THE EFFECT OF HEPATIC IMPAIRMENT ON THE AQUAPORIN-4 IN THE PARAVENTRICULAR (PVN) AND SUPRAOPTIC (SON) NUCLEI OF RAT HYPOTHALAMUS

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ESLIMI ESFAHANI DELARAM; ORYAN SHAHRBANOO; NABIUNI MOHAMMAD; KARIMIAN PEIRO MANIJEH; GHAROONI FATEMEH

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Journal: MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY Year:2018 | Volume:27 | Issue:4 Page(s): 252-260

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Title

THE EFFECT OF HEPATIC IMPAIRMENT ON THE AQUAPORIN-4 IN THE PARAVENTRICULAR (PVN) AND SUPRAOPTIC (SON) NUCLEI OF RAT HYPOTHALAMUS

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Keywords

HEPATIC IMPAIRMENTQ1

AQUAPORIN 4Q1

PARAVENTRICULAR NUCLEUS (PVN)Q1

SUPRAOPTIC NUCLEUS (SON)Q1

Abstract

Background: Cholestasis, as an abnormality in liver function, is associated with decreasing water intake and changes in vasopressin level. The Paraventricular (PVN) and Supraoptic (SON) nuclei are important for the control of body fluid homeostasis. This can be take place with water channels or aquaporins to regulate water flow. AQUAPORIN 4 isoforms effectively convey the water on the brain. Due to reduced water intake in cholestasis and the roles of SON and PVN nuclei, this study was designed to determine the changes in AQUAPORIN 4. Materials and methods: In this experimental study, male Wistar rats weighing 200 to 250 g were randomly divided into three groups, including the control (no surgery), sham (surgery Stretch) and cholestatic that had closed their bile duct (model used to cirrhosis), respectively. AQUAPORIN 4 densities in all groups were examined by immunohistochemistry. Results: The results indicate a high density of aquaporins 4 in SON and PVN nuclei in sham and control samples, but the sampling density of AQUAPORIN 4 decreased in cholestasis. Conclusion: The results of this study showed decreasing density of AQUAPORIN 4 in SON and PVN of hypothalamus, in the parts of the effective in water intake and sensitive to the osmolarity and toxicity, in cholestasis. Cholestasis may probably reduce the density of AQUAPORIN 4 and the water intake by increasing or decreasing of related factors, such as endotoxins.

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APA: Copy

ESLIMI ESFAHANI, DELARAM, ORYAN, SHAHRBANOO, NABIUNI, MOHAMMAD, KARIMIAN PEIRO, MANIJEH, & GHAROONI, FATEMEH. (2018). THE EFFECT OF HEPATIC IMPAIRMENT ON THE AQUAPORIN-4 IN THE PARAVENTRICULAR (PVN) AND SUPRAOPTIC (SON) NUCLEI OF RAT HYPOTHALAMUS. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 27(4 ), 252-260. SID. https://sid.ir/paper/98893/en

Vancouver: Copy

ESLIMI ESFAHANI DELARAM, ORYAN SHAHRBANOO, NABIUNI MOHAMMAD, KARIMIAN PEIRO MANIJEH, GHAROONI FATEMEH. THE EFFECT OF HEPATIC IMPAIRMENT ON THE AQUAPORIN-4 IN THE PARAVENTRICULAR (PVN) AND SUPRAOPTIC (SON) NUCLEI OF RAT HYPOTHALAMUS. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2018;27(4 ):252-260. Available from: https://sid.ir/paper/98893/en

IEEE: Copy

DELARAM ESLIMI ESFAHANI, SHAHRBANOO ORYAN, MOHAMMAD NABIUNI, MANIJEH KARIMIAN PEIRO, and FATEMEH GHAROONI, “THE EFFECT OF HEPATIC IMPAIRMENT ON THE AQUAPORIN-4 IN THE PARAVENTRICULAR (PVN) AND SUPRAOPTIC (SON) NUCLEI OF RAT HYPOTHALAMUS,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 27, no. 4 , pp. 252–260, 2018, [Online]. Available: https://sid.ir/paper/98893/en

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