Background and Aim: Quality of life, because of its significant role in mental health has become very important in recent years. This aim of this study was to compare the quality of life of women with, and without primary dysmenorrhea and their pain reduction strategies in patients referred to Shahid Beheshti University of Medical Sciences affiliated health centers in Tehran.Materials and Methods: This was a descriptive-comparative study. 390 women with, and without primary dysmenorrhea were divided into two groups of 195 participated. The samples were selected randomly from health centers in three regions of North, East and shemiranat of Tehran. Multi-stage cluster sampling method was used and the study units entered based on inclusion criteria and their desire to participate in the study. Data collection tools were demographic and midwifery information questionnaire, strategies used for dysmenorrhea pain scale and health-related quality of life questionnaire (SF-36). Data analysis was carried out by SPSS 22 software. The data was analyzed using independent t-tests, Chi-square, Pearson's and Spearman correlation.Findings: Most of the study participants were married, with college education and the mean age was 24.23. The averages of quality of life score in participants with and without primary dysmenorrhea were 68.97 and 77.93 (of 100 points) respectively. Independent t-test in both groups showed a significant difference (p <0.05) in all aspects of quality of life (general health, bodily pain, physical functioning, physical limitations, emotional limitations, social function, mental health, vitality). The most frequent strategies in pain reduction were use of analgesics (37.8%). Among analgesics, Gelofen (25.8%) and Mefenamic acid (11.5%) had the highest rate.Conclusion: Comparing the quality of life in both groups showed a significant difference in all aspects. The most measures used to deal with primary dysmenorrhea were analgesic's consumption.