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مرکز اطلاعات علمی SID1
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
Title: 
Author(s): 

Issue Info: 
  • Year: 

    0
  • Volume: 

    27
  • Issue: 

    4
  • Pages: 

    -
Measures: 
  • Citations: 

    0
  • Views: 

    654
  • Downloads: 

    0
Keywords: 
Abstract: 

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Title: 
Author(s): 

Issue Info: 
  • Year: 

    0
  • Volume: 

    27
  • Issue: 

    4
  • Pages: 

    -
Measures: 
  • Citations: 

    0
  • Views: 

    562
  • Downloads: 

    0
Keywords: 
Abstract: 

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View 562

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Issue Info: 
  • Year: 

    2018
  • Volume: 

    27
  • Issue: 

    4
  • Pages: 

    223-236
Measures: 
  • Citations: 

    2
  • Views: 

    1800
  • Downloads: 

    1271
Abstract: 

Targeted genome editing by RNA-guided nucleases is a high throughput and facile approach which not only provides modifications, gene editing and functional studies for researchers, but also develops their knowledge about molecular basis of diseases and stablishes novel targeted therapies. Several platforms for molecular scissors that enable targeted genome engineering have been developed, including zinc-finger nucleases (ZFNs), transcription activation-like effector nucleases (TALENs) and clustered regularly interspaced palindromic repeats (CRISPR)/CRISPR-associated-9 (Cas9). Indeed CRISPR/Cas9 system is bacterial defensive system against viral invasions. Cas9 protein can be targeted to DNA sequences by accompanying single-strand RNA guide which base-pairs directly with target DNA to introduce modifications. Improvements are urgently needed for various aspects of system, including delivery and control over the outcome of the repair process. CRISPR/Cas9 holds enormous therapeutic potential for the treatment of genetic disorders by directly correcting disease causing mutations. Although the Cas9 protein has been shown to bind and cleave DNA at off-target sites the field of Cas9 specificity is rapidly progressing with marked improvements in guide RNA selection, novel enzymes and off-target detection methods. In this review we discuss history and different aspects of CRISPR/Cas9 including advances in specificity strategies for genome engineering, system delivery and control optimization on repair processes along with its implication for the future of biological researches and gene therapy.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Issue Info: 
  • Year: 

    2018
  • Volume: 

    27
  • Issue: 

    4
  • Pages: 

    237-243
Measures: 
  • Citations: 

    0
  • Views: 

    1538
  • Downloads: 

    937
Abstract: 

Health industry is one of the important and growing sections of the global economy. Every year, billions of dollars are spent to improve information systems and provide better care services and greater efficiency in the health sector organizations. Information Systems Strategic Planning (ISSP) in health sector organizations is a tool for informed decision-making to achieve the macro and micro objectives of organizations in the Health Sector and prevent the waste and failure of huge investments in information technology of the organization. This is a non-systematic review study and research data includes required papers and books collected through library and Internet. Several databases such as ProQuest, Web of Science, Scopus, Ovid, Cochrane Library Medline, ISC, Irandoc, Sid, Magiran, Iranmedex Medlib and google Scholar search engine were investigated with keywords including electronic health strategy, medical informatics, electronic health record (EHR), telemedicine and electronic prescribing, E-health strategic planning. This study demonstrated that despite many efforts to implement Electronic Health in Iran, electronic health strategy is in generalities and not fully operational, due to lack of stability and the administrative obstacles. On the other hand, the short comings in the country's IT infrastructures, attitudinal and behavioral constraints, financial constraints, rapid changes of managers and the lack of skilled manpower are of the main obstacles affecting the development of Electronic Health Strategy in Iran. To eliminate these barriers, we need to have a national strategic plan, coordination, the existence of required regulations and standards, related software applications, electronic security systems and promotion of the use of information technology in the health system of the country.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View 1538

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Issue Info: 
  • Year: 

    2018
  • Volume: 

    27
  • Issue: 

