EFFECT OF VITAMIN E ON FASTING AND POSTPRANDIAL OXIDATIVE STRESS, INFLAMMATORY MARKERS, GLUCOSE STATUS AND INSULIN RESISTANCE IN TYPE 2 DIABETIC PATIENTS: A RANDOMIZED CLINICAL TRIAL

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HEJAZI N.; MAZLOOM Z.; DABBAGHMANESH M.H.

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Paper Information

Journal: NUTRITION AND FOOD SCIENCES RESEARCH Year:2014 | Volume:1 | Issue:SUPPL. (1) Page(s): 140-140

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Title

EFFECT OF VITAMIN E ON FASTING AND POSTPRANDIAL OXIDATIVE STRESS, INFLAMMATORY MARKERS, GLUCOSE STATUS AND INSULIN RESISTANCE IN TYPE 2 DIABETIC PATIENTS: A RANDOMIZED CLINICAL TRIAL

Author(s)

HEJAZI N. | MAZLOOM Z. | DABBAGHMANESH M.H. | Issue Writer Certificate

Keywords

VITAMIN E

DIABETES

POSTPRANDIAL PERIOD

OXIDATIVE STRESS

INFLAMMATION

ATHEROSCLEROSIS

CLINICAL-TRIAL

Abstract

Background: ATHEROSCLEROSIS is one of the prevalent complications in diabetic patients. Increased free radicals in DIABETES activate stress sensitive signaling pathway, resulting in this outcome. This study examines the effect of short term supplementation of VITAMIN E on different biochemical markers in type 2 diabetic patients, in this regard to prevent from ATHEROSCLEROSIS in this group.Methods: In this single-blind placebo controlled trial, 30 type 2 diabetic patients were randomly divided into two groups of study to receive VITAMIN E (400IU) or identical placebo capsules daily for 6 weeks. Serum level of lipoproteins, glucose, insulin, malondialdehyde (MDA), interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), pulse rate and blood pressure were measured in fasting and postprandial (after a fatty meal) states before and after six weeks of supplementation.Results: There wasn’t any significant difference in fasting and postprandial lipid profile (Triglyceride, HDL-, LDL- and total Cholesterol), glucose, insulin and HOMA-IR after six weeks of intervention between the two groups. However, the result of our study showed a significant decrease in fasting and postprandial MDA levels and postprandial pulse rate and a significant increase in fasting IL-6 in VITAMIN E group compared to the controls after supplementation.There were no significant differences between the groups in other markers.Conclusion: This study suggests that short term supplementation of VITAMIN E can reduce OXIDATIVE STRESS in fasting and postprandial states in type 2 diabetic patients and may prevent diabetic complications; in addition increment of IL-6 after supplementation may play a role in attenuating Type 2 DIABETES by anti-inflammatory effect.

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APA: Copy

HEJAZI, N., MAZLOOM, Z., & DABBAGHMANESH, M.H.. (2014). EFFECT OF VITAMIN E ON FASTING AND POSTPRANDIAL OXIDATIVE STRESS, INFLAMMATORY MARKERS, GLUCOSE STATUS AND INSULIN RESISTANCE IN TYPE 2 DIABETIC PATIENTS: A RANDOMIZED CLINICAL TRIAL. NUTRITION AND FOOD SCIENCES RESEARCH, 1(SUPPL. (1)), 140-140. SID. https://sid.ir/paper/342378/en

Vancouver: Copy

HEJAZI N., MAZLOOM Z., DABBAGHMANESH M.H.. EFFECT OF VITAMIN E ON FASTING AND POSTPRANDIAL OXIDATIVE STRESS, INFLAMMATORY MARKERS, GLUCOSE STATUS AND INSULIN RESISTANCE IN TYPE 2 DIABETIC PATIENTS: A RANDOMIZED CLINICAL TRIAL. NUTRITION AND FOOD SCIENCES RESEARCH[Internet]. 2014;1(SUPPL. (1)):140-140. Available from: https://sid.ir/paper/342378/en

IEEE: Copy

N. HEJAZI, Z. MAZLOOM, and M.H. DABBAGHMANESH, “EFFECT OF VITAMIN E ON FASTING AND POSTPRANDIAL OXIDATIVE STRESS, INFLAMMATORY MARKERS, GLUCOSE STATUS AND INSULIN RESISTANCE IN TYPE 2 DIABETIC PATIENTS: A RANDOMIZED CLINICAL TRIAL,” NUTRITION AND FOOD SCIENCES RESEARCH, vol. 1, no. SUPPL. (1), pp. 140–140, 2014, [Online]. Available: https://sid.ir/paper/342378/en

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