

Title

PREVALENCE OF NONALCOHOLIC STEATOHEPATITIS IN IRAN: A POPULATION BASED STUDY

Pages

  14-19

Abstract

 Background: Non-alcoholic FATTY LIVER disease/steatohepatitis (NAFLD/NASH) is the most common form of chronic liver disease world wide and is no longer considered a benign disease. Its PREVALENCE has not been determined in a large-scale population-based study in IRAN.Methods: A total of 6583 individuals aged 18 to 65 were randomly selected from three geographically distinct provinces in IRAN. Blood samples were obtained from each subject and a questionnaire was completed exploring data including self-admitted regular alcohol use. Serums were tested for anti-HCV antibody (anti-HCV), hepatitis B surface antigen and anti-hepatitis B core antibody. Positive samples for anti-HCV antibody were re-tested and those positive in a repeat ELISA were confirmed by a recombinant immunoblot assay (RIBA) test. Serums were also tested for ALT levels. Subjects with elevated ALT defined as serum ALT ³40 IU/L with no history of alcohol consumption and negative HBV and HCV infection were considered as “presumed NASH”.Resultsts: In this study 5589 subjects were analyzed. Two hundred and forty two individuals (4.3%) were diagnosed with elevated ALT levels. Among individuals with elevated ALT, 15 (6.2%) were diagnosed with either hepatitis B or hepatitis C. The overall weighted PREVALENCE of presumed NASH was 2.9%. According to multivariate analysis, male sex, urban lifestyle, and being overweight or obese were significantly associated with “presumed NASH”.Conclusion: Obesity and metabolic syndrome, the most predictive factors of FATTY LIVER disease, are increasing in IRAN, therefore the PREVALENCE of NAFLD/NASH and related complications are expected to increase in the future. This population based study gives a crude estimate of the PREVALENCE of NASH around the country. Studies with more accurate surrogates of NASH need to be done. The disparity among different provinces merits special consideration.

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    APA: Copy

    SOHRABPOUR, A.A., REZVAN, H., AMINI KAFIABAD, S., DEYHIM, M.R., MERAT, S., & POURSHAMS, A.. (2010). PREVALENCE OF NONALCOHOLIC STEATOHEPATITIS IN IRAN: A POPULATION BASED STUDY. MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD), 2(1), 14-19. SID. https://sid.ir/paper/319008/en

    Vancouver: Copy

    SOHRABPOUR A.A., REZVAN H., AMINI KAFIABAD S., DEYHIM M.R., MERAT S., POURSHAMS A.. PREVALENCE OF NONALCOHOLIC STEATOHEPATITIS IN IRAN: A POPULATION BASED STUDY. MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD)[Internet]. 2010;2(1):14-19. Available from: https://sid.ir/paper/319008/en

    IEEE: Copy

    A.A. SOHRABPOUR, H. REZVAN, S. AMINI KAFIABAD, M.R. DEYHIM, S. MERAT, and A. POURSHAMS, “PREVALENCE OF NONALCOHOLIC STEATOHEPATITIS IN IRAN: A POPULATION BASED STUDY,” MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD), vol. 2, no. 1, pp. 14–19, 2010, [Online]. Available: https://sid.ir/paper/319008/en

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