    4
  • Pages: 

    244-251
Measures: 
  • Citations: 

    0
  • Views: 

    700
  • Downloads: 

    225
Abstract: 

Background: Cholestasis occurs when the secretion of bile flow into the small intestine is impaired. Without appropriate treatment, cholestasis could induce harmful injuries to different organs. Moreover, this disorder could alter the expression level of apoptotic-related genes. Herein, the effect of cholestasis on the expression level of both anti-and pro-apoptotic genes, Bcl-xl and Bad, in the striatum area of rats were investigated. In addition, we aimed to examine whether curcumin could change the mRNA expression level of aforementioned genes in striatum area of rats. Materials and methods: In this experimental study, sixteen male Wistar rats were divided into 4 groups, consisting control, sham-curcumin, BDL and BDL-curcumin groups. Rats in BDL group experienced bile duct obstruction surgery; however, in BDL-curcumin group, rats underwent surgery plus curcumin treatment. Sham-curcumin group were only treated with drug. The control group did not have either surgery or drug treatment. The striatum area of the brain was isolated and after RNA extraction and cDNA synthesis, the expression level of genes were investigated. Results: The ratio of pro-apoptotic to anti-apoptotic genes (Bad/Bcl-xl) in the BDL group significantly changed, compared to other groups (p<0. 05). But, in both BDL-curcumin and sham-curcumin groups, the expression level of neither pro-nor anti-apoptotic genes altered in the striatum area of the brain. Conclusion: Curcumin decreased the relative expression level of death promoter to death repressor genes and reduced the BDL-induced apoptosis. Hence, curcumin can be used to reduce the harmful effect of cholestasis.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Issue Info: 
  • Year: 

    2018
  • Volume: 

    27
  • Issue: 

    4
  • Pages: 

    252-260
Measures: 
  • Citations: 

    0
  • Views: 

    567
  • Downloads: 

    109
Abstract: 

Background: Cholestasis, as an abnormality in liver function, is associated with decreasing water intake and changes in vasopressin level. The Paraventricular (PVN) and Supraoptic (SON) nuclei are important for the control of body fluid homeostasis. This can be take place with water channels or aquaporins to regulate water flow. Aquaporin 4 isoforms effectively convey the water on the brain. Due to reduced water intake in cholestasis and the roles of SON and PVN nuclei, this study was designed to determine the changes in aquaporin 4. Materials and methods: In this experimental study, male Wistar rats weighing 200 to 250 g were randomly divided into three groups, including the control (no surgery), sham (surgery Stretch) and cholestatic that had closed their bile duct (model used to cirrhosis), respectively. Aquaporin 4 densities in all groups were examined by immunohistochemistry. Results: The results indicate a high density of aquaporins 4 in SON and PVN nuclei in sham and control samples, but the sampling density of aquaporin 4 decreased in cholestasis. Conclusion: The results of this study showed decreasing density of aquaporin 4 in SON and PVN of hypothalamus, in the parts of the effective in water intake and sensitive to the osmolarity and toxicity, in cholestasis. Cholestasis may probably reduce the density of aquaporin 4 and the water intake by increasing or decreasing of related factors, such as endotoxins.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Author(s): 

SHABANI RAMIN

Issue Info: 
  • Year: 

    2018
  • Volume: 

    27
  • Issue: 

    4
  • Pages: 

    261-268
Measures: 
  • Citations: 

    0
  • Views: 

    657
  • Downloads: 

