Razi Journal of Medical Sciences
Year:2012 | Volume:19 | Issue:95|Papers Count:7

Background: The aim of this research is investigation of Cu/Zn Superoxide Dismutase enzyme of lymphocytic cell gene expression, total antioxidant status and oxidative stress changes following intensive exercise in young men athletes.Methods: This study was a semi-experimental research with a repeated measures design. 20 young men athletes (age range of 21-23 years) participated in this study after signing an informed consent form. Blood sample were collected in pre intensive exercise (grade: 5%, speed: 7.5 mile/h, time: 20 minutes) immediately and recovery (3 hours after exercise test), and Real time-polymerase chain reaction was used for evaluation of Cu/Zn SOD gene expression and autoanalyzer for other markers.Results: H2O2 level and mRNA of Cu/Zn SOD were both increased, immediately and 3 hours after of exercise (p=0.012, p=0.014), (2.95±0.84 and 3.37±0.99) but this changes were not reported significant, but TAS levels areeffectively, raised only in recovery state (p=0.009) (0.86±0.16).Conclusions: Intensive exercise increases oxidative stress markers and can weakens the immune system of men athletes, but they raisethe activity of antioxidant enzymes in response to threat of free radicals, so Cu/Zn SOD gene expression does not significantly increased.

Background: TPO gene variations are one of the causes of thyroid autoimmune diseases. The aim of this study was to examine the association between the T1936C, T2229C and A2257C SNPs (single nucleotide polymorphisms) of the TPO gene and Anti-TPO level.Methods: In this case-control study, 188 individuals (86 males and 102 females), aged 20-80 years, were randomly selected from the Tehran Lipid and Glucose Study population (TLGS). A2257C and T2229C SNPs were detected with RFLP by use of BsrI and Eco57I as restrictive enzymes respectively, while the T1936C SNP was determined with ARMS-PCR.Results: In the presence of the C allele of T1936C, Anti-TPO level was significantly increased (CC: 238±43.3, CT: 47.7±15.9, TT: 74.1±11.3 IU/L; p 0.002); however, it disappeared after adjustment for sex and age (p 0.059). No significant difference, before and after adjustment, was found in Anti-TPO level in the presence of T2229C SNP (CC: 129.1±24.5, CT: 43.5±12.6, TT: 126.5±13.8 IU/L; p 0.196). The association of A2257C with Anti-TPO level was only significant after adjustment for sex and age (p 0.007), and between the ATC, CTT haplotypes and Anti-TPO level, the association was significant (p 0.023, 0.021); however, the association it was dominant between CTT and anti-TPO concentration was significant only after adjustment for sex (p 0.014).Conclusion: The result of this study, showed age and sex as potential confounders which could modify the association between TPO polymorphisms and Anti-TPO level in a Tehranian population.

Background: Smoking hookah is recognized as a growing health problem in Iran and many countries in the world and its harmful outcomes on human health have attracted attention of medical community. This study aimed to determine the factors affecting on hookah smoking in male students who are living in dormitories of Tehran University of Medical Sciences in 2011.Methods: This study was a descriptive analytical. The questionnaire was developed and its validity and reliability was assessed. Then, 162 male students living in dormitories at Tehran University of Medical Sciences were selected in multi-stage sampling and questionnaires were filled out by them. The collected data were analyzed by SPSS software and the Chi-Square and Independent sample Ttests.Results: The results showed that 29% of subjects had history of smoking hookah. The main factors affecting the use of hookah from subject’s point of view, were filling leisure time, cost-effectiveness, anxiety reduction, refreshment and easy access to the hookah.Conclusion: Designing multi-dimensional activities for filling leisure time of college students who living in dormitories (such as promote sports activities), teaching of problem-solving methods for reducing anxiety and fatigue and learning skills to say “NO” against request of friends for smoking hookah, can lead to reduced smoking hookah in this group.

Background: The purpose of this study is detecting short-term survival of all hospitalized patients with acute myocardial infarction in Isfahan and Najaf Abad based on sex.Methods: The data of all patients who were hospitalized with acute myocardial infarction between 1378 to 1387 in Isfahan and Najaf Abad were collected by trained nurses of the surveillance department in a research center. Using these information and Cox proportional hazard method, Kaplan-Meier method and log Rank test, the survival by sex in different subgroups of patients, was determined and compared between two sexes.Results: Short-term 28 days survival following the occurrence of acute myocardial infarction is 90.9%. A significant difference was seen between overall women and men survival (Respectively, 86.7% vs. 92.5% p<0.001). It decreases significantly with increasing age and increases with thrombolytic use.Conclusion: The survival rate of acute myocardial infarction in Iranian women is less than men. Physicians should pay more attention to the treatment and care of patients at higher risk of mortality, especially women and older patients.