مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

CORRELATION BETWEEN C677T AND A1298C MUTATIONS ON THE MTHFR GENE WITH PLASMA HOMOCYSTEINE LEVELS AND VENOUS THROMBOSIS IN PREGNANT WOMEN AT RISK OF THROMBOSIS

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Abstract

 Background: DEEP VENOUS THROMBOSIS (DVT) is a common disease with a high morbidity, mortality and increase in miscarriages.Objectives: The purpose of this study was to assessment the correlation between C677T and A1298C MUTATIONS on the methylenetetrahydrofolate reductase (MTHFR) gene with total plasma HOMOCYSTEINE levels and DEEP VENOUS THROMBOSIS in PREGNANT WOMEN at risk of thrombosis.Patients and Methods: In this case-control study, 120 PREGNANT WOMEN with risk of DVT and 100 PREGNANT WOMEN without risk of DVT were included in the study. Assay for identification of MTHFR MUTATIONS was carried out by PCR-RFLP. Total plasma HOMOCYSTEINE was measured by ELISA method.Results: Homozygous (MM) MUTATIONS of MTHFR C677T and A1298C were not associated with DVT in PREGNANT WOMEN with and without DVT, respectively. Plasma HOMOCYSTEINE levels were significantly higher in PREGNANT WOMEN with DVT (18.3±5.9 mmol/L) than in the PREGNANT WOMEN without DVT (8.9±6.4 mmol/L) in C677T and A1298C MUTATIONS on the MTHFR gene, respectively (P=0.021).Conclusions: Our results showed that MTHFR C677T and MTHFR A1289C polymorphisms are not connected with total plasma HOMOCYSTEINE levels in PREGNANT WOMEN with and without DVT. Also, plasma HOMOCYSTEINE levels were significantly higher in PREGNANT WOMEN with DVT.

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    APA: Copy

    GHAFFARI, KAZEM, GHASEMI, ALI, GHOTASLOU, ABBAS, MOHAMMADI, MOHSEN, & SALMANPOUR, ZEYNAL. (2015). CORRELATION BETWEEN C677T AND A1298C MUTATIONS ON THE MTHFR GENE WITH PLASMA HOMOCYSTEINE LEVELS AND VENOUS THROMBOSIS IN PREGNANT WOMEN AT RISK OF THROMBOSIS. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 17(12), 0-0. SID. https://sid.ir/paper/685213/en

    Vancouver: Copy

    GHAFFARI KAZEM, GHASEMI ALI, GHOTASLOU ABBAS, MOHAMMADI MOHSEN, SALMANPOUR ZEYNAL. CORRELATION BETWEEN C677T AND A1298C MUTATIONS ON THE MTHFR GENE WITH PLASMA HOMOCYSTEINE LEVELS AND VENOUS THROMBOSIS IN PREGNANT WOMEN AT RISK OF THROMBOSIS. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2015;17(12):0-0. Available from: https://sid.ir/paper/685213/en

    IEEE: Copy

    KAZEM GHAFFARI, ALI GHASEMI, ABBAS GHOTASLOU, MOHSEN MOHAMMADI, and ZEYNAL SALMANPOUR, “CORRELATION BETWEEN C677T AND A1298C MUTATIONS ON THE MTHFR GENE WITH PLASMA HOMOCYSTEINE LEVELS AND VENOUS THROMBOSIS IN PREGNANT WOMEN AT RISK OF THROMBOSIS,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 17, no. 12, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/685213/en

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