    565
Abstract: 

Background: Research suggests that the decline in ovarian function with menopause is associated with spontaneous increases in pro inflammatory and coagulation factors. The aim of this study was to determine the effect of combined training on body composition, and inflammatory and coagulation factors in overweight and obese postmenopausal women. Materials and methods: In this quasi experimental study, a total of twenty-six apparently health postmenopausal women were randomly assigned to an endurance resistance exercise (n = 13) or control group (n = 13). The exercise group trained 90 minute, three times per week for 8 weeks. The control group did not train. End points included changes in weight, body mass index (BMI), waist-to-hip ratio (WHR), and serum high sensitive C-reactive protein (hs-CRP), interleukin 6 (IL-6), and plasma fibrinogen between baseline and 8-th week. Data were analyzed by paired and independent t test. P-value<0. 05 was considered significant. Results: Twenty-two participants completed the trial. At baseline, there were no significant differences in study variables between control and exercise groups. Exercise training significantly reduced weight, BMI, and WHR (p=0. 001). Also exercise training decreased plasma levels of hs-CRP and IL-6 (p=0. 001), and fibrinogen (p=0. 01) in experimental group. While the control group showed no significant changes during this period. Conclusion: Our study showed that exercise training is effective in reducing body composition and inflammatory and coagulation factors in overweight and obese postmenopausal women. So, Our results suggest that an endurance-resistance exercise program can improve health status of postmenopausal women.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Issue Info: 
  • Year: 

    2018
  • Volume: 

    27
  • Issue: 

    4
  • Pages: 

    269-276
Measures: 
  • Citations: 

    0
  • Views: 

    812
  • Downloads: 

    694
Abstract: 

Background: Group acceptance and commitment therapy, as a treatment method, has direct and two-way correlation with reducing health anxiety. The aim of the present study was to evaluate the efficacy of group acceptance and commitment therapy on health anxiety of woman with epilepsy with three-month follow-up. Materials and methods: The present study was a controlled experimental study with pre-test and post-test design. Among the female patients with epilepsy admitted to the health centers of Kermanshah, 30 persons were selected through purposeful sampling and randomly assigned to experimental and control groups (15 in experimental and 15 in control groups). Both groups responded to health anxiety scale, at the pre-test stage. In the experimental group, the group acceptance and commitment therapy intervention were conducted for 8 sessions of 90-minute. After completing the session, post-test and three months after the intervention, follow-up was conducted on two experimental and control groups. Data analysis was done using spss19 by descriptive tests and ANOVA with repeated measure. Results: ANOVA with repeated measure analysis showed that the group acceptance and commitment therapy had a significant positive effect on decreasing health anxiety. Findings were also preserved in the follow-up phase. Conclusion: The results of research showed that of group acceptance and commitment therapy intervention can be used as an efficient way to decrease health anxiety in patients with epilepsy.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Issue Info: 
  • Year: 

    2018
  • Volume: 

    27
  • Issue: 

    4
  • Pages: 

    277-281
Measures: 
  • Citations: 

    0
  • Views: 

    1179
  • Downloads: 

    558
Abstract: 

Background: : Fatty liver disease is one of the dangerous outcomes of progressive hepatitis B or C infections and in the recent years had been known as one of the causes of cirrhosis and hepatic failure. Present study was performed to assess fatty liver prevalence among patients with viral hepatitis. Materials and methods: This case-control study was performed to compare ultrasonography findings of patients who referred to Royan infertility clinic and Amiralmomenin Hospital with positive hepatitis B or C infection and also control subjects. Ultrasonography was performed for all of study participants and hepatic tissue changes, ascites, splenomegaly and hepatomegaly were evaluated. Results: There was no significant difference between frequency of fatty liver disorder among patients with and without hepatitis B or C infection. Frequency of fatty liver disorders had not significant association with age and gender of study participants. Frequency of hepatomegaly was significantly higher among patients with hepatitis C infection compared with control subjects. Conclusion: Present study suggests that control of sonographic findings of fatty liver changes and other related factors were necessary for patients with chronic hepatitis infection.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View 1179

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Issue Info: 
  • Year: 

    2018
  • Volume: 

    27
  • Issue: 

    4
  • Pages: 

    282-289
Measures: 
  • Citations: 

    0
  • Views: 

    661
  • Downloads: 

    252
Abstract: 

Background: The evolution of information technology has affected all sectors of society including education. The precondition for the use of E-learning is the existence of contexts and clear view about it. The aim of this study was to determine the possibility of holding virtual training course at the School of Nursing and Midwifery, Islamic Azad University, from the perspective of faculty member. Materials and methods: This descriptive-survey study was done on 51 faculty members of Nursing and Midwifery faculty. Data were collected through questionnaires including 54 questions with 5-point Likert scale and in the 7 domains of technological, human, leadership and management, administrative and support, cultural and social, economic and pedagogical. Validity and reliability were evaluated and confirmed (Cronbach's alpha coefficient 87%). Answers were analyzed by descriptive and inferential statistics (One-sample T test and Eta correlation) using SPSS (ver19) software. Results: The average of responses for all domains was higher than the average (P<0. 0001). The correlation coefficient ETA did not show strong correlation between demographic variables, including gender and education level of the participants, with total score of the questionnaire; but by increasing age of the participants, the total score of the questionnaire increased with effectiveness of 42 percent. Conclusion: According to the results, Faculty of Nursing and Midwifery have acceptable readiness for virtual training courses and must act to hold the course.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Author(s): 

KHAKIZADEH SIMA | ADHAMI MOGHADAM FARHAD | SHOSHTARIAN SEYED MOHAMMAD MASOUD

Issue Info: 
  • Year: 

    2018
  • Volume: 

    27
  • Issue: 

    4
  • Pages: 

    290-293
Measures: 
  • Citations: 

    0
  • Views: 

    1424
  • Downloads: 

    194
Abstract: 

Background: This study was performed to evaluate the rate of abnormality in the ERG test (electroretinogram test) in the cyclosporine users referred to the Basir Clinic during 2015-2016. Materials and methods: In this case-control study, 50 patients who had been prescribed cyclosporine referred to the Basir Clinic during 2015-2016 were studied. Results of ERG test, including voltage and the delayed phase, were determined and were compared to the findings of the control group. Results: The mean (± standard deviation) of the recorded voltages in the ERG in the experimental group and control group were 117. 1± 14. 9 microvolt and 116. 2± 14. 3 microvolt, respectively (P=0. 82). The mean (± standard deviation) of recorded delayed phase in the ERG in the experimental group was 44. 33± 2. 24 microsecond, compared to 43. 42± 2. 11 microsecond in the control group (P=0. 14). Conclusion: According to the acquired results of this study, generally it is inferred that using cyclosporine do not significantly change the result of electroretinogram (ERG).

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View 1424

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Issue Info: 
  • Year: 

    2018
  • Volume: 

    27
  • Issue: 

    4
  • Pages: 

    294-300
Measures: 
  • Citations: 

    0
  • Views: 

    1236
  • Downloads: 

    936
Abstract: 

Background: Cervical cancer is one of the most common cancers in women. Human papillomavirus (HPV) is known as one of the predominant causes of cervical cancer. Current paper aimed to evaluate level of awareness about these problems. Materials and methods: In this cross-sectional descriptive study, 426 women referred to Gynecology Clinic of Tonekabon Shahid Rajaei Hospital, Mazandaran in 2016 were studied. The Sampling method was convenient. Data collection instrument was a questionnaire which was made by the researcher. Statistical software SPSS. 22 and Chi-square were used to analyze collected data. Results: 141 patients (34%) had done the Pap smear test. 186 patients (44%) had good knowledge about cervical cancer and only 129 (30%) had poor knowledge about cancer. Subjects had low mean of awareness about the HPV. There was no significant relationship between age and place of residence and awareness of the HPV. However, there was a significant relationship between the level of education, occupation, marital status and awareness of this virus (P<0. 05). Conclusion: In this study, it was found that the level of women's awareness of cervical cancer and Pap smear test are in the relatively good condition. Also, almost 40% of women had done Pap smear tests. But, women's awareness about the HPV was very limited and incomplete. Therefore, informing and proper training seems necessary.

Yearly Impact: مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View 1236